Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases

Müller, V; Obyedkova, Ksenia V.; Krikheli, Inna O.; Kogan, Igor Yu.; Федорова, И. М.; Lesik, Elena A.; Komarova, Evgenia M.; Gzgzyan, Alexandr

doi:10.1155/2016/4391537

Cited by 10 publications

(12 citation statements)

References 16 publications

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“…Among all autoimmune diseases associated with POF, thyroid disorders are the most common [14]. It has been proposed that reduced fertility might be associated with the dysregulation of immune system reactions resulting in enhancement of autoantibody production [15]. This autoimmunity increases miscarriage risks, reduces female fecundity and infertility treatment success.…”

Section: Discussionmentioning

confidence: 99%

Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

Catteau

Bach-Ngohou

Blin

et al. 2019

Case Reports in Endocrinology

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We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.

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Section: Discussionmentioning

confidence: 99%

Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

Catteau

Bach-Ngohou

Blin

et al. 2019

Case Reports in Endocrinology

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“…Cases of anti-hCG autoimmunity have been described, where patients have a history of repeated attempts to perform unsuccessful IVF treatments (144). The beta subunit of hCG is not immunogenic in women (145).…”

Section: Autoimmunity To Hcg?mentioning

confidence: 99%

“…In this context, a structural alteration, due to a mutation in one of the beta-hCG genes and/or a functional abnormality of the immune system, could be implicated. In one case of infertility described with hCG immunization, pregnancy was achieved as a result of plasmapheresis treatment to detoxify the patient's body (144). Immunotherapy could be beneficial for patients who suffered from repeated implantation failures (RIFs) previously.…”

Section: Autoimmunity To Hcg?mentioning

confidence: 99%

Human Chorionic Gonadotrophin: New Pleiotropic Functions for an “Old” Hormone During Pregnancy

et al. 2020

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Human chorionic gonadotrophin (hCG) is the first specific molecule synthesized by the embryo. hCG RNA is transcribed as early as the eight-cell stage, and the blastocyst produces the protein before its implantation. hCG in the uterine microenvironment binds with its cognate receptor, luteinizing hormone/choriogonadotropin receptor (LHCGR), on the endometrial surface. This binding stimulates leukemia inhibitory factor (LIF) production and inhibits interleukin-6 (IL-6) production by epithelial cells of the endometrium. These effects ensure essential help in the preparation of the endometrium for initial embryo implantation. hCG also effects angiogenic and immunomodulatory actions as reported in many articles by our laboratories and other ones. By stimulating angiogenesis and vasculogenesis, hCG provides the placenta with an adequate maternal blood supply and optimal embryo nutrition during the invasion of the uterine endometrium. The immunomodulatory properties of hCG are numerous and important for programming maternal immune tolerance toward the embryo. The reported effects of hCG on uterine NK, Treg, and B cells, three major cell populations for the maintenance of pregnancy, demonstrate the role of this embryonic signal as a crucial immune regulator in the course of pregnancy. Human embryo rejection for hCG-related immunological reasons has been studied in different ways, and a sufficient dose of hCG seems to be necessary to maintain maternal tolerance. Different teams have studied the addition of hCG in patients suffering from recurrent miscarriages or implantation failures. hCG could also have a beneficial or a negative impact on autoimmune diseases during pregnancy. In this review, we will discuss the immunological impacts of hCG during pregnancy and if this hormone might be used therapeutically.

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“…Four of them showed antibodies, but the neutralizing effect of hCG could be counter passed by increasing the doses of hCG used (75). The same kind of antibodies were described in women (77, 78). Immune response against hCG impairs fertility of women and induces pregnancy loss within the first trimester of pregnancy.…”

Section: Antibodies Modulating the Activity Of Chorionic Gonadotropinsmentioning

confidence: 99%

“…To thwart this negative effect, Muller and collaborators described a treatment that was successful in three women positive for hCG antibodies. This treatment combined membrane plasmapheresis, prednisolone, and intravenous immunoglobulin therapy (78).…”

Section: Antibodies Modulating the Activity Of Chorionic Gonadotropinsmentioning

confidence: 99%

Modulation of Gonadotropins Activity by Antibodies

Kara¹,

Dupuy²,

Bouillon

et al. 2019

Front. Endocrinol.

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Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.

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Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases

Cited by 10 publications

References 16 publications

Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

Human Chorionic Gonadotrophin: New Pleiotropic Functions for an “Old” Hormone During Pregnancy

Modulation of Gonadotropins Activity by Antibodies

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