Succinylated polysaccharide-based thermosensitive polyelectrostatic complex for protein drug delivery

Jung, Young-Seok; Park, Wooram; Na, Kun

doi:10.1177/0883911513517781

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…It indicated that SPL complexes could maintain the bioactivity of encapsulated lysozyme in vitro while lysozyme was released from SPL complexes in a sustained manner in vivo . These results suggest the potential for long-term delivery of therapeutic proteins (Jung et al., 2014 ).…”

Section: Functionality Of Pullulan Nanogelsmentioning

confidence: 82%

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Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Zhang

Yang

et al. 2018

Drug Delivery

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Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and ‘switch-on/off’ mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine. A major section is used for biomedical applications of different nanogel systems based on modified pullulan, which exert smart stimuli-responses at ambient conditions such as charge, pH, temperature, light, and redox. Pullulan self-nanogels have found increasingly extensive application in protein delivery, tissue engineering, vaccine development, cancer therapy, and biological imaging. Functional groups are incorporated into self-nanogels and contribute to expressing desirable results such as targeting and modified release. Various molecules, especially insoluble or unstable drugs and encapsulated proteins, present improved solubility and bioavailability as well as reduced side effects when incorporated into self-nanogels. Finally, the advantages and disadvantages of pullulan self-nanogels will be analyzed accordingly, and the development of pullulan nanogel systems will be reviewed.

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Section: Functionality Of Pullulan Nanogelsmentioning

confidence: 82%

“…For this reason, Seo et al. applied l -lactide for polymerizing with pullulan, which resulted in a heat-related behavior (Seo et al., 2012 ; Jung et al., 2013 , 2014 ). The particle size of poly( l -lactide) (PLP) ( Table 3 ) nanogels with relatively higher lactide content enlarged rapidly over 32 °C.…”

Section: Functionality Of Pullulan Nanogelsmentioning

confidence: 99%

Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Zhang

Yang

et al. 2018

Drug Delivery

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“…The result showed that this formulation based on micellar nanocarriers could improve the effectiveness of piperacillin/tazobactam. Compared with the free drug form, piperacillin/tazobactam PLGA-PEG micelles are more effective against resistant Pseudomonas aeruginosa [ 73 , 74 , 75 ] Milani Morteza et al believed that PLGA-PEG micelles can be used as a good carrier to transport antibiotics into the bacterial biofilm and eliminate the formation of biofilm, probably being an attractive strategy to control the infection of drug-resistant Pseudomonas aeruginosa [ 73 ].…”

Section: Antimicrobial Nanomedicine Drug Delivery Systemsmentioning

confidence: 99%

“…In addition, due to biocompatibility and appropriate physiological characteristics, it has been used in many fields of biomedical engineering, including drug delivery and tissue engineering [ 104 , 105 , 106 ]. PLLA can react with other materials through esterification, and it is widely used in in vivo research and clinical application due to its biocompatibility and biodegradability [ 74 , 107 ]. Thus, Sobhan and coworkers prepared poly (L-lactide)-grafted-chondroitin sulfate (PLLA-g-CS) copolymers with different L-lactide contents by ring-opening polymerization [ 108 ].…”

Section: Antimicrobial Nanomedicine Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

et al. 2022

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Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

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“…The average diameters of the thermosensitive nanogels were 190 nm and 540 nm at 4 °C and 37 °C, respectively. In-vivo studies in nude mice indicated the sustained release of the drug [ 198 ].…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Ghaeini-Hesaroeiye

Bagtash

Boddohi

et al. 2020

Gels

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Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

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Succinylated polysaccharide-based thermosensitive polyelectrostatic complex for protein drug delivery

Cited by 7 publications

References 30 publications

Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

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