Successful treatment of profound hypothermia of the newborn

Konopova, Patricia; Janota, Jan; Termerova, Jana; Burianová, Iva; Paulová, Magdalena; Zach, Jiří

doi:10.1111/j.1651-2227.2008.01052.x

Cited by 6 publications

(7 citation statements)

References 12 publications

(20 reference statements)

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“…Konopova et al30 successfully treated a profoundly hypothermic term newborn whose rectal temperature was 25°C, using the gradual rewarming approach. Slow rewarming was considered to be a protective factor against both rapid cardiovascular changes and negative impact on cerebral flow 30. Results from animal experiments demonstrated that fast rewarming caused an abrupt increase in cardiac output and a sharp drop in systemic vascular resistance 31.…”

Section: Discussionmentioning

confidence: 99%

“…Although the outcomes of hypothermic neonates are correlated with the severity of hypothermia, this raises an important question: which is the better approach for rewarming neonates with hypothermia whose temperature is less than 28°C, rapid or slow rewarming? Some authors pointed out the negative impact of fast rewarming on circulation 30,31. Konopova et al30 successfully treated a profoundly hypothermic term newborn whose rectal temperature was 25°C, using the gradual rewarming approach.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors pointed out the negative impact of fast rewarming on circulation 30,31. Konopova et al30 successfully treated a profoundly hypothermic term newborn whose rectal temperature was 25°C, using the gradual rewarming approach. Slow rewarming was considered to be a protective factor against both rapid cardiovascular changes and negative impact on cerebral flow 30.…”

Section: Discussionmentioning

confidence: 99%

“…Slow rewarming was considered to be a protective factor against both rapid cardiovascular changes and negative impact on cerebral flow. 30 Results from animal experiments demonstrated that fast rewarming caused an abrupt increase in cardiac output and a sharp drop in systemic vascular resistance. 31 Furthermore, rapid rewarming may result in a more severe situation-more specifically, rewarming shock, which is precipitated by vasodilatation and lowered peripheral vascular resistance, which could cause significant hypotension.…”

Section: E124mentioning

confidence: 99%

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Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Tao

Chen

et al. 2022

Advances in Neonatal Care

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Background: Neonatal hypothermia is common around the world; however, profound hypothermia is a very rare-but life-threatening-event. Clinical Findings: This was a very rare case involving a 15-day old preterm infant diagnosed with profound hypothermia (rectal temperature, 27°C) concomitant with severe coagulation dysfunction and leukopenia on admission. Primary Diagnosis: Profound hypothermia together with severe coagulopathy, leukopenia, late-onset sepsis, and pneumonia. Interventions:The patient was rewarmed slowly, with a rectal temperature rising at a rate of 0.5°C/h < R < 1°C/h. Vital signs were closely monitored. Coagulation factors were supplemented by intravenous infusion of fresh frozen plasma. Supportive treatment with intravenous infusion of immunoglobulin was provided, and antibiotics were used empirically. Nil per os and intravenous rehydration were also implemented. Outcomes: The condition of the preterm infant gradually improved and was successfully discharged. Practice Recommendations: Profound hypothermia is very rare in preterm infants. However, once it occurs, it may be concomitant with severe coagulopathy and leukopenia. Successful management involves slow rewarming, prompt supplementation of coagulation factors, empirical antibiotics, and supportive treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: E124mentioning

confidence: 99%

See 2 more Smart Citations

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Tao

Chen

et al. 2022

Advances in Neonatal Care

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“…However, for extremely hypothermic neonates with temperatures below 33°C, caution was taken to ensure that rate of re-warming did not go faster than 2°C/hr to avoid the ugly consequences of "thermal-shock" that could follow rapid neonatal temperature changes [1,9].…”

Section: Neonate Was Then Transferred and Allowed For Up To 15mentioning

confidence: 99%

Validation of a Novel Technique that Minimises Early Neonatal Deaths - a Comparative Study

et al. 2017

JPNC

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Nigeria did not achieve the millennium development goal (MDG) for the reduction of under-5 mortality (U5M) in 2015. Neonatal death still accounts for nearly 50% of U5M, hence responsible for this failure. The World Health Organisation records showed that 79% of deceased neonates would die within the first-seven-days (F7D) of life in Nigeria. Prolonged postnatal delay before attainment of normal body temperature could be partly responsible. Reducing F7D deaths could improve Nigeria's overall record; hence the urgent need to device a technique that could be applied to achieve this. We developed a neonatal temperature control protocol "the initial-setpoint-algorithm (ISA)" as a response to temperature-related high F7D mortality rate. A total 134 cases (105 controls and 29 tests) were recruited. The cases drew from extremely-low birth weight and preterm neonates (BW = 600-1200 g, GA = 26-32 weeks) presenting at the University of Abuja Teaching Hospital Nigeria. Mortality outcomes were compared to investigate how the ISA group performed relative to the Control group. Applying ISA, Test-patients attained normotherm in 0.47 hr post-presenting (95%CI: 0.2); Control took 12.4 hrs (95%CI: 2.3). The F7D-deaths contribution to mortality in the control group was 71% (41 out of 58). There was no F7D death amongst the only two deceased neonates in the test group. The ISA helped quick attainment of normotherm in the Test-group; hence removed the immediate postnatal long exposure to damaging thermal shock that trailed other neonates to death within the F7D period.

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Association of Rewarming Rate on Neonatal Outcomes in Extremely Low Birth Weight Infants with Hypothermia

Morassutti

Cavallin²,

Zaramella

et al. 2015

The Journal of Pediatrics

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Successful treatment of profound hypothermia of the newborn

Cited by 6 publications

References 12 publications

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Validation of a Novel Technique that Minimises Early Neonatal Deaths - a Comparative Study

Association of Rewarming Rate on Neonatal Outcomes in Extremely Low Birth Weight Infants with Hypothermia

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