Successful Use of Samarium 153 for Emergency Treatment of Disseminated Intravascular Coagulation Due to Metastatic Hormone Refractory Prostate Cancer

Ruffion, A.; Manel, Anne‐Marie; Valignat, C.; Lopez, J.-G.; Perrin-Fayolle, Olivier; Perrin, Paul B.

doi:10.1097/00005392-200009010-00043

Cited by 11 publications

(8 citation statements)

References 2 publications

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“…Third-line hormone treatments with estrogens such as diethylstilbestrol or ketoconazole have been shown to be helpful in some cases [ 3 , 4 ]. Despite the report of a successful use of samarium 153 [ 5 ], radio-pharmaceutical treatments should be used with caution since a death related to the development of acute DIC following administration of strontium 89 has also been described [ 6 ]. Mitoxantrone chemotherapy has been reported to be effective, but the normalization of blood tests required at least 1 week [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Very Fast Recovery of Acute Disseminated Intravascular Coagulation with Abiraterone Acetate in a Patient with Bone Metastases from Castrate-Resistant Prostate Cancer

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Very Fast Recovery of Acute Disseminated Intravascular Coagulation with Abiraterone Acetate in a Patient with Bone Metastases from Castrate-Resistant Prostate Cancer

et al. 2014

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“…5 Clinical signs of DIC are noted in only 0.4%-1.65% of patients with prostate cancer, including a bleeding tendency. 6 In these patients, DIC can be triggered by surgical procedures like prostate biopsy causing hemorrhage in multiple sites, such as the skin, genitourinary organs, gastrointestinal tracts and submit your manuscript | www.dovepress.com…”

Section: Discussionmentioning

confidence: 99%

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Ohashi¹,

Hosokawa²,

Kimura³

et al. 2013

IJNRD

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Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder in patients with prostate cancer. However, renal involvement in DIC associated with prostate cancer has rarely been documented. Herein, we present a case of metastatic prostate cancer presenting with acute renal failure (RF) triggered by DIC. An 80 year old man with metastatic prostate cancer was treated with antihormone therapy at an outpatient clinic. He was admitted to our hospital because of severe dyspnea and progressive RF. A hemorrhagic tendency was not clinically evident. Laboratory tests exhibited a significant coagulation disorder, suggestive of DIC. Despite treatment, his RF and dyspnea worsened, and he eventually passed away. An autopsy study revealed hypertensive nephrosclerosis superimposed by fibrin rich thrombi formation involving glomerular capillaries and arterioles characteristic of DIC. Additionally, focal segmental glomerulosclerosis was identified, which was presumably secondary to the glomerular endothelial and/or podocyte injury augmented by DIC. Those findings showed that glomerular injury, which was induced and subsequently exacerbated by DIC associated with prostate cancer, highly contributed to the progression of RF in our case. A differential diagnosis of DIC should be considered when a patient with prostate cancer presents with renal dysfunction.

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“…A variety of hormonal maneuvers including DES [5,6] and ketoconazole [7,8] have been used with limited success. Several successful case reports with radioactive agents including samarium 153 have been reported with limited success [9].…”

Section: Discussionmentioning

confidence: 99%

Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report

Shirai

Chaudhary²

2007

The Scientific World JOURNAL

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Disseminated Intravascular Coagulopathy (DIC) is the most common coagulopathy in patients with prostate cancer. Though rare, it could be fatal without treatment. Literature suggests that there is significant activation of fibrinolytic pathway. Pathophysiology of DIC in patients with prostate cancer is not completely understood. We present here a case of chronic DIC in a patient with metastatic androgen independent prostate cancer. His DIC was managed successfully with a combination of aminocaproic acid and low weight molecular heparin. The use of low molecular weight heparin may make management of chronic DIC in prostate cancer more feasible in an out patient setting.

show abstract

Successful Use of Samarium 153 for Emergency Treatment of Disseminated Intravascular Coagulation Due to Metastatic Hormone Refractory Prostate Cancer

Cited by 11 publications

References 2 publications

Very Fast Recovery of Acute Disseminated Intravascular Coagulation with Abiraterone Acetate in a Patient with Bone Metastases from Castrate-Resistant Prostate Cancer

Very Fast Recovery of Acute Disseminated Intravascular Coagulation with Abiraterone Acetate in a Patient with Bone Metastases from Castrate-Resistant Prostate Cancer

Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer

Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report

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