Successful Treatment of Idiopathic Febrile Panniculitis (Weber-Christian Disease) with Thalidomide in a Patient Having Failed Multiple Other Medical Therapies

Barthel, H. Richard; Charrier, Ulrich; Kramer, Martin; Loch, Christoph H.

doi:10.1097/00124743-200210000-00005

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Two patients successfully treated with thalidomide have been reported, although the question of a possible spontaneous remission remains unanswered [6,7].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis

et al. 2009

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Weber-Christian Disease (WCD), also known as relapsing febrile lobular non-suppurative panniculitis, is a rare condition characterized by recurrent subcutaneous inflammatory nodules in the adipose tissue in addition to fever, malaise and other systemic manifestations such as polyarthralgia and polymyalgia. The association with small vessel vasculitis has been rarely reported. We report here an unusual case of WCD associated with small vessels vasculitis also describing the efficacy of Cyclosporin A treatment.

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“…Two patients successfully treated with thalidomide have been reported, although the question of a possible spontaneous remission remains unanswered [6,7].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis

et al. 2009

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“…Occasionally, it responds to glucocorticosteroids, but some patients may develop severe systemic forms, which can be fatal. 11 Methotrexate, 12 azathioprine, 13,14 antimalarials, 15 thalidomide, 16 cyclophosphamide, 17 polychemotherapy, 4,18 and cyclosporine 19 have been reported in the management of isolated cases with resistant forms.…”

mentioning

confidence: 99%

Long-Term Evolution of Cytophagic Histiocytic Panniculitis

et al. 2010

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“…Существуют единичные работы, свидетельствующие об эффективности блокаторов фактора некроза опухоли α [21,22]. Эффекта от применения антибактериальной терапии в лечении панникулита Крисчена-Вебера нет [24,25].…”

Section: Introductionunclassified

Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

Торгашова

Барабанова

Порханов

et al. 2019

Neuromuscular Diseases

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Christian–Weber disease refers to the group of panniculitis, which present an inflammation of the subcutaneous adipose tissue with the involvement of neutrophils, white blood cells and histiocytics, which leads to fibrosis in adipose tissue and sometimes to granulomatous changes. Clinically this pathology manifests from the formation of nodes in the subcutaneous adipose tissue, which appear suddenly, sporadically in some areas or multiple, sometimes forming large aggregations (plaques) or strands, shaped like a rosary. Consistency of nodes initially soft, then compacted, can form adhesions with the skin, the skin over them is not changed initially, followed by a color change from bright pink to brown-purple. Ends the process of atrophy of the affected area, sometimes with a depression in the center. Localization sites in the body are different; they are placed often on the buttocks, arms and legs. The duration of the process of the skin varies from a few days to a few months, after involution of old nodes may appear new ones, it are the cause of increasing the duration of the disease, having a relapsing course. It can be rather difficult to do differential diagnosis, which requires a great deal of experience of experts and a team approach to the study and treatment of this pathology. To confirm the diagnosis requires a biopsy of the skin. Prognosis depends on the nature of the disease and timely diagnosis.

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Successful Treatment of Idiopathic Febrile Panniculitis (Weber-Christian Disease) with Thalidomide in a Patient Having Failed Multiple Other Medical Therapies

Cited by 6 publications

References 31 publications

Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis

Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis

Long-Term Evolution of Cytophagic Histiocytic Panniculitis

Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

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