Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus

Miyabe, Yoshishige; Murata, Yutaka; Baba, Yukari; Ito, Eisaku; Nagasaka, Kenji

doi:10.3109/s10165-011-0435-6

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Previously reports have shown efficacy with the administration of high-dose glucocorticoids and cyclosporine A [2,3,9]. There has been a report of cyclosporine-resistant CHP that was successfully treated with tacrolimus [10]. An additional report has identified intravenous immunoglobulins (IVIG) and cyclophosphamide as efficacious [6].…”

Section: Discussionmentioning

confidence: 99%

Cytophagic Histiocytic Panniculitis and Kikuchi-Fujimoto-Like Lymphadenitis in a Patient With Systemic Lupus Erythematosus

Moshayedi¹,

Shea²,

Nandan³

et al. 2022

Cureus

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A 54-year-old African American male with systemic lupus erythematosus and chronic alcoholic hepatitis presented with recurrent fever, pancytopenia, transaminitis, weight loss, and widespread violaceous tender plaques. Skin biopsy revealed hemophagocytic histiocytes leading to a diagnosis of cytophagic histiocytic panniculitis in the setting of lupus panniculitis. During workup, an axillary lymph node biopsy mimicked Kikuchi-Fujimoto's disease. Treatment with tapering high-dose glucocorticoids, mycophenolate mofetil, and hydroxychloroquine induced remission of the disease. We believe the comorbid conditions of Kikuchi-Fujimoto-like pathology and cytophagic histiocytic panniculitis have not been documented in the literature to date in a patient with systemic lupus erythematosus.

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Section: Discussionmentioning

confidence: 99%

Cytophagic Histiocytic Panniculitis and Kikuchi-Fujimoto-Like Lymphadenitis in a Patient With Systemic Lupus Erythematosus

Moshayedi¹,

Shea²,

Nandan³

et al. 2022

Cureus

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Systemic lupus erythematosus with cytophagic histiocytic panniculitis successfully treated with high-dose glucocorticoids and cyclosporine A

Hasegawa

Mizoguchi

Kohsaka

et al. 2013

Lupus

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A 37-year-old male with systemic lupus erythematosus (SLE) presented with high fever, subcutaneous indurations, anemia, thrombocytopenia, elevated liver enzymes and hyperferritinemia. Skin biopsy revealed hemophagocytic histiocytes in the adipose tissues. The patient was diagnosed with SLE with cytophagic histiocytic panniculitis (CHP). Treatment with high-dose glucocorticoids and cyclosporine A induced remission of SLE and CHP. CHP is generally a systemic disorder affecting subcutaneous adipose tissues with a high mortality rate. However, based on the present and previously reported cases, we believe that intensive immunosuppression can ameliorate CHP that occurs as a skin manifestation of SLE.

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Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis

Kaieda

Yoshida

Yamashita

et al. 2013

Modern Rheumatology

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Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchange therapy was effective in this case for treating MAS. This combination therapy is especially useful for MAS refractory to steroids.

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Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus

Cited by 3 publications

References 10 publications

Cytophagic Histiocytic Panniculitis and Kikuchi-Fujimoto-Like Lymphadenitis in a Patient With Systemic Lupus Erythematosus

Cytophagic Histiocytic Panniculitis and Kikuchi-Fujimoto-Like Lymphadenitis in a Patient With Systemic Lupus Erythematosus

Systemic lupus erythematosus with cytophagic histiocytic panniculitis successfully treated with high-dose glucocorticoids and cyclosporine A

Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis

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