Successful surgical repair of a false aneurysm of the ascending aorta following orthotopic cardiac transplantation: a case report

Punjabi, Prakash P; Murday, A. J.

doi:10.1016/s1010-7940(97)01152-4

Cited by 8 publications

(2 citation statements)

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“…DNA Polymerase Epsilon 2, Accessory Subunit (POLE2) is highly involved in DNA repair and replication. It has been previously reported to have a high association with colorectal cancer [40]. In this study, POLE2 is ranked as the second highest target.…”

Section: Potential Target Subnetwork and Targets Ranked By Scnrankmentioning

confidence: 68%

SCNrank: spectral clustering for network-based ranking to reveal potential drug targets and its application in pancreatic ductal adenocarcinoma

et al. 2020

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Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy. Due to its wide heterogeneity, PDAC acts aggressively and responds poorly to most chemotherapies, causing an urgent need for the development of new therapeutic strategies. Cell lines have been used as the foundation for drug development and disease modeling. CRISPR-Cas9 plays a key role in every step-in drug discovery: from target identification and validation to preclinical cancer cell testing. Using cell-line models and CRISPR-Cas9 technology together make drug target prediction feasible. However, there is still a large gap between predicted results and actionable targets in real tumors. Biological network models provide great modus to mimic genetic interactions in real biological systems, which can benefit gene perturbation studies and potential target identification for treating PDAC. Nevertheless, building a network model that takes cell-line data and CRISPR-Cas9 data as input to accurately predict potential targets that will respond well on real tissue remains unsolved. Methods: We developed a novel algorithm 'Spectral Clustering for Network-based target Ranking' (SCNrank) that systematically integrates three types of data: expression profiles from tumor tissue, normal tissue and cell-line PDAC; protein-protein interaction network (PPI); and CRISPR-Cas9 data to prioritize potential drug targets for PDAC. The whole algorithm can be classified into three steps: 1. using STRING PPI network skeleton, SCNrank constructs tissuespecific networks with PDAC tumor and normal pancreas tissues from expression profiles; 2. With the same network skeleton, SCNrank constructs cell-line-specific networks using the cell-line PDAC expression profiles and CRISPR-Cas 9 data from pancreatic cancer cell-lines; 3. SCNrank applies a novel spectral clustering approach to reduce data dimension and generate gene clusters that carry common features from both networks. Finally, SCNrank applies a scoring scheme called 'Target Influence score' (TI), which estimates a given target's influence towards the cluster it belongs to, for scoring and ranking each drug target.

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Section: Potential Target Subnetwork and Targets Ranked By Scnrankmentioning

confidence: 68%

SCNrank: spectral clustering for network-based ranking to reveal potential drug targets and its application in pancreatic ductal adenocarcinoma

et al. 2020

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“…Pseudoaneurysms of the ascending aorta following previous thoracic surgery have been reported following various types of surgery involving ascending aorta, including aortic dissection repair [1], aortic valve replacement [2], orthotopic cardiac transplantation [3], and coronary artery bypass graft surgery [4]. Although rare, they may form at the site of aortic cannulation, aortomy, or aortic anastomoses.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous closure of ascending aortic pseudoaneurysm using Amplatzer septal occluder device: The first clinical case report and literature review

Bashir

Quaife

Carroll

2005

Cathet. Cardiovasc. Intervent.

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We report the first case of the use of an Amplatzer septal occluder device to close a large ascending aortic pseudoaneurysm. The patient had a complex cardiac history with redo coronary artery bypass graft surgery, severe left ventricular dysfunction, and end-stage renal disease requiring hemodialysis. The procedure was successfully performed under fluoroscopic and 2D/3D transthoracic echocardiographic guidance. Six-week follow-up with both transthoracic echocardiography and MRI showed the device was in proper position with complete closure of the pseudoaneurysm.

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Aortic Root Aneurysm Due to Donor Cystic Medial Degeneration After Heart–Lung Transplantation

Nwakanma

Conte

Robbins

2006

The Journal of Heart and Lung Transplantation

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Successful surgical repair of a false aneurysm of the ascending aorta following orthotopic cardiac transplantation: a case report

Cited by 8 publications

References 0 publications

SCNrank: spectral clustering for network-based ranking to reveal potential drug targets and its application in pancreatic ductal adenocarcinoma

SCNrank: spectral clustering for network-based ranking to reveal potential drug targets and its application in pancreatic ductal adenocarcinoma

Percutaneous closure of ascending aortic pseudoaneurysm using Amplatzer septal occluder device: The first clinical case report and literature review

Aortic Root Aneurysm Due to Donor Cystic Medial Degeneration After Heart–Lung Transplantation

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