Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy

Diernaes, Jon Erik Fraes; Bygum, Anette

doi:10.1016/j.pdpdt.2013.08.003

Cited by 10 publications

(3 citation statements)

References 5 publications

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“…These treatments, however, are invariably not based on controlled clinical studies. Recently, it was reported that a case of PFB was successfully treated with photodynamic treatment .…”

Section: Management Of Pfbmentioning

confidence: 99%

Pseudofolliculitis barbae: understanding the condition and the role of facial grooming

Gray¹,

McMichael

2016

Intern J of Cosmetic Sci

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Pseudofolliculitis barbae (PFB) is an inflammatory condition of the beard area, with a high prevalence in men of subequatorial African ancestry and, to a much lesser extent, Indo-Europeans. But it can affect both men and women of all ethnicities. Invariably reported as being associated with shaving, recent evidence suggests a strong genetic component in patients with persistent PFB. There is a lack of robust clinical evidence to support recommendations to avoid or curtail shaving or to shave with a single-blade razor. There is recent clinical evidence that PFB is not exacerbated by daily shaving with a multiblade razor as part of a regimen. Further, there is preliminary evidence that a daily shaving regimen, which includes pre-shave hydration and post-shave moisturization, may be beneficial. To develop evidence-based initial management strategies for PFB, there is a requirement for more randomized blinded clinical trials comparing the use of multi- and single-edge razors, different shaving techniques, shaving frequencies and pre- and post-shaving cosmetic products.

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“…These treatments, however, are invariably not based on controlled clinical studies. Recently, it was reported that a case of PFB was successfully treated with photodynamic treatment .…”

Section: Management Of Pfbmentioning

confidence: 99%

Pseudofolliculitis barbae: understanding the condition and the role of facial grooming

Gray¹,

McMichael

2016

Intern J of Cosmetic Sci

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“…Dosages should be conservative to avoid induction of dyspigmentation in the darkest patients [ 13 -16 ]. Photodynamic therapy has also been described for lesion reduction [ 17 ]. Efl ornithine can be used to reduce hair size and enhance results from laser [ 18 ].…”

Section: Therapymentioning

confidence: 99%

Pseudofolliculitis Barbae

Silverberg¹

2015

Pediatric Skin of Color

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Pseudofolliculitis barbae is a chronic infl ammatory folliculitis of the beard area that occurs after onset of puberty. Lesions are most common in males, but can occur in females with terminal hair growth on the chin area, the latter warranting hormonal evaluation for signs of androgen excess. Onset of pseudofolliculitis barbae begins after initiation of hair removal in the chin and beard area by shaving and/or plucking. Lesions are a result of ingrowth of the hairs causing infl ammatory lesions such as papules and pustules and eventually fi brosis, scarring alopecia, and sometimes keloidal type scars. Therapy can include avoidance of shaving, usage of specialized shaving equipment that prevents an aggressively close shave, and application of acne therapies as well as anti-infl ammatory agents. In medically resistant cases, long-pulsed hair removal lasers, e.g., Nd:Yag, have been described as adjunctive therapies for clearance of lesions. Keywords Pseudofolliculitis barbae • Razor bumps • Keloids

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“…Adverse effects of shaving, such as skin irritation, inflammation, and parakeratosis [2,[12][13][14] as well as epidermal thickening, impaired epidermal barrier integrity [15][16][17], and occasionally pseudofolliculitis barbae [18,19] and hyperpigmented papules [20] are thought to be mediated by factors such as the release of pro-inflammatory cytokines from epidermal keratinocytes, sensory nerve fibre activation, and vasodilation [13,21]. Epilation techniques can have similar short-term adverse effects and frequently cause post-epilation pain, but how they interfere with pilosebaceous physiology remains essentially unknown.…”

Section: Introductionmentioning

confidence: 99%

Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach

Bertolini,

Gherardini,

Chéret

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveElectrical epilation of unwanted hair is a widely used hair removal method, but it is largely unknown how this affects the biology of human hair follicles (HF) and perifollicular skin. Here, we have begun to explore how mechanical epilation changes selected key biological read‐out parameters ex vivo within and around the pilosebaceous unit.MethodsHuman full‐thickness scalp skin samples were epilated ex vivo using an electro‐mechanical device, organ‐cultured for up to 6 days in serum‐free, supplemented medium, and assessed at different time points by quantitative (immuno‐)histomorphometry for selected relevant read‐out parameters in epilated and sham‐epilated control samples.ResultsEpilation removed most of the hair shafts, often together with fragments of the outer and inner root sheath and hair matrix. This was associated with persistent focal thinning of the HF basal membrane, decreased melanin content of the residual HF epithelium, and increased HF keratinocyte apoptosis, including in the bulge, yet without affecting the number of cytokeratin 15+ HF epithelial stem cells. Sebocyte apoptosis in the peripheral zone was increased, albeit without visibly altering sebum production. Epilation transiently perturbed HF immune privilege, and increased the expression of ICAM‐1 in the bulge and bulb mesenchyme, and the number of perifollicular MHC class II+ cells as well as mast cells around the distal epithelium and promoted mast cell degranulation around the suprabulbar and bulbar area. Moreover, compared to controls, several key players of neurogenic skin inflammation, itch, and/or thermosensation (TRPV1, TRPA1, NGF, and NKR1) were differentially expressed in post‐epilation skin.ConclusionThese data generated in denervated, organ‐cultured human scalp skin demonstrate that epilation‐induced mechanical HF trauma elicits surprisingly complex biological responses. These may contribute to the delayed re‐growth of thinner and lighter hair shafts post‐epilation and temporary post‐epilation discomfort. Our findings also provide pointers regarding the development of topically applicable agents that minimize undesirable sequelae of epilation.

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Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy

Cited by 10 publications

References 5 publications

Pseudofolliculitis barbae: understanding the condition and the role of facial grooming

Pseudofolliculitis barbae: understanding the condition and the role of facial grooming

Pseudofolliculitis Barbae

Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach

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