Successful Treatment of Cutaneous Sarcoidosis Using Topical Photodynamic Therapy

Karrer, Sigrid; Abels, Christoph; Wimmershoff, M. B.; Landthaler, Míchael; Szeimies, Rolf‐Markus

doi:10.1001/archderm.138.5.581

Cited by 57 publications

(33 citation statements)

References 18 publications

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“…However this facility may not be available everywhere and the test is expensive to perform. Though numerous modalities of treatment are mentioned in literature, no consistently effective treatment of sarcoidosis exists 7 . Early treatment of cutaneous sarcoidosis is essential in order to prevent permanent scarring of the skin.…”

Section: Discussionmentioning

confidence: 99%

Lupus Pernio-A Rare Case Report

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Lupus Pernio-A Rare Case Report

et al. 2013

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“…Photodynamic production of singlet oxygen species is a promising treatment for killing bacteria (20,45) and for the removal of biofilms (48,49). As mentioned earlier, the DNP offers more advantages than traditional photodynamic meth- ods and has been successfully used to kill tumor cells in vitro (37) and in vivo (23,31).…”

Section: Discussionmentioning

confidence: 99%

“…It is worthwhile to mention that PDT will not only be effective in killing pathogenic bacteria but also in destroying certain secreted virulence factors (21). There have been several reports on the use of PDT to treat infections in selected animal models (15,16,24,39) and on some clinical trials for treatment of viral and bacterial infections (20,25,33,35,36).…”

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confidence: 99%

Eradication of Bacteria in Suspension and Biofilms Using Methylene Blue-Loaded Dynamic Nanoplatforms

Wu¹,

Tang

et al. 2009

Antimicrob Agents Chemother

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The bacterial killing efficiency of a dynamic nanoplatform (DNP) was evaluated. The polyacrylamide (PAA) hydrogel matrix of the DNP was loaded with methylene blue (MB) and was previously applied successfully to killing rat C6 glioma tumor cells in culture. This series of experiments is aimed at determining the suitability of this nanoplatform for elimination of bacterial infections. Suspended cultures of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter sp. were exposed to activated (ϳ650-nm laser light) MB-PAA-DNPs. The killing efficiency of nanoparticle mass concentration, light irradiance and fluence, and dark incubation time was determined on each of the bacterial species. Moreover, the ability of activated MB-PAA-DNPs to inhibit biofilm growth and eradicate and disperse preformed biofilms, preformed on glass and polystyrene surfaces, was demonstrated. The data revealed that activated MB-PAA-DNPs eradicated all species of bacteria examined. Also, encapsulation of MB into the PAA-DNP matrix significantly diminished the observed dark toxicity of free dye. The photobactericidal efficacy of MB-PAA-DNP was found to be higher for gram-positive bacteria than for gram-negative bacteria. In addition, activated MB-PAA-DNP can inhibit biofilm growth and eradicate almost all of the early-age biofilms that are formed by all of the bacteria examined.

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“…It might be speculated that during PDT in cutaneous sarcoidosis, selective destruction of cells crucial for the release of TNF-α and interleukin-1 by PDT-induced cellular toxins might change the cytokine environment and reduce the number of granuloma-forming CD4+ and CD8+ T cells, leading to the stepwise disorganization and dissolution of the granulomatous lesions [9, 10]. …”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy as an Alternative Treatment for Cutaneous Sarcoidosis

Wilsmann‐Theis¹,

Bieber²,

Novak³

2008

Dermatology

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Sarcoidosis is a systemic granulomatous disease. In more than 90% of the cases, sarcoidosis affects the lung with bilateral hilar adenopathy, while skin involvement occurs in about 25% of the cases. Whereas sarcoidosis of the lung is often successfully treated with oral corticosteroids, therapy of cutaneous sarcoidosis is frequently frustrating because some of the lesions may be refractory to treatment or recur quickly after resolution. We report two cases of cutaneous sarcoidosis successfully treated with photodynamic therapy, which represents an effective alternative therapy with fewer side effects.

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Successful Treatment of Cutaneous Sarcoidosis Using Topical Photodynamic Therapy

Cited by 57 publications

References 18 publications

Lupus Pernio-A Rare Case Report

Lupus Pernio-A Rare Case Report

Eradication of Bacteria in Suspension and Biofilms Using Methylene Blue-Loaded Dynamic Nanoplatforms

Photodynamic Therapy as an Alternative Treatment for Cutaneous Sarcoidosis

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