Successful outcome of a surgically treated giant retroperitoneal liposarcoma during pregnancy

Lopes, Roberto Iglesias; Machado, Maria Aparecida Miranda de Paula; Paz, Carla; Santos, Antonio Carlos; Rezende, Waldemir Washington

doi:10.1007/s00404-009-1061-9

Cited by 12 publications

(20 citation statements)

References 7 publications

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“…Liposarcoma is one of the most common soft-tissue sarcomas that frequently occur between the ages of 40 to 70 years [1,2]. Usually it is located at lower extremities and the retroperitoneum.…”

Section: Discussionmentioning

confidence: 99%

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A case of huge retroperitoneal liposarcoma in pregnancy

Kim

Choi

et al. 2014

Obstet Gynecol Sci

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A 39-year-old woman was referred to our hospital at 28+2 week gestation. Routine obstetric examination revealed a palpable pelvic mass. Initial investigation by magnetic resonance imaging demonstrated a huge solid mass with heterogeneous enhancement that completely filled the right side of the abdomen. She underwent two surgeries: a programmed cesarean section by Department of Obstetrics and Gynecology team and a laparotomy performed by the General Surgery team. Final diagnosis was de-differentiated liposarcoma (French Federation Nationale des Centres de Lutte Contre le Cancer grade 2/3). She has been treated with radiation therapy focusing on high risk area of retroperitoneum followed by adjuvant chemotherapy (doxorubicin and ifosfamide). Below is the full case with literature review.

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Section: Discussionmentioning

confidence: 99%

“…Liposarcoma is one of the most common soft-tissue sarcomas occurring in adults between 40 and 70 years [1,2]. According to the World Health Organization (WHO), histological classification of liposarcoma is divided into five subtypes: well-differentiated, myxoid, round cell, pleomorphic, and de-differentiated [3].…”

Section: Introductionmentioning

confidence: 99%

A case of huge retroperitoneal liposarcoma in pregnancy

Kim

Choi

et al. 2014

Obstet Gynecol Sci

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“…Most patients present with an abdominal mass, and in almost half, vague abdominal pain may be the only presentation. As in our case, the location of the tumour may allow it to attain a considerable size before diagnosis, because of almost unrestricted potential for growth and of relative mobility of the anterior intra-abdominal organs 19 . Correlation of imaging findings with histologic subtype has been attempted, with the ct patterns varying depending on the amount and distribution of adipose and nonadipose tissue in the tumour.…”

Section: Figure 2 (A) Photomicrograph Of the Gastrectomy Specimen Shomentioning

confidence: 99%

Rare Synchronous Primary Large B-cell Gastric Lymphoma and Huge Retroperitoneal Liposarcoma with Inguinal Hernia in Chronic Hepatitis B Patient

