Successful treatment of acquired cutis laxa with urticarial eruption by diphenyl sulfone

Zheng, Bin; Yan, Yuting; Ou, Minglin; Wang, X H

doi:10.1111/ced.14451

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…However, in the study of the dapsone effect in antihistamine refractory chronic idiopathic urticaria, VRDs occurred in only three patients in the placebo group (Morgan et al 2014 ). A higher dose of dapsone was required when the patient developed a tracheal infection, but the patient had no similar VRDs (Zheng et al 2021 ). We correlated dapsone to compete with the NLRP3 inflammasome (Lee et al 2020a ).…”

Section: Methodsmentioning

confidence: 99%

Bronchitis, COPD, and pneumonia after viral endemic of patients with leprosy on Sorok Island in South Korea

Lee

Kanwar

Khattak

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Viral respiratory diseases (VRDs) cause lung inflammation and inflammatory cytokine production. We study whether dapsone is responsible for its observed preventive treatment effects of the sustained viral RNA interferon response. Around 2008 and 2012, Korea’s Dementia Management Act stipulated drastic changes in the administration of dementia medication by medical staff. Participants were randomized and we compared leprosy patients with VRDs after prescribing dapsone as a standard treatment from 2005 to 2019. Significance was evaluated based on the dapsone-prescribed (+) subgroup and the dapsone-unprescribed (−) subgroup of the VRD diagnosed (+) and VRD undiagnosed (−) subgroup. We analyzed VRD ( +)/(− with dapsone (+)/(−) group and used a T-test, and designed the equation of acetylation with dapsone and acetylcholine (AA) equation. The 6394 VRD participants who received the dapsone intervention compared to the 3255 VRD participants in the control group demonstrated at T2 VRD (+) dapsone (−) (mean (M) = 224.80, SD = 97.50): T3 VRD (−) dapsone (+) (M = 110.87, SD = 103.80), proving that VRD is low when dapsone is taken and high when it is not taken. The t value is 3.10, and the p value is 0.004395 (significant at p < 0.05). After an increase in VRDs peaked in 2009, bronchitis, COPD, and pneumonia surged in 2013. The AA equation was strongly negatively correlated with the prevalence of bronchitis and chronic obstructive pulmonary disease (COPD): with bronchitis, r(15) = −0.823189, p = 0.005519, and with COPD, r(15) = −0.8161, p = 0.000207 (significant at p < 0.05). Dapsone treated both bronchitis and COPD. This study provides theoretical clinical data to limit acetylcholine excess during the VRD pandemic for bronchitis, COPD, and pneumonia.

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Section: Methodsmentioning

confidence: 99%

Bronchitis, COPD, and pneumonia after viral endemic of patients with leprosy on Sorok Island in South Korea

Lee

Kanwar

Khattak

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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“…3 Chronic urticaria, dermatitis herpetiformis, Sweet syndrome, sarcoidosis, mastocytosis, and connective tissue disease are among the causative factors of ACL. 3 Recently, Zheng et al 5 and Takenaka et al 6 reported two very similar cases of generalized ACL developing in the setting of urticarial eruption, which were successfully treated with diphenyl sulfone. In the case of urticaria, infiltration of the neutrophils into the elastic fibers, increased elastase activity and dysfunction of elastase inhibitors, may cause fragmentation, thinning, and disorganization in ACL.…”

Section: Chronic Urticaria May Not Be As Innocent As We Think: a Rare...mentioning

confidence: 99%

“…In the case of urticaria, infiltration of the neutrophils into the elastic fibers, increased elastase activity and dysfunction of elastase inhibitors, may cause fragmentation, thinning, and disorganization in ACL. [5][6][7] Since dapsone inhibits calcium-dependent activities of neutrophils, therapeutic management may be achieved by the use of dapsone. 8 By looking at the examples of successful treatment with dapsone in ACL patients, we chose to start with dapsone.…”

Section: Chronic Urticaria May Not Be As Innocent As We Think: a Rare...mentioning

confidence: 99%

Chronic urticaria may not be as innocent as we think: A rare case of acquired cutis laxa following chronic urticaria

Bostan

Yalıcı-Armağan

Gököz

2021

J of Cosmetic Dermatology

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Acquired cutis laxa secondary to acute generalized exanthematous pustulosis: A case report and mini‐review of literature

Yamashita

Fukui

Akasaka

et al. 2023

The Journal of Dermatology

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Cutis laxa presents as loose redundant skin folds and loss of dermal elastic tissue. Acquired cutis laxa (ACL) is characterized by later onset. It has been reported in association with various kinds of neutrophilic dermatoses, drugs, metabolic disorders, and autoimmune disorders. Acute generalized exanthematous pustulosis (AGEP) is usually classified as a severe cutaneous adverse reaction characterized by T cell–mediated neutrophilic inflammation. We previously reported a mild case of AGEP caused by gemcitabine in a 76‐year‐old man. Here, we report a case of ACL secondary to AGEP in this patient. He developed AGEP 8 days after gemcitabine administration. Four weeks after beginning chemotherapy, his skin had become atrophic, loose, and darkly pigmented in areas previously affected by AGEP. Histopathological examination revealed edema and perivascular lymphocytic infiltration but no neutrophilic infiltration in the upper dermis. Elastica van Gieson staining showed that the elastic fibers in all layers of the dermis were sparse and shortened. Electron microscopy showed elevated numbers of fibroblasts and altered elastic fibers with irregular surfaces. Finally, he was diagnosed with ACL secondary to AGEP. He was treated with topical corticosteroids and oral antihistamines. Skin atrophy decreased over 3 months. We summarize 36 cases (including our case) with ACL secondary to neutrophilic dermatosis. We discuss these clinical manifestations, causative neutrophilic disorders, treatments, and outcomes. The mean age of patients was 3.5 years. Five patients had an aortic lesion as systemic involvement. The most common causative neutrophilic disorders were Sweet syndrome (24 cases), followed by urticaria‐like neutrophilic dermatosis (11 cases). There were no cases of AGEP except for our case. Although treatment for ACL secondary to neutrophilic dermatosis, such as dapsone, oral prednisolone, adalimumab, and plastic surgery were reported, ACL is generally refractory and irreversible. Our patient was considered reversibly cured due to the absence of continuous neutrophil‐mediated elastolysis.

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Successful treatment of acquired cutis laxa with urticarial eruption by diphenyl sulfone

Abstract: Click https://www.wileyhealthlearning.com/Activity/7155927/disclaimerspopup.aspx for the corresponding questions to this CME article.

Cited by 4 publications

References 9 publications

Bronchitis, COPD, and pneumonia after viral endemic of patients with leprosy on Sorok Island in South Korea

Bronchitis, COPD, and pneumonia after viral endemic of patients with leprosy on Sorok Island in South Korea

Chronic urticaria may not be as innocent as we think: A rare case of acquired cutis laxa following chronic urticaria

Acquired cutis laxa secondary to acute generalized exanthematous pustulosis: A case report and mini‐review of literature

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