Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies

Aqueous extracts of FBD, a Chinese herb formula composed ofPoria cocos, Atractylodes macrocephala,andAngelica sinensisreverse scopolamine induced memory deficit in ICR mice

“…Traditional Chinese medicine (TCM) has a long history of clinical application, and has become a vital complementary AD therapy (Iwasaki et al, 2005;Shinno et al, 2007;Lu, 2001;Toriizuka et al, 2000;Zhu & Hu, 2007;Howes & Houghton, 2003). Our present study further demonstrates the protective potential of the TCM formula FBD against scopolamine induced memory disruption in mice.…”

“…Recently, several traditional formulae comprising the three herbs have been successfully applied to treat AD, such as yi-gan-san (yokukan-san) (Iwasaki et al, 2005;Shinno et al, 2007), and danggui-shaoyao-san (toki-shakuyaku-san) (Lu, 2001;Toriizuka et al, 2000). Moreover, the three herbs were beneficial to cognitive function, whether used alone (Hsieh et al, 2000;Smriga et al, 1995;Oh et al, 2004;Hatip-Al-Khatib et al, 2004), or in combination (fu ling (F) -bai zhu (B) -dang gui (D), FBD) (Lin et al, 2005;Dong, et al, 2006).…”

Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

“…One good example of Ibyodochi is YKS, a single prescription that is reported to be effective in treating many different diseases such as dementia,1–14 sleep disorders,15,16 tardive dyskinesia,17 borderline personality disorder,18 and schizophrenia-related diseases 19,20. On the other hand, different herbal formulas may also be used to treat the same disease (called “Dobyoichi” in Kampo).…”

“…YKS has attracted attention in the field of psychiatry due to reports of its efficacy in patients with dementia 1–14. In addition, therapeutic effects of YKS have been reported in the treatment of sleep disorders,15,16 tardive dyskinesia,17 borderline personality disorder,18 and schizophrenia-related diseases 19,20.…”

Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

“…Yokukansan (YKS), a traditional Japanese medicine referred to as a "kampo medicine" in Japan, has been approved by the Ministry of Health, Labour, and Welfare of Japan as a remedy for neurosis, insomnia, and night crying in children. Recently, YKS has been reported to ameliorate such BPSD as hallucinations, agitation, and aggressiveness in patients with AD, dementia with Lewy bodies (DLB), and other forms of senile dementia (Iwasaki et al, 2005a,b;Mizukami et al, 2009;Shinno et al, 2007Shinno et al, , 2008. The usual adult dose for treatment of YKS is 7.5 g/day orally in 3 divided doses before or between meals.…”