Successful Use of Valproate in Kleine-Levin Syndrome: A Case Report and Review of Cases Reported from India

Abstract

Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia and other symptoms and it is a really challenging for the physician, since its causes are not yet clear, and available treatment options are not having adequate support. Here, we are reporting a case with successful use of valproate in KLS and also reviewing the cases reported from India.

Sleeping Beauty Syndrome: A Case Report and Review of Female Cases Reported from India

“…[1] Similarly, on comparing index case with reported male cases from India, we found significantly longer duration of illness in index case (16 years) compared to 1-4 years in male cases. [12] Index case had onset of KLS at 26 years of age whereas reported male cases had onset from 7 to 24 years of age. [12] To conclude, KLS is a neurological disorder with a lot of psychiatric coloring, therefore, a case may present to a neurologist, physician, or psychiatrist depending on patients' awareness, feasibility, and predominant symptoms.…”

“…[12] Index case had onset of KLS at 26 years of age whereas reported male cases had onset from 7 to 24 years of age. [12] To conclude, KLS is a neurological disorder with a lot of psychiatric coloring, therefore, a case may present to a neurologist, physician, or psychiatrist depending on patients' awareness, feasibility, and predominant symptoms. Hence, it is important for clinicians to have high index of suspicion on such atypical presentations.…”

“…[ 1 ] Similarly, on comparing index case with reported male cases from India, we found significantly longer duration of illness in index case (16 years) compared to 1–4 years in male cases. [ 12 ] Index case had onset of KLS at 26 years of age whereas reported male cases had onset from 7 to 24 years of age. [ 12 ]…”

“…[ 12 ] Index case had onset of KLS at 26 years of age whereas reported male cases had onset from 7 to 24 years of age. [ 12 ]…”

Successful Long-term Management of a Child with Kleine-Levin Syndrome with Low-dose Lithium

“…One such case of an adolescent male with KLS did not respond to lithium despite the blood levels to be as high as 0.8 mEq/L, unlike our case. [ 7 ] The patient responded well to the treatment with valproate which was then continued for 5 years. Few other Indian cases also responded well to the treatment.…”