Successful treatment of pigmented purpuric dermatosis with griseoiulvin

Tamaki, Kunihiko; Yasaka, Nami; Osada, Atsushi; Shibagaki, Naotaka; Furue, Masutaka

doi:10.1111/j.1365-2133.1995.tb08650.x

Cited by 40 publications

(25 citation statements)

References 3 publications

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“…Treatment of PPDs is usually difficult. Various therapeutic options such as oral pentoxifylline, 11 topical steroids, 12 oral rutoside in combination with ascorbic acid, 13 griseofulvin 14 and cyclosporine 15 have been reported to have some efficacy in different forms of PPDs.…”

Section: Discussionmentioning

confidence: 99%

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

Fathy¹,

Abdelgaber

2011

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

Fathy¹,

Abdelgaber

2011

Acad Dermatol Venereol

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“…New lesions stopped appearing within a mean of 33 days 25 . It is likely that the immunomodulatory action of griseofulvin plays a role in this condition 3,25 …”

Section: Treatmentmentioning

confidence: 98%

“…In an open trial in six patients, a dose of griseofulvin 500 mg to 750 mg daily showed a response within a week 25 . New lesions stopped appearing within a mean of 33 days 25 .…”

Section: Treatmentmentioning

confidence: 99%

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Pigmented purpuric dermatoses: An overview

2004

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Pigmented purpuric dermatoses are a spectrum of disorders characterized by a distinct purpuric rash, mainly localized to the lower limbs, which are morphologically dissimilar but histopathologically indistinguishable. Their etiology remains obscure. They are rather resistant to treatment. Although diagnosed quite straightforwardly, the disease entity remains an enigma and a therapeutic challenge. The current narration discusses the outline of the epidemiology, etiopathogenesis, clinical features, histopathology and management of these disorders. The current review, hopefully, may once again rekindle interest in the entity, for it has been sparingly reported or discussed for the benefit of under- and/or postgraduates and those in practice, including family physicians.

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“…Clonal rearrangements of T cell receptors (TCR) have been detected in lesions of PPD [2]. Treatments with topical or systemic steroids [3, 4], griseofulvin [5], PUVA [6]and pentoxifylline [7, 8]have been described to be effective. We report a case of lichenoid pigmented purpuric dermatitis of Gougerot-Blum with clonal rearrangements of the γ-chain of the TCR responding to topical steroids.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal Rearrangement of the T Cell Receptor Gamma-Chain in Lichenoid Pigmented Purpuric Dermatitis of Gougerot-Blum Responding to Topical Corticosteroid Therapy

Lor

Krueger²,

Kempf³

et al. 2002

Dermatology

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Lichenoid pigmented purpuric dermatitis of Gougerot-Blum belongs to a group of closely related disorders which are termed pigmented purpuric dermatoses. It clinically manifests itself with grouped lichenoid papules in association with purpuric lesions. We report a case of lichenoid pigmented purpuric dermatitis of Gougerot-Blum with a heavy band-like CD4-positive lymphocytic infiltrate and clonal rearrangements of the γ-chain of the T cell receptors as detected by polymerase chain reaction/denaturing gradient gel electrophoresis. Monoclonal expansion of T cells in combination with certain histological features of mycosis fungoides (MF) might support a biological relationship between lichenoid pigmented purpuric dermatitis of Gougerot-Blum and MF. However, prompt clinical response to topical steroid therapy supports the benign clinical nature of our case.

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Successful treatment of pigmented purpuric dermatosis with griseoiulvin

Cited by 40 publications

References 3 publications

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

Treatment of pigmented purpuric dermatoses with Narrow‐band UVB: a report of six cases

Pigmented purpuric dermatoses: An overview

Monoclonal Rearrangement of the T Cell Receptor Gamma-Chain in Lichenoid Pigmented Purpuric Dermatitis of Gougerot-Blum Responding to Topical Corticosteroid Therapy

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