Successful treatment of mucous membrane pemphigoid with bortezomib

Saeed, Lina; Schmidt, Timothy H.; Gensler, Lianne S.; Gross, Andrew J.; Fox, Lindy P.; Scharschmidt, Tiffany C.; Gaensler, Karin; Naik, Haley B.; Rosenblum, Michael; Shinkai, Kanade

doi:10.1016/j.jdcr.2017.08.005

Cited by 12 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Bortezomib has been used for recalcitrant cases. 5 These therapies carry significant adverse effects and costs. Cyclophosphamide has gastrointestinal effects, causes cytopenia requiring close monitoring, and has a long-term cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of recalcitrant mucous membrane pemphigoid with multisystem involvement with baricitinib and methotrexate

Burningham¹,

Cao²,

Domínguez³

2022

JAAD Case Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Successful treatment of recalcitrant mucous membrane pemphigoid with multisystem involvement with baricitinib and methotrexate

Burningham¹,

Cao²,

Domínguez³

2022

JAAD Case Reports

View full text Add to dashboard Cite

“…Approximately 1.77 billion people globally, use pit latrines as a main source of sanitation (Graham and Polizzotto, 2013) and there is growing concern that the release of unsanitary chemicals and microbial contaminants from these pit latrines affects human health and can contaminate ground water (Graham and Polizzotto, 2013). Similarly, conventional flush latrines, if not flushed quickly enough, will emit odours and aerosols into the bathroom environment, in particular if there is no proper ventilation in the bathroom or toilet structure themselves (Saeed et al, 2018;Abney et al, 2021). These odours and pathogen-carrying aerosols can then enter other parts of a building through open doors (Nakagiri et al, 2015;Abney et al, 2021).…”

Section: Malodours and The Effects From Regular Flush And Septic Tank...mentioning

confidence: 99%

Staff perceptions of the effects of malodours from toilets at two schools in Gauteng Province, South Africa

Evans

Gilfillan

Odgers³

2022

JoGEA

View full text Add to dashboard Cite

In any school system, sanitary facilities can have a major effect on the productivity of staff and students, thus safe, adequate sanitation is essential to the academic programme. This study is part of a pilot project to determine the perceptions staff have of the effects of malodours from toilets on productivity and morale, at two schools. One school (School A) is located on the periphery of an urban area and had a septic tank system with inadequate toilet maintenance. The other school (School B) was in a well-established urban area with a flush latrine system, connected to municipal sewage pipes. Through a self-administered questionnaire we determined that School A had a very poor sanitation system that produced unbearable malodours that affected health, productivity and morale at the school, whereas School B had a healthy, well-maintained sanitation system that produced little odour. The malodour at School A had a negative effect on pupil attendance and staff morale at the school. The significant finding of the research was that all staff who participated indicated that malodours from either a flush latrine or a septic tank system could affect productivity of staff and students in the school environment.

show abstract

“…It might represent a powerful tool to specifically eliminate long-lived PCs, which to some extent resemble myeloma cells concerning their metabolism [235]. Positive effects have been postulated in numerous autoimmune diseases such as experimental myasthenia gravis [236], SLE [237] and primary Sjögren's syndrome [238], a case report describes the successful use in mucous membrane pemphigoid [239]. Another interesting approach is the attempt to selectively inhibit the so called "immunoproteasome", the first in-class molecule KZR-616 is under clinical investigation for therapy of dermatomyositis (NCT04033926) and has already been used to treat SLE patients in early clinical trials [167].…”

Section: Proteasome Inhibitors/immunoproteasome Inhibitorsmentioning

confidence: 99%

Skin-Associated B Cells in the Pathogenesis of Cutaneous Autoimmune Diseases—Implications for Therapeutic Approaches

Fetter

Niebel

Braegelmann

et al. 2020

Cells

View full text Add to dashboard Cite

B lymphocytes are crucial mediators of systemic immune responses and are known to be substantial in the pathogenesis of autoimmune diseases with cutaneous manifestations. Amongst them are lupus erythematosus, dermatomyositis, systemic sclerosis and psoriasis, and particularly those driven by autoantibodies such as pemphigus and pemphigoid. However, the concept of autoreactive skin-associated B cells, which may reside in the skin and locally contribute to chronic inflammation, is gradually evolving. These cells are believed to differ from B cells of primary and secondary lymphoid organs and may provide additional features besides autoantibody production, including cytokine expression and crosstalk to autoreactive T cells in an antigen-presenting manner. In chronically inflamed skin, B cells may appear in tertiary lymphoid structures. Those abnormal lymph node-like structures comprise a network of immune and stromal cells possibly enriched by vascular structures and thus constitute an ideal niche for local autoimmune responses. In this review, we describe current considerations of different B cell subsets and their assumed role in skin autoimmunity. Moreover, we discuss traditional and B cell-associated approaches for the treatment of autoimmune skin diseases, including drugs targeting B cells (e.g., CD19- and CD20-antibodies), plasma cells (e.g., proteasome inhibitors, CXCR4 antagonists), activated pathways (such as BTK- and PI3K-inhibitors) and associated activator molecules (BLyS, APRIL).

show abstract

Successful treatment of mucous membrane pemphigoid with bortezomib

Cited by 12 publications

References 10 publications

Successful treatment of recalcitrant mucous membrane pemphigoid with multisystem involvement with baricitinib and methotrexate

Successful treatment of recalcitrant mucous membrane pemphigoid with multisystem involvement with baricitinib and methotrexate

Staff perceptions of the effects of malodours from toilets at two schools in Gauteng Province, South Africa

Skin-Associated B Cells in the Pathogenesis of Cutaneous Autoimmune Diseases—Implications for Therapeutic Approaches

Contact Info

Product

Resources

About