Successful treatment with topical imiquimod of anal Buschke-Löwenstein tumor in a child

Zaouak, Anissa; Hammami-Ghorbel, Houda; Koubaa, Wafa; Midassi, O.; Benmously-Mlika, Rym; Debbiche, Achraf; Fenniche, Samy

doi:10.1111/dth.12261

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…This procedure must be performed in general anesthesia and requires management of painful sequelae, with a high risk of infection. Therefore, in the recent years, the treatment has been focused on topical therapy 7‐12 . Almost all topical drugs, as imiquimod, are currently not licensed in childhood.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, 17 infant cases successfully treated with imiquimod for CA are reported in the literature ([imiquimod + condyloma + infant] has been researched on PubMed) (Table 1). 5‐15 …”

Section: Resultsmentioning

confidence: 99%

“…Therefore, in the recent years, the treatment has been focused on topical therapy. [7][8][9][10][11][12] Almost all topical drugs, as imiquimod, are currently not licensed in childhood. However, imiquimod has been used in the last years in clinical practice for its efficacy and tolerability with mild and transient adverse reactions (itching, burning, and erythema), compared to other topical treatments.…”

Section: Resultsmentioning

confidence: 99%

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Successful topical treatment of anal giant condylomata acuminata in an infant

Giancristoforo

Diociaiuti

Tchidjou

et al. 2020

Dermatologic Therapy

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Anogenital condylomata acuminata are induced by human papillomavirus (HPV) and they rarely manifest in immunocompetent children. Therapeutic options depend on patient's age and general conditions and extension of the lesions. However, management is still a challenge and recurrences are frequent. Cryotherapy, laser, and surgical treatments in children are painful and frequently require general anesthesia. Imiquimod is a topical immune response modifier and constitutes a noninvasive alternative for the treatment of anogenital condylomata acuminata. Here, we report an infant admitted to our hospital with a giant vegetative papillomatous lesion on the perianal region surrounded by small satellites papules. PCR for HPV confirmed the clinical diagnosis of giant condylomata acuminata due to HPV type 6. The child has been successfully treated with topical 5% imiquimod cream without side effects. Although topical imiquimod is not licensed for pediatric age, this report highlights the potential benefits of its use in selected pediatric cases.

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Section: Resultsmentioning

confidence: 99%

“…In addition, 17 infant cases successfully treated with imiquimod for CA are reported in the literature ([imiquimod + condyloma + infant] has been researched on PubMed) (Table 1). 5‐15 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Successful topical treatment of anal giant condylomata acuminata in an infant

Giancristoforo

Diociaiuti

Tchidjou

et al. 2020

Dermatologic Therapy

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“…Treatment with a trichloroacetic acid solution of 80%-90% or podophyllotoxin solution of 0.5%, radiotherapy, chemotherapy, immunotherapy, or cryotherapy, has been suggested but also criticized [5][6][7][8][9][10]26]. A few studies also put forward imiquimod as an effective treatment option for BLT [27,28]. Although complete clearance of common warts has been observed in 45%-56% of the patients treated with the imiquimod, its efficacy in the treatment of BLT is questionable [29].…”

Section: Discussionmentioning

confidence: 99%

Radical surgical management of perianal giant condyloma acuminatum of Buschke and Löwenstein: long-term results of 11 cases

et al. 2023

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Perianal Buschke-Löwenstein tumor (BLT) is characterized by an exophytic cauliflower-like mass surrounding the perianal region. Its tendency to infiltrate the adjacent tissues, its massiveness, and its high recurrence rate cause difficulties in treatment. The aim of this study is to report our strategy with wide local excision and flap reconstruction for BLT. Methods: From November 2002 to June 2019, 11 patients (9 males) with a mean age of 33.45 years (range, 19-54 years) were operated on for BLT. All patients underwent wide local excision and V-Y flap reconstruction, supplemented with other flaps whenever needed. No additional modalities were used. Results: Two patients had a history of anal intercourse while all patients were human immunodeficiency virus-negative. The mean tumor length was 15.54 ± 1.34 cm (range, 10-26 cm). Human papillomavirus 6 was the most common type identified. Partial wound dehiscence developed in 3 patients, while anal stenosis, mucosal ectropion, or local recurrence was not observed during the mean follow-up period of 50.45 ± 1.75 months (range, 10-196 months). Conclusion: In patients with perianal BLT, wide local excision and flap reconstruction result in a high healing rate without significant complications.

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“…Other options include cryosurgery, topical chemotherapy (mostly based on cisplatin, 5-fluorouracil and imiquimod), electrocautery, and photodynamic therapy 3,5,15 . Radiation therapy for VC is controversial 2,8 .…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Verrucous Carcinoma: Revisiting the Definition

et al. 2018

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Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin.Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Histopathologically, epithelial tumor cells grew pushing the stroma, while the basement membrane was intact. No prominent cellular atypia or hyperchromatin was found. Case 2, a male patient, aged 53 years, had a verrucous plaque at the border between his scrotum and inner aspect of his thigh. A pathological diagnosis of VC was made using an excisional specimen. Making a definitive diagnosis of VC is challenging but crucial. Pathological diagnosis using a small specimen might cause underdiagnosis or overdiagnosis. To avoid this, pertinent pathological diagnosis using an ample specimen is required. We also revisited the definition of VC to precisely understand its nature. (J Nippon Med Sch 2018; 85: 47 50)

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Successful treatment with topical imiquimod of anal Buschke-Löwenstein tumor in a child

Cited by 7 publications

References 14 publications

Successful topical treatment of anal giant condylomata acuminata in an infant

Successful topical treatment of anal giant condylomata acuminata in an infant

Radical surgical management of perianal giant condyloma acuminatum of Buschke and Löwenstein: long-term results of 11 cases

Two Cases of Verrucous Carcinoma: Revisiting the Definition

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