Modulation of Gonadotropins Activity by Antibodies

Abstract

Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.

Nanotechnology and Reproductive Management of Farm Animals: Challenges and Advances

“…First, through preventing the interaction of eCG with its receptors; second, by a conformational change in eCG by anti-eCG antibodies, which can inhibit eCG bioactivities. It is worth noting that these modulations of eCG bioactivities by its antibodiesmainly impact the FSH bioactivity of eCG rather than the LH bioactivity, which is essential for the recruitment and development of ovarian follicles, and therefore fertility is affected after repeated treatments [45,46]. In this context, ewes subjected up to three times to eCG/FSH based-super ovulatory treatments showed a lower fertilization rate and lower number of total recovered and viable embryos at the second and third recoveries when compared to the first flushing [44].…”

Current Status and Future Perspectives of Anti-Angiogenic Therapeutic Attempts for Glioblastoma

“…Moreover, by binding two VEGF molecules, via the two Fab domains, bevacizumab may produce a divalent ligand for NPs thus increasing the affinity of VEGF to NPs and favoring the subsequent clustering of integrins in signaling complexes. Such a potentiating effect of antibodies against the growth factor was previously described [48,49].…”

Bovine Polyclonal Anti-eCG and eCG Combinated Vaginal Sponges Progesterone to Induce Estrus and Pregnancy of Etawa Crossbred Goats

“…Developmentr of against gonadotropins movement, there's along absent until to go therapeutic anti body target can be reach the advertise [3] . The time of estrus When the device removed in general estrus response is high within 72 hr [4] .…”

“…The synchronization dairy goats have been done in France that has been success in estrus and pregnancy rates greater than 65% then the condition is continued by artificial insemination with quality cement and experienced inseminator. Strategies which use progesterone or its analogs are based on their impacts within the luteal stage of the cycle reenacting the activity of characteristic progesterone delivered by the corpus luteum after ovulation [1,2,3,4,5] . Utilize of prostaglandins is an elective strategy for controlling generation by disposing of the corpus and actuating luteum an ensuing follicular stage with ovulation (the following, however, the study distinguishes the use of progesterone ear implants from commercial intravaginal progesterone devices as a material for estrus synchronization.…”