Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

Aksglæde, Lise; Juul, Anders

doi:10.1530/eje-12-0934

Cited by 169 publications

(135 citation statements)

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“…3 Examples of causes of Sertoli cell only syndrome may include genetic factors, hormonal factors, idiopathic factors, varicocele, toxin exposure, history of radiation therapy, and history of severe trauma. [4][5][6] Endocrine malfunctions are more prevalent in infertile men than in the general population, but still quite uncommon. Abnormalities of the hypothalamic-pituitary-testicular axis at the testicular level cause primary testicular failure, whereas central defects of the hypothalamus or pituitary cause secondary testicular failure.…”

Section: Introductionmentioning

confidence: 99%

Testosterone and Gonadotropins in Infertile Men with Sertoli Cell Only Syndrome from Gaza Strip

et al. 2017

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Abstract Abstract Abstract Aim: Aim: Aim: Aim: Aim: To assess serum testosterone and gonadotropins in Sertoli cell only syndrome patients from Gaza Strip.Methods: Methods: Methods: Methods: Methods: Based on testicular biopsy, a cross section of 74 Sertoli cell only syndrome patients were enrolled in the study. Age matched 44 fertile men were served as controls. Patients and controls were questioned for their medical history. Blood samples were drawn and serum testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were determined by enzyme-linked immunosorbent assay. Data were computer analyzed using SPSS/PC, version 18.0. Results:Results: Results: Results: Results: Varicocele and hormonal problems were significantly more frequent among patients than controls (P<0.05). Serum testosterone was significantly lower in patients compared to controls (1.7±1.3 versus 5.0±2.2 ng/ml, P=0.000). In contrast, LH and FSH were significantly higher in patients than controls (12.8±9.7 and 20.8±14.8 mlU/ml versus 6.3±3.1 and 7.7±3.9 mlU/ml, P=0.000, respectively). Hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism patients showed lower levels of testosterone compared to the normal reference value (0.9±0.5 and 0.5±0.4 ng/ml versus 2.0-7.0 ng/ml). Higher levels of LH and FSH were recorded in hypergonadotrophic hypogonadism (24.5±2.6 and 37.4±6.7 mlU/ml) compared to the reference values of 2.0-13.0 and 2.5-10.0 mlU/ml, respectively whereas LH and FSH levels were lower in hypogonadotrophic hypogonadism (0.6±0.4 and 0.6±0.5 mlU/ml, respectively). In this context, all hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism patients showed abnormal levels of testosterone, LH and FSH. Conclusions:Conclusions: Conclusions: Conclusions: Conclusions: Abnormal levels of serum testosterone, LH and FSH, particularly in hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism were identified in infertile men with Sertoli cell only syndrome from Gaza Strip. K K K K Ke e e e eyw yw yw yw ywor or or

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Section: Introductionmentioning

confidence: 99%

Testosterone and Gonadotropins in Infertile Men with Sertoli Cell Only Syndrome from Gaza Strip

et al. 2017

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“…In the phenotypically male patients, sex chromosome DSDs present as Klinefelter syndrome (47, XXY). Klinefelter syndrome occurs in around 1:660 newborn boys and is characterised by progressive testicular failure, causing small firm testes which are azoospermic (Aksglaede and Juul, 2013).…”

Section: Sex Chromosome Dsdmentioning

confidence: 99%

Textbook of Plastic and Reconstructive Surgery

Butler¹,

Ghali²,

Kalaskar³

2016

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A CIP catalogue record for this book is available from The British Library.This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. The user is advised to always check the product information and clinical procedures with the most up-to-date published product information and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or misuse or misapplication of material in this work.ISBN: 978-1-910634-37-0 (Hbk.) ISBN: 978-1-910634-38-7 (Pbk.) ISBN: 978-1-910634-39-4 (PDF) ISBN: 978-1-910634-40-0 (epub) ISBN: 978-1-910634-41-7 (mobi)

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“…The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia leading to primary male infertility. 10,11 Ring chromosome may affect the AZF regions of Y chromosome resulting in testicular failure with azoospermia or oligozoospermia. 12 Lumenfeed B et al 13 investigated the causes and problems of the infertility in 1993.…”

Section: Review Of Literaturesmentioning

confidence: 99%

A Chromosomal Karyotyping Study in Male With Primary Infertility in a Western West Bengal Population

Ray¹,

Mandal²,

Goswami³

et al. 2016

jemds

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Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

Cited by 169 publications

References 112 publications

Testosterone and Gonadotropins in Infertile Men with Sertoli Cell Only Syndrome from Gaza Strip

Testosterone and Gonadotropins in Infertile Men with Sertoli Cell Only Syndrome from Gaza Strip

Textbook of Plastic and Reconstructive Surgery

A Chromosomal Karyotyping Study in Male With Primary Infertility in a Western West Bengal Population

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