Ghimire

Zhu

2011

Current Oncology

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pain. During the most recent 2 months, his symptoms had been persistent and increasingly severe. He had noticed progressive distension of the abdomen, with swelling in the right inguinal region and scrotum. The patient had been diagnosed with hepatitis B in 1976, which had been treated with the antiviral agent lamivudine for 1 year in 1996 and which was not subsequently followed up.Physical examination of the abdomen revealed a firm, non-tender mass occupying almost all of the abdomen. The inguinal region demonstrated a complete indirect inguinal hernia with cystic consistency. The markers for chronic hepatitis B virus (hbv) were positive, including hepatitis B surface antigen, antihepatitis B e-antibody, and anti-hepatitis B core antibody, with a hbv dna level of 7.56×10 3 copies per millilitre. Liver function tests and a hematologic profile were within normal limits.Esophagogastroduodenoscopy demonstrated a deformed antrum, with a deep ulcer (approximately 4 cm, with an irregular margin) at the lesser curvature and a few bleeding points. Histopathology of an endoscopic biopsy specimen of the lesion was inconclusive. Biopsy material was negative for Helicobacter pylori. Computed tomography (ct) imaging of the whole abdomen revealed marked circumferential gastric antral wall thickening, with a lobulated inner surface and a smooth well-defined outer wall [ Figure 1(A)]. After intravenous contrast, the thickened wall showed minimal homogeneous enhancement, with preservation of the perigastric fat plane [Figure 1(B)]. Few perigastric lymph nodes were noted. A huge, well-defined heterogeneous abdominal mass measuring 26×12×26 cm with predominant fat attenuation and no calcification occupied the retroperitoneum, extending from the infrapancreatic level to the pelvis. This tumour also had thickened, irregular septa with nodular components whose attenuation approximated that of skeletal muscle [ Figure 1(C)]. The mass displaced the bowel loops laterally and superiorly. Post-contrast imaging showed moderate enhancement of the septa of the retroperitoneal mass ABSTRACTMultiple primary neoplasms with synchronous or metachronous presentation are rare, although the incidence has recently increased because of several factors. We present the case of a 53-year-old patient with chronic hepatitis B who presented with abdominal mass, mild abdominal pain, and inguinal hernia. Computed tomography imaging demonstrated diffuse thickening of the gastric antral wall, together with a huge heterogeneous abdominal mass with predominant fat attenuation with septa that showed mild enhancement on contrast-enhanced scans. Distal gastrectomy and wide resection of the retroperitoneal mass was performed. Pathology exam led to a diagnosis of diffuse large B-cell gastric lymphoma with retroperitoneal liposarcoma. This is a rare case of a primary gastric lymphoma with another primary (sarcomatous) malignancy occurring synchronously in same patient.

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“…The World Health Organization classified liposarcomas into well-differentiated, myxoid, round-cell, pleomorphic and dedifferentiated subtypes; the first two subtypes belong to the low-grade lesions with better prognosis and higher incidence rates, which largely depends on the histologic subtypes, resection margin and age of the patients. 1,2 With free surgical margin, the 5-year overall survival rate can be 68-80%, although the local recurrence rate 75%. 2,3 The peak prevalence of retroperitoneal liposarcoma (RPLS) is between the age of 40 to 70 years, usually seen in male 1.43:1.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 With free surgical margin, the 5-year overall survival rate can be 68-80%, although the local recurrence rate 75%. 2,3 The peak prevalence of retroperitoneal liposarcoma (RPLS) is between the age of 40 to 70 years, usually seen in male 1.43:1. Liposarcoma in pregnancy is rare but deserves practitioners' attention, for early detection and proper surgical management could greatly improve disease outcomes.…”

Section: Introductionmentioning

confidence: 99%

Giant retroperitoneal liposarcoma during pregnancy: case report

Paul

Garg

2018

Int J Reprod Contracept Obstet Gynecol

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24-year-old woman was presented with huge vulval mass for which she was operated, histopathological report of that mass shows angiomyoma. After few months she was discovered to have a giant retroperitoneal tumor incidentally during her routine obstetric examination at 24 weeks of gestation. Initial investigation by abdominal-pelvic computed tomography (CT) (18/08/18) revealed an a large multiseptated soft tissue attenuated minimally enhancing pelvic mass (31.8cmx13.2x 24cm) protruding in the abdominal cavity displacing the bowel loops proximally and pushing retro organs posteriorly. She underwent laparotomy with preservation of the fetus at 24 weeks of gestation. Final diagnosis was made after HPE report which shows myxoid liposarcoma. She was referred to regional cancer hospital for radiotherapy and then patient lost in follow up.

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Successful outcome of a surgically treated giant retroperitoneal liposarcoma during pregnancy

Abstract: Individualized approach should be taken according to gestational phase, tumor kinetics and overall patient's condition. Any disturbance to materno-fetal equilibrium, should be an indication for urgent therapeutic approach.

Cited by 12 publications

References 7 publications

A case of huge retroperitoneal liposarcoma in pregnancy

A case of huge retroperitoneal liposarcoma in pregnancy

Rare Synchronous Primary Large B-cell Gastric Lymphoma and Huge Retroperitoneal Liposarcoma with Inguinal Hernia in Chronic Hepatitis B Patient

Giant retroperitoneal liposarcoma during pregnancy: case report

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