Successful TB treatment outcome and its associated factors among TB/HIV co-infected patients attending Gondar University Referral Hospital, Northwest Ethiopia: an institution based cross-sectional study

Abstract

BackgroundTuberculosis/Human immunodeficiency virus (TB/HIV) co-infection is bidirectional and synergistic which mainly affects interventions that have been taken on the area. Tb patients co-infected with HIV have poorer treatment outcome as compared to non-co-infected patients. There is limited information regarding successful TB treatment outcomes and its associated factors; a reason that this study was planned to investigate.MethodsAn institution based cross sectional study was carried out from July 2010 to January 2016. Data were abstracted from patients’ medical chart using data abstraction format. The completeness of the data was checked and cleaned manually. Then, it was entered and analyzed by using SPSS version 20.0. Bi-variable and Multi-variable logistic regression model was fitted to identify factors associated with successful Tb treatment outcome. Significance was obtained through adjusted odds ratio with its 95% CI and a p < 0.05.ResultsSuccessful TB treatment outcome among TB/HIV co-infected patients in Gondar University Hospital was 77.3% [95%CI 72.6–81.9]. Being residing in outside the Gondar town [AOR = 0.44, 95%CI: 0.25–0.80], having less than the mean baseline weight (<43.7 kg) at initiation of TB treatment [AOR = 0.51, 95% CI: 0.29–0.89], being in the bedridden condition [AOR = 0.23, 95% CI: 0.1–0.23], and experiencing anti-TB treatment side effect [AOR = 0.35, 95% CI: 0.12–0.98] were the factors that resulted the patient in treatment failure.ConclusionSuccessful Tb treatment outcome among TB/HIV co-infected patients was lower than the target set by Global Plan to Stop TB 2011–2015. Strengthening collaborative TB/HIV management activities that would trace the identified factors shall be recommended to increase successful treatment outcome of TB.

Human immunodeficiency virus as a determinant of tuberculosis treatment outcome in tuberculosis patients treated at Arba Minch General Hospital: a five-year retrospective study

“…Overall, TSR of registered TB patients with and without HIV was 74.6%, which is inconsistent with the WHO target of 85% [9] and EMoH target of 97% [7]. However, our finding is consistent with the previous report for Tigray [17], Gondor [18] and western Ethiopia [19]. The TSR was worse in tuberculosis patients with HIV than without HIV.…”

Homelessness and HIV: A Combination Predictive of Poor Tuberculosis Treatment Outcomes and in Need of Innovative Strategies to Improve Treatment Completion

“…Higher rates of failure among patients previously treated for TB have been illustrated by others. [22][23][24][25] A cohort study on homeless patients with TB in Poland found that a significant number of homeless TB patients had been treated for TB in the past compared with non-homeless patients. 21 In that study, homeless patients also had lower rates of treatment success, although the study did not differentiate patients according to HIV status.…”

Predictors of tuberculosis treatment success under the DOTS program in Namibia

“…Previous studies have associated high rates of death and defaulting among TB patients to be due to the inappropriate choice of TB regimens 37,38 , HIV co-infection 39,40 , adverse drug effects [41][42][43] and the lack of screening and monitoring systems 6,18,44,45 .…”