Sleeping Beauty Syndrome: A Case Report and Review of Female Cases Reported from India

Nebhinani, Naresh; Suthar, Navratan

doi:10.4103/0253-7176.207319

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…As often happens with rare clinical syndromes lacking a biological marker such as KLS, the early described diagnostic clinical characteristics tend to expand with time as additional cases are published. The recurrent attacks of hypersomnia, hyperphagia and hypersexuality, the classical Critchley "tirade " (Critchley & Hoffman, 1942), affecting previously healthy youngsters who "grow out of it", reminded authors as well as public of legendary "sleepers" such as Kumbhakarna, a giant who was made by the Gods to fall asleep for 6 months, and upon waking up he ate everything ("Ramayana": ancient Indian mythological epic, 8th-4th century BC), (Chilakamarri & Kryger, 2019), "The sleeping beauty" by the Grimm brothers (Nebhinani & Suthar, 2017), Honi HaMeagel , a-1st century BC Jewish scholar who fell asleep for 70 years (Klein, 1901) and Washington Irving's fictional Rip Van Winkle who fell asleep and woke up after 20 years (Lisk, 2009). By using the eponym "Kleine Levin" in publications of atypical cases, a "mysterious fragrance" was added and subsequently, a growing number of "atypical" cases were published i.e.…”

Section: Disscusionmentioning

confidence: 99%

Atypical Kleine Levin Syndrome: Atypical or “Something Else”

2024

J Psychol Neurosci

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Objective: To describe in some detail published cases who were diagnosed as atypical Kleine-Levin syndrome (KLS), and discuss the validity and usefulness of this diagnostic term. Methods: The English written literature was reviewed using the search terms Atypical KLS, KLS mimic, KLS like and KLS variant. Only reports which provided complete clinical features were reviewed. The present diagnostic criteria of KLS were applied in each case and the reasons why each case was considered as atypical were outlined in a table form. The cases were grouped according to the primary etiologies which could explain the symptoms into infectious, autoimmune, cerebrovascular, head trauma, brain tumor and genetic metabolic disorders. Cases in whom we could not establish a definite diagnosis were coined “atypical “and a few which could not be assigned to a specific group were coined “miscellaneous”. Results: Fifty seven reports describing 60 “atypical“ cases were found. Out of those, 14 suffered from a variety of medical conditions which could explain the symptomology while in 19 cases a definite diagnosis could not reached. Five cases were coined as “miscellaneous” since we could not assign them to a specific group. Conclusion: The eponym “atypical” KLS, refers to patients in whom a variety of medical disorders were associated with sleep-wake disorder, however, it seems appropriate that in such cases the diagnosis should express the primary cause of the symptoms rather than suggesting that those cases are a variant of KLS.

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Section: Disscusionmentioning

confidence: 99%

Atypical Kleine Levin Syndrome: Atypical or “Something Else”

2024

J Psychol Neurosci

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“…Most patients exhibit also apathy and derealisation [ 4 ]. Women appear to experience a longer disease course, lower frequency of hypersexuality, and higher frequency of depressed mood than men [ 3 , 11 ]. As discussed below, these features suggest that specific areas of the brain may be affected in KLS but do not suggest a specific pathological process.…”

Section: Introductionmentioning

confidence: 99%

Kleine-Levin syndrome: clues to aetiology

2018

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Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1–2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected. An autoimmune aetiology is consistent with the available data. In this review, we argue that, in order to further our understanding of KLS, there needs to be a co-ordinated international effort to standardise approaches to functional imaging studies, genetic analyses that specifically address the possibility of an autoimmune aetiology, and clinical trials of immunosuppressive therapies.

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Periodic hypersomnolence in a young female patient: a case report and literature review

Alemohammad

Jamshidi

Najafi

2022

Egypt J Neurol Psychiatry Neurosurg

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Background Kleine–Levin syndrome (KLS) is a disease with periodic hypersomnolence accompanied by abnormal behavior with a rare prevalence in female. Case presentation Here, we report a young lady with chief complaint of hypersomnolence for 6 years of visits and any history of sleep attack, sleep paralysis, and cataplexy. Polysomnography was performed for the patient. The respiratory disturbance index was normal. In MSLT the patient had two SOREMs with mean sleep latency of 7 min. She was diagnosed as Kleine–Levin syndrome as the sleepiness symptoms had a periodic pattern without other characteristics of central hypersomnolence disorders. The patient did not report behavioral characteristics of KLS reported in previous literature. She improved spontaneously after a while in follow-ups without any further treatment. Conclusions Although KLS is reported rarely in female gender and there are previous defined behavioral symptoms for this syndrome, periodic pattern of sleepiness should raise this diagnosis after exclusion of other hypersomnolence causes.

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Sleeping Beauty Syndrome: A Case Report and Review of Female Cases Reported from India

Cited by 3 publications

References 9 publications

Atypical Kleine Levin Syndrome: Atypical or “Something Else”

Atypical Kleine Levin Syndrome: Atypical or “Something Else”

Kleine-Levin syndrome: clues to aetiology

Periodic hypersomnolence in a young female patient: a case report and literature review

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