Successful treatment of confluent and reticulated papillomatosis with topical mupirocin

Konfluent Ve Reti̇küler Papi̇llomaztozi̇sli̇ İki̇ Olgu Sunumu

“…Her iki olgumuzdan da hazırlanan kazıma preparatında mantar spor ve hif yapıları gözlenmemiştir. Buna ilaveten akantozis nigrikans, Resim 5: Olgu 2'nin meme arasında ve bilateral meme altlarında koyu kahverengi, kadifemsi, papül ve plaklar prurigo pigmentosa, Darier hastalığı, epidermal nevüs, kutanöz amiloidoz, Dowling-Degos hastalığı, iktiyozis, seboreik dermatit ve parapsoriazis gibi hastalıklar da ayırıcı tanıda akla gelmelidir (3,4,11). KRP, bozulmuş glukoz toleransı, hiperinsülinemi, hipotiroidizm, diabetes mellitus ve polikistik over sendromu gibi bazı endokrin anormallikler ile birlikte gözlenebilmektedir (12).…”

Successful treatment of confluent and reticulated papillomatosis with tetracycline and mupirocin

“…Histopathological examination reveals mild hyperkeratosis, papillomatosis, focal acanthosis and superficial perivascular lymphocytic infiltration. Although some treatment options such as salicylic acid, urea, topical and systemic retinoid, topical calcipotriol, tacrolimus, tazarotene, fluorouracil, antifungals, phototherapy and dermabrasion can be used, some studies of CRP performed in recent years have focused on the role of bacteria in the pathogenesis 1,[5][6][7] . Good response to antibiotics such as minocycline and azithromycin in clinical practice reinforces this theory.…”

“…Therefore, antibiotics with anti-inflammatory effect are effective and a first-line treatment option in CRP. Thus, we selected tetracycline treatment with antimicrobial support of mupirocin which reduces epidermal proliferation by blocking of protein and DNA synthesis 5 . Complete remission was obtained in our patient after a 2-week oral tetracycline and topical mupirocin treatment.…”

Confluent and reticulated papillomatosis subsiding spontaneously after delivery: Report of one case

“…Minocycline is considered as first line, but is considered category D and not recommended in pregnancy. Azythromycin, erythromycin, fucidic acid, tetracycline and cefdinir as well as topical mupirocin were also reported to be effective 3,11 . Other kinds of treatment reported to be successful include keratolytics, retinoids, vitamin D analogues, oral contraceptives, propylthiouracil, sodium thiosulphate, ammoniated mercury, thyroid extract, ultraviolet light, propylene glycol, antimycotics, and 70% alcohol.…”