Successful pregnancy after breast cancer therapy: dream or reality?

Kontzoglou, Konstantinos; Tsaknaki, S; Goga, Helen; Kostakis, A.; Safioleas, Michael

doi:10.1186/1477-7800-6-7

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Survival does not appear to be adversely affected by post-diagnosis pregnancy; however, this may be partially attributable to a “healthy mother effect” [ 18 , 21 , 22 ]. Few published studies have examined infant outcomes after a breast cancer diagnosis [ 8 , 18 , 20 , 23 – 25 ]. Our study examined the prevalence of PTB, LBW, and SGA according to breast cancer history (i.e., a personal breast cancer diagnosis) prior to infant delivery in a population-based study in North Carolina (NC), and evaluated potential effect modification by race.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of preterm, low birthweight, and small for gestational age delivery after breast cancer diagnosis: a population-based study

et al. 2017

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BackgroundBlack-white disparities in breast cancer incidence rates and birth outcomes raise concerns about potential disparities in the reproductive health of premenopausal breast cancer survivors. We examined the prevalence of preterm birth (PTB), low birthweight (LBW), and small for gestational age (SGA) by breast cancer history and effect modification by race.MethodsWe analyzed linked North Carolina birth records and Central Cancer Registry files from 1990 to 2009 (n = 2,325,229). We used multivariable negative log-binomial regression to calculate prevalence ratios (PRs) and 95% confidence intervals (CIs) for the association between breast cancer history and PTB, LBW, and SGA.ResultsOf 1,912,269 eligible births, 512 births were to mothers with a previous breast cancer diagnosis history. Average age at breast cancer diagnosis was 31.8 years (SD = 4.7). Mean time from diagnosis to delivery was 3.3 years (SD = 2.8). After multivariable adjustment, the PR was 1.67 (95% CI, 1.42–1.97) for PTB, 1.50 (95% CI, 1.23–1.84) for LBW, and 1.30 (95% CI, 1.05–1.61) for SGA comparing women with a breast cancer history to the general population. Among black mothers, the PRs associated with breast cancer history for PTB, LBW, and SGA were 1.31 (95% CI, 1.00–1.72), 1.49 (95% CI, 1.14–1.94), and 1.44 (95% CI, 1.11–1.87), respectively. The corresponding PRs among white mothers were 2.06 (95% CI, 1.67–2.54), 1.53 (95% CI, 1.12–2.08), and 1.10 (95% CI, 0.77–1.58), respectively. The interaction between breast cancer history and race was statistically significant for associations with PTB, but not for LBW or SGA.ConclusionsIn our data, women with a breast cancer history were at higher risk of delivering a PTB, LBW, or SGA infant, especially if they received chemotherapy or gave birth within 2 years of their breast cancer diagnosis date.

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Section: Introductionmentioning

confidence: 99%

Prevalence of preterm, low birthweight, and small for gestational age delivery after breast cancer diagnosis: a population-based study

et al. 2017

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“…3,29 Não está ainda inequivocamente demonstrado que os filhos de mulheres cuja gestação ocorreu após o tratamento para o cancro da mama estejam sujeitos a riscos aumentados no que respeita à sua saúde e alguns estudos epidemiológicos prospetivos observacionais parecem confirmar a ausência de risco. 1,40,41 Não foi evidenciado qualquer aumento do número de recém-nascidos prematuros, recém-nascidos de baixo peso, anomalias congénitas fetais ou morte neonatal.…”

Section: Impacto Da Gravidez Após Tratamento Do Cancro Da Mama: No Fetounclassified

Gravidez após o Cancro da Mama: Estado da Arte

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Figueiredo-Dias

2017

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RESUMOAs sobreviventes de cancro da mama têm originado um conjunto de questões da maior relevância sob o ponto de vista clínico e cientí-fico. De facto, o cancro da mama é a neoplasia mais prevalente em mulheres em idade reprodutiva. O efeito da gravidez na sobrevida global e na recorrência após tratamento de cancro da mama, bem como as questões relacionadas com a hereditariedade continuam a ser matéria da maior atualidade e do mais elevado interesse científico. Os estudos mais recentes são consensuais em admitir que a gravidez após o cancro da mama é potencialmente segura para a doente e sua descendência, embora a questão permaneça complexa. A hereditariedade e a genética parecem desempenhar um papel importante nesta temática mas, também aqui, as conclusões carecem de absoluta e inequívoca consistência. Verifica-se a necessidade de meta-análises, estudos coorte e caso-controlo, translacionais e prospetivos, alargados e prolongados no tempo, no sentido de obter uma maior segurança no estabelecimento de estratégias e linhas de orientação para os clínicos e informação adequada e objetiva para as jovens doentes com cancro da mama. Palavras-chave: Complicações Neoplásicas na Gravidez; Gravidez; Neoplasias da Mama ABSTRACTBreast cancer survivors have given rise to several issues of major relevance from a clinical and scientific point of view. In fact, breast cancer is the most prevalent malignancy in women of reproductive age. The effect of pregnancy on overall survival and in the recurrence after treatment of breast cancer, as well as the questions related to heredity continue to be matter of the highest timeliness and scientific interest. Most recent studies seem to agree in admitting that pregnancy after breast cancer appears to be potentially safe to both the women and her offspring, although this issue remains complex. Heredity and genetics seem to play an important role in this subject, but the conclusions lack absolute and unequivocal consistency. There is a need for meta-analysis, cohort and case-control studies, translational and prospective studies extended in time, in order to obtain greater safety in the establishment of strategies and guidelines for clinicians and adequate objective information for young breast cancer patients. Keywords: Breast Neoplasms; Pregnancy; Pregnancy Complications, Neoplastic INTRODUÇÃOO cancro da mama em mulheres jovens representa um cenário particularmente complexo; na verdade, apesar de mais prevalente na mulher pós-menopausa, o cancro da mama constitui a neoplasia mais comum na mulher em idade reprodutiva, correspondendo a cerca de 40% de todos os cancros em mulheres com idades inferiores a 40 anos. 1-3Dada a presente tendência em adiar a maternidade, muitas mulheres são diagnosticadas com cancro da mama antes de engravidar, sendo mais comum a intenção de engravidar após a doença. 4O diagnóstico desta neoplasia em idade reprodutiva poderá ter grande impacto no projeto familiar destas mulheres, dada a necessidade consequente de adiar a maternidade. 1,5,6 As sobreviventes de c...

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