Successful testicular sperm extraction in Korean Klinefelter syndrome

Seo, Ju Tae; Park, Yong Seog; Lee, Joong Shik

doi:10.1016/j.urology.2004.07.013

Cited by 37 publications

(31 citation statements)

References 15 publications

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“…Spermatozoa were also successfully found in 70% of ejaculated semen samples of adolescent males aged 12-20 years (Mehta & Paduch, 2012). Despite all that, several papers failed to find a significant difference in SSR with respect to age (Seo et al, 2004;Vernaeve et al, 2004;Schiff et al, 2005;Koga et al, 2007;Selice et al, 2010). In this study, age was also not found to have any statistically significant influence on SSR (P = 0.42).…”

Section: Discussionmentioning

confidence: 50%

Outcome of testicular sperm extraction in nonmosaic Klinefelter syndrome patients: what is the best approach?

et al. 2015

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Klinefelter syndrome (KS) is the most common chromosomal disorder associated with male hypogonadism and infertility. Parenthood can be achieved in men with KS by intracytoplasmic sperm injection (ICSI) using testicular spermatozoon. The aim of this study was to evaluate surgical sperm retrieval (SSR) rate in patients with KS and to investigate the approach associated with the highest SSR. This is a retrospective study where all medical records of patients with KS who underwent SSR for ICSI, in our centre in the past 14 years, were reviewed. Forty-three patients were included in this study. Twenty-three underwent conventional testicular sperm extraction (TESE), while 20 patients underwent microsurgical TESE (Micro-TESE). The SSR was significantly higher in the Micro-TESE group when compared with the TESE group (30% versus 0% respectively). In the Micro-TESE group, hormonal stimulation was given to 16 patients, while no treatment was given to four patients. SSR was only successful in hormonally treated patients (6/16). When the type of hormone stimulation was evaluated, SSR was higher in patients receiving aromatase inhibitors (27.8%). SSR in patients with KS is significantly higher when using hormonal stimulation by aromatase inhibitors followed by microsurgical testicular sperm extraction.

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Section: Discussionmentioning

confidence: 50%

Outcome of testicular sperm extraction in nonmosaic Klinefelter syndrome patients: what is the best approach?

et al. 2015

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“…Notably, the literature search revealed the lack of any randomized controlled trial evaluating the impact of HT on sperm retrieval or reproductive outcomes in men with KS. Table 1 summarizes the success rates and predictors of sperm retrieval from men with KS, based on data published to date (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). Although the focus was on patients with nonmosaic KS, the report from Schiff et al (37) was included because of the low proportion (7%) of mosaic KS patients and similar sperm retrieval outcomes between mosaic and nonmosaic patients.…”

Section: Resultsmentioning

confidence: 99%

“…A higher pregnancy rate (PR) after ICSI has been reported with the use of freshly retrieved sperm (27,37). However, cryopreserved sperm have been successfully used by several groups (28,29,35), obviating the need for repeat surgical procedures for sperm retrieval.…”

Section: Figurementioning

confidence: 99%

Klinefelter syndrome: an argument for early aggressive hormonal and fertility management

Mehta

Paduch

2012

Fertility and Sterility

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“…A total of 741 patients were included with an average sperm retrieval rate of 50% distributed on 42% by the use of TESE and 57% by the use of micro-TESE (56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77). A total of 14 mosaics were included in these studies (56,72). Exclusion of these did not change the success rates.…”

Section: A New Sperm Retrieval Methodsmentioning

confidence: 99%

“…However, in two recent studies of nonmosaic KS patients all meiotic spermatocytes were normally euploid and thus able to mature into haploid spermatozoa (25,103). Thus, at least 149 healthy live born babies without anomalies were conceived after TESE/ICSI from couples, including a 47,XXY father, have been reported worldwide (13,48,52,56,58,59,60,61,63,64,65,67,68,69,70,72,74,75,100,104,105,106,107,108).…”

Section: Outcome Of Tese/icsi In 47xxymentioning

confidence: 99%

Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

Aksglæde

Juul

2013

European Journal of Endocrinology

169

114

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Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia in the majority of cases. Until recently, infertility was considered an untreatable condition in KS. However, with the development of new advanced assisted reproductive techniques such as testicular sperm extraction (TESE) combined with ICSI it seems that KS patients should no longer be labelled as infertile. Especially, microdissection (micro)-TESE has proved to be an advantageous procedure for the identification of testicular spermatozoa in KS. The aim of this review was to describe current knowledge on the testicular changes occurring in KS, the associated changes in reproductive hormones and spermatogenesis, and the existing possibilities of biological fatherhood in 47,XXY patients. European Journal of Endocrinology 168 R67-R76

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Successful testicular sperm extraction in Korean Klinefelter syndrome

Cited by 37 publications

References 15 publications

Outcome of testicular sperm extraction in nonmosaic Klinefelter syndrome patients: what is the best approach?

Outcome of testicular sperm extraction in nonmosaic Klinefelter syndrome patients: what is the best approach?

Klinefelter syndrome: an argument for early aggressive hormonal and fertility management

Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

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