Successful treatment of task‐specific lower extremity dystonia by ventro‐oral thalamotomy

Horisawa, Shiro; Kohara, Kotaro; Kawamata, Takakazu; Taira, Takaomi

doi:10.1002/mds.27180

Cited by 5 publications

(10 citation statements)

References 5 publications

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“…11,12 We have already reported several studies describing the efficacy of Vo-thalamotomy using radiofrequency and gamma knife. [16][17][18][19][20] In this study, the WCRS, TMDS, and ADDS scores significantly improved at 12 months compared to those at baseline. In our previous study investigating the results of radiofrequency Vo-thalamotomy in 171 patients, the task-specific FHD scores (1-5, with lower scores indicating greater severity), a scale that is almost the same as TMDS, before surgery and at the last available follow-up (mean 47.36 months) were 1.72 AE 0.57 and 4.39 AE 1.07, respectively, which are similar to the results of the present study.…”

Section: Discussionmentioning

confidence: 48%

Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study

Horisawa

Yamaguchi²,

Abe

et al. 2021

Movement Disorders

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Background: The efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for the treatment of focal hand dystonia (FHD) is not well known. Objective: We aimed to prospectively investigate the efficacy of MRgFUS thalamotomy for the treatment of FHD. Methods: We performed MRgFUS thalamotomy of the ventro-oral (Vo) nucleus in 10 patients with FHD. We evaluated the scores of the Writer's Cramp Rating Scale (WCRS, 0-30; higher scores indicating greater severity), Tubiana Musician's Dystonia Scale (TMDS, 0-5; lower scores indicating greater severity), and Arm Dystonia Disability Scale (ADDS, 0%-100%; lower scores indicating greater disability) at baseline and 3 and 12 months post-treatment.Results: WCRS, TMDS, and ADDS scores significantly improved from 6.3 AE 2.7, 1.4 AE 0.5, and 58.7% AE 14.3% at baseline to 1.6 AE 3.1 (P = 0.011), 5.0 AE 0 (P = 0.0001), and 81.6% AE 22.9% (P = 0.0229) at 12 months, respectively. There was one prolonged case of dysarthria at 12 months. Conclusion:We show that MRgFUS Vo-thalamotomy significantly improved FHD.

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Section: Discussionmentioning

confidence: 48%

Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study

Horisawa

Yamaguchi²,

Abe

et al. 2021

Movement Disorders

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“…While examining clinical findings and reviewing the papers and video clips, the authors of case series were contacted by email for clarification of patients' clinical findings and history. After contacting several authors (5, 12), we confirmed that one case was duplicated (5, 7) and another case included a patient who experienced FTSD while not only walking downstairs but also when running and cycling (12). We found three cases in Korea of FTSD in the lower limb only when walking stairs and two cases in Japan.…”

Section: Methodsmentioning

confidence: 66%

“…For this reason, additional similar cases are needed to clarify whether the FTSD associated with stairs has a mechanism like that of PKD. Taira et al were the first to report the long-term effects of ventro-oral (Vo) thalamotomy on FTSD, especially in foot dystonia (12). The patient's dystonia during running, cycling, or walking downstairs was improved dramatically after surgery, indicating that Vo thalamotomy can be a helpful treatment in patients with FTSD associated with stairs.…”

Section: Discussionmentioning

confidence: 99%

Focal Task-Specific Lower Limb Dystonia Only When Walking Stairs: Is It a New Disease Entity?

Baik

Lee

et al. 2019

Front. Neurol.

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Introduction: Focal task-specific dystonia in the lower limb or foot often occurs only during walking, running, hiking, or cycling. Several medications and botulinum toxin injection are effective in patients with this disorder. The objective of this study was to understand the spectrum of focal task-specific dystonia in the lower limb only when walking stairs and to compare other types of task-specific dystonia.Methods: All original articles and case reports were collected and reviewed using PubMed. In addition, all video clips of published cases were evaluated, and patients' clinical findings analyzed. The present study included 12 patients described in previous studies and five new Asian patients found in the medical records.Results: Most of the patients were women, and the onset age was 42 years. Ten patients were classified as the Kicking type, including three patients with the rKicking type, and six patients were considered as the Lifting type; however, only one patient was not included in any of the types. Symptoms in most of the patients did not improve with any medications or botulinum toxin injection. The symptoms of most patients did not change over a long time.Conclusion: Most patients showed the dystonic symptom when walking downstairs rather than upstairs. Psychogenic dystonia is a disease differentially diagnosed with this dystonia. Unlike other types of focal task-specific dystonia, the response to treatment was disappointing because most of the medications and botulinum toxin injection were not effective. The prognosis is completely different from that of other types of focal task-specific dystonia.

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“…We selected the thalamus as a treatment target for focal foot dystonia according to our previous successful experience. 8 In cases where tremor and/or dystonia interfere with the patients' daily lives, stereotactic neurosurgery, including thalamotomy and DBS, can be a feasible treatment option.…”

Section: Discussionmentioning

confidence: 99%

“…While there has been only one reported case of PSP with resting tremor successfully treated by thalamotomy, 7 surgical treatment for focal foot dystonia in cases of PSP has not been reported. We selected the thalamus as a treatment target for focal foot dystonia according to our previous successful experience 8 . In cases where tremor and/or dystonia interfere with the patients’ daily lives, stereotactic neurosurgery, including thalamotomy and DBS, can be a feasible treatment option.…”

Section: Discussionmentioning

confidence: 99%

Thalamotomy for tremor and dystonia in progressive supranuclear palsy

Machida

Horisawa

Yokoi

et al. 2022

Neurology & Clinical Neurosc

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Thalamotomy for tremor and dystonia in patients with progressive supranuclear palsy (PSP) has been rarely reported. A 71-year-old woman was diagnosed with PSP. Resting tremor in the left hand and dystonic posture in the left foot were present, both of which were dramatically improved after radiofrequency thalamotomy. The limb motor function and gait on the PSP rating scale showed 63.6% and 14.3% improvement, respectively. The results of this study suggest that thalamotomy can be an alternative treatment option for tremor and dystonia in PSP.

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Successful treatment of task‐specific lower extremity dystonia by ventro‐oral thalamotomy

Cited by 5 publications

References 5 publications

Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study

Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study

Focal Task-Specific Lower Limb Dystonia Only When Walking Stairs: Is It a New Disease Entity?

Thalamotomy for tremor and dystonia in progressive supranuclear palsy

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