Two Cases of Verrucous Carcinoma: Revisiting the Definition

Abstract

Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin.Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Histopathologically, epithelial tumor cells grew pushing the stroma, while the basement membrane was intact. No prominent cellular atypia or hyperchromatin was found. Case 2, a male patient, aged 53 years, had a verrucous plaque at the border between his scrotum and inner aspect of his thigh. A pathological diagnosis of VC was made using an excisional specimen. Making a definitive diagnosis of VC is challenging but crucial. Pathological diagnosis using a small specimen might cause underdiagnosis or overdiagnosis. To avoid this, pertinent pathological diagnosis using an ample specimen is required. We also revisited the definition of VC to precisely understand its nature. (J Nippon Med Sch 2018; 85: 47 50)

Cutaneous Verrucous Carcinomas: A Review

“…We reviewed 26 publications with a total of 115 patients with CVC and found that 19 patients recurred with a prevalence of 16.5% and a mean age of 59.6 years (range 38-91), 16 of whom (16/19,84.2%) within 2 years (2, 24 months) after surgery, however, one patient recurred at 26 months after surgery, and two patients were not available. 4 -6,11,12,15,27,30,35,36,42,47,49,62,68,73,74,77,84 -91 Of the recorded data on recurrence, there were 10 cases in men (10/16, 62.5%) and 6 cases in women (6/16, 37.5%). The majority (10/19 patients) of the recurrent cases were located on the foot, one each on the lower leg, axilla, ankle, and hand, in addition to five cases not documented.…”