Successful treatment of glomus jugulare tumours with gamma knife radiosurgery: clinical and physical aspects of management and review of the literature

Martin, A. Navarro; Maitz, Ann; Grills, I.S.; Bojrab, Dennis I.; Kartush, Jack M.; Chen, Peter Y.; Hahn, Joav; Pieper, Daniel R.

doi:10.1007/s12094-010-0467-y

Cited by 45 publications

(17 citation statements)

References 36 publications

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“…Gamma Knife radiosurgery seems to offer better results in terms of tumor control and toxicity, however, the treatment of these tumors has to be tailored on the patients' age and symptoms, tumor volume, and extension. 3,6,9,20,24,31,35,48,52,53 20,24,26,35,50,51 Based on these findings, Gamma Knife radiosurgery can be considered as a primary treatment in almost all cases of glomus tumor, except for those patients experiencing symptoms and signs of intracranial hypertension, or for those patients presenting with huge tumors with caudal extension, that cannot be easily approached only with a Gamma Knife radiosurgery treatment.…”

Section: Discussionmentioning

confidence: 99%

Gamma Knife radiosurgery for glomus tumors: Long‐term results in a series of 30 patients

et al. 2018

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Background Glomus tumors are rare and benign hypervascular tumors. Surgery represented the mainstay of their treatment, even if it has been associated with high morbidity and mortality rates. Recently, the treatment shifted to a multimodal approach and Gamma Knife radiosurgery represents one of the treatment options. Methods Authors retrospectively analyzed the clinical and radiological outcome of a series of patients who underwent Gamma Knife radiosurgery for glomus tumors. Results Thirty patients underwent Gamma Knife radiosurgery. Mean tumor volume was 7.69 cc (range 0.36‐24.6). Mean tumor margin dose was 16 Gy (range 13‐18). Median follow‐up was of 91 months (mean 90; range 11‐172). Overall clinical control rate was 100%; overall volumetric tumor control rate was 96.6%. Patients' and tumors' characteristics, treatment data, and outcome have been analyzed. Conclusion Gamma Knife radiosurgery represents a safe and effective treatment for glomus tumors. Longer follow‐up and larger cohort studies are needed to definitively outline the role of Gamma Knife radiosurgery for glomus tumors.

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Section: Discussionmentioning

confidence: 99%

Gamma Knife radiosurgery for glomus tumors: Long‐term results in a series of 30 patients

et al. 2018

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“…In general, patients either maintain function of their cranial nerves or have improvement in their dysfunction after treatment but many of these studies included patients treated with multiple types of surgical and/or radiation treatment types. 6,12,13,22–26 Our study demonstrated overall stability of cranial nerve function using single modality GKRS. Those with lower cranial neuropathies were rehabilitated well (i.e.…”

Section: Discussionmentioning

confidence: 52%

Treatment Outcomes for Single Modality Management of Glomus Jugulare Tumors With Stereotactic Radiosurgery

Dobberpuhl

Maxwell²,

Feddock³

et al. 2016

Otology &Amp; Neurotology

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Objectives The objectives were to evaluate the audiological outcomes, response of symptoms, and response of tumor volume in patients with glomus jugulare tumors treated solely with single fraction gamma knife radiosurgery. Study Design Single institution retrospective review. Setting Academic, tertiary referral center. Patients The diagnosis code for glomus jugulare was used to identify patients. Only those who underwent gamma knife radiosurgery were included. Those previously treated with any modality were excluded. A total of 12 patients were included for the tumor response and symptom response data and 7 of those were included in the audiometric analysis. Main Outcomes Measures Audiometric data at most recent follow up compared to presentation, subjective improvement in pulsatile tinnitus, and change in tumor volume at most recent follow up compared to pretreatment. Results The average time to most recent follow up was 27.6 months. There was no significant change in pure tone average or word recognition. Pulsatile tinnitus completely resolved or improved in 80% of patients. Cranial neuropathies were stable or improved. A single patient experienced facial nerve paresis 2 years after treatment, which resolved with steroid treatment. Tumor control was 100% and the average change in tumor volume was a decrease of 37%. Conclusion Single modality Gamma Knife radiosurgery treatment of glomus jugulare tumors appears to be safe. Treatment results in decreased tumor volume and improved pulsatile tinnitus in most patients. There was no significant progression of hearing loss after treatment. Lower cranial nerve function remains stable in all patients.

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“…The 10-year survival rate of patients following conventional radiotherapy is 90-100% [33,34]. Stereotactic radiotherapy is useful for long-term control of small intracranial paragangliomas, but its effectiveness for spinal paragangliomas hasn't been examined [35]. It is recommended that a total of 45 Gy be given for paraganglioma lesions involving the spine [36].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and surgical treatment of spinal paraganglioma: A case series of 18 patients

Yin

Huan

Sun

et al. 2017

Clinical Neurology and Neurosurgery

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Successful treatment of glomus jugulare tumours with gamma knife radiosurgery: clinical and physical aspects of management and review of the literature

Cited by 45 publications

References 36 publications

Gamma Knife radiosurgery for glomus tumors: Long‐term results in a series of 30 patients

Gamma Knife radiosurgery for glomus tumors: Long‐term results in a series of 30 patients

Treatment Outcomes for Single Modality Management of Glomus Jugulare Tumors With Stereotactic Radiosurgery

Clinical characteristics and surgical treatment of spinal paraganglioma: A case series of 18 patients

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