Successful Reorganization of Category-Selective Visual Cortex following Occipito-temporal Lobectomy in Childhood

Tt, Liu; Nestor, Adrian; Vida, Mark D.; Pyles, John A.; Patterson, Christina; Yang, Ying; Yang, Fan Nils; Freud, Erez; Behrmann, Marlene

doi:10.1016/j.celrep.2018.06.099

Cited by 35 publications

(42 citation statements)

References 48 publications

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“…In sum, the results from FC of visual ROIs revealed that, for both control and patient groups, the between-category ROI FC was weaker than the within-category ROI FC, be it in the combined or positive FC, and that the FC of LH in controls was the same as the FC of the RH (except in NN, with extant polymicrogyria and low IQ pre-surgically; and in JF, with a very large resection). These results are consistent with previous findings of normal neural responses and category-selectivity (Liu et al, 2018, Liu, Freud et al, 2019. The normal correlation profiles of the patients serve as validation that the data quality is sound and that we can replicate the expected result in which cortical regions that serve the same function are positively co-activated.…”

Section: Voxel-wise Fc Across Functional Roissupporting

confidence: 91%

“…Additionally, functional magnetic resonance imaging (fMRI) studies of such cases revealed normal activation profiles in response to different visual categories (e.g. faces and places) in the preserved cortical areas (Liu et al, 2018, Liu, Freud et al, 2019, as determined by the magnitude of selectivity, number of voxels, spatial organization of regions of interest (ROIs), and representational similarity analysis. It can be inferred from these studies that the homotopic regions in the preserved hemisphere assume the cognitive load of the resected tissue and that this occurs without any obvious cost ('crowding', Teuber 1975) to the overall cortical functional capacity (Beharelle et al, 2010;Wilke et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

Maallo

Granovetter

Freud

et al. 2020

Preprint

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AbstractDespite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.

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Section: Voxel-wise Fc Across Functional Roissupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

Maallo

Granovetter

Freud

et al. 2020

Preprint

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“…In a detailed longitudinal study over a period of 3 years, we monitored changes in behavior as well as EVC and category-selectivity in patient, U.D., with an extensive right occipitotemporal resection (Table 1). Whereas there was no visual field remapping and a persistent hemianopia, object-and scene-selective regions in the intact LH were stable early on and retained their stability, whereas face-selective regions emerged slightly later and evinced competition for cortical representation with word-selective regions in the preserved LH during this period (Liu et al, 2018). We note here that the reported plasticity of the left VOTC in patient U.D.…”

Section: Conclusion and Further Considerationsmentioning

confidence: 49%

“…We predicted that, similar to other cognitive functions which recover post-resection, children will largely, if not entirely, regain normal perceptual behavior, especially for behaviors that typically undergo a protracted developmental trajectory, such as face and word recognition (Liu et al, 2018). Importantly, however, this preserved or recovered behavior might be the product of the reorganization of the behaviors typically subserved by the resected regions to other ipsilesional or contralesional locations.…”

Section: Introductionmentioning

confidence: 98%

“…Because there is greater plasticity in childhood than in adulthood, such investigations offer a unique opportunity to uncover the organization of complex brain-behavior relationships and their plasticity (Bourne, 2010). Surprisingly, despite the importance of visual functions such as face and word recognition and the large swath of cortex implicated in these processes, rather few studies explore the impact of a cortical resection on visual behavior and on the organization of the VOTC (for recent single case studies, see Weiner et al, 2016;Liu et al, 2018). Here, we examine brainbehavior relationships in vision by combining psychophysics and functional imaging methods in a relatively large series of 10 postlobectomy children or adolescents (age 6 -17 years at surgery).…”

Section: Introductionmentioning

confidence: 99%

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Perceptual Function and Category-Selective Neural Organization in Children with Resections of Visual Cortex

Freud

Patterson

et al. 2019

J. Neurosci.

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The consequences of cortical resection, a treatment for humans with pharmaco-resistant epilepsy, provide a unique opportunity to advance our understanding of the nature and extent of cortical (re)organization. Despite the importance of visual processing in daily life, the neural and perceptual sequellae of occipitotemporal resections remain largely unexplored. Using psychophysical and fMRI investigations, we compared the neural and visuoperceptual profiles of 10 children or adolescents following unilateral cortical resections and their age-and gender-matched controls. Dramatically, with the exception of two individuals, both of whom had relatively greater cortical alterations, all patients showed normal perceptual performance on tasks of intermediate-and high-level vision, including face and object recognition. Consistently, again with the exception of the same two individuals, both univariate and multivariate fMRI analyses revealed normal selectivity and representational structure of category-selective regions. Furthermore, the spatial organization of categoryselective regions obeyed the typical medial-to-lateral topographic organization albeit unilaterally in the structurally preserved hemisphere rather than bilaterally. These findings offer novel insights into the malleability of cortex in the pediatric population and suggest that, although experience may be necessary for the emergence of neural category-selectivity, this emergence is not necessarily contingent on the integrity of particular cortical structures.

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Dissociated face- and word-selective intracerebral responses in the human ventral occipito-temporal cortex

Hagen

Lochy

Jacques³

et al. 2021

Brain Struct Funct

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The extent to which faces and written words share neural circuitry in the human brain is actively debated. Here, we compare face-selective and word-selective responses in a large group of patients (N = 37) implanted with intracerebral electrodes in the ventral occipito-temporal cortex (VOTC). Both face-selective (i.e., significantly different responses to faces vs. non-face visual objects) and word-selective (i.e., significantly different responses to words vs. pseudofonts) neural activity is isolated with frequency-tagging. Critically, this sensitive approach allows to objectively quantify category-selective neural responses and disentangle them from general visual responses. About 70% of significant electrode contacts show either face-selectivity or word-selectivity only, with the expected right and left hemispheric dominance, respectively. Spatial dissociations are also found within core regions of face and word processing, with a medio-lateral dissociation in the fusiform gyrus (FG) and surrounding sulci, respectively. In the 30% of overlapping face- and word-selective contacts across the VOTC or in the FG and surrounding sulci, between-category-selective amplitudes (faces vs. words) show no-to-weak correlations, despite strong correlations in both the within-category-selective amplitudes (face–face, word–word) and the general visual responses to words and faces. Overall, these observations support the view that category-selective circuitry for faces and written words is largely dissociated in the human adult VOTC.

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Successful Reorganization of Category-Selective Visual Cortex following Occipito-temporal Lobectomy in Childhood

Cited by 35 publications

References 48 publications

All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

Perceptual Function and Category-Selective Neural Organization in Children with Resections of Visual Cortex

Dissociated face- and word-selective intracerebral responses in the human ventral occipito-temporal cortex

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