Successful Organ Transplantation from Donors Poisoned with a Carbamate Insecticide

Garcia, José Huygens Parente; Coelho, Gustavo; Marques, G. A.; Gadelha, J. B.; Vasconcelos, J.B.M.; Valença, José Telmo; Esmeraldo, Ronaldo M.; Meija, J. A.; Leite, Christiane Araujo Chaves; Almeida, Érika Rodrigues de

doi:10.1111/j.1600-6143.2010.03132.x

Cited by 10 publications

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References 7 publications

(6 reference statements)

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“…[ 11 ] Studies have shown that victims of organophosphorus and carbamates poisoning have been overlooked as organs donors; these victims can turn out to be successful organ donors. [ 12 13 14 ]…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of corneal tissue harvested from organophosphorous deceased patients

Sarangi

Sahu

Priyadarshini

et al. 2021

Indian Journal of Ophthalmology

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Purpose: To analyze the quality of tissues and outcome of corneal transplants from tissues harvested from the donors of organophosphorus poisoning victims. Methods: A retrospective study was carried out on corneas harvested from organophosphorus poisoning victims between January 2016 and December 2018. Details of quality of tissues and outcome following keratoplasty were collected from the eye bank and outpatient records, respectively. Results: Four hundred and seventy-eight donor corneas were collected from the victims of organophosphorus poisoning during the study period. The mean age of the donor was 38.8 ± 16.5 years. The mean donor-to-preservation time was 6.2 ± 3.2 hours. The mean endothelial cell density on specular microscopy was 2986.5 ± 369.0 cells/mm 2 . Four hundred and twenty-two (88.2%) donor corneas were utilized. Of the 121 corneas utilized at our institute for transplantation, 73 and 48 corneas were for optical and therapeutic/tectonic indications, respectively. Of the 73 optical grafts, 25 patients were lost-to-follow-up and 58.3% (28/48) who came for one-year follow-up were found to be clear. Conclusion: Donor corneas retrieved from organophosphorus poisoning are safe for transplantation. The postoperative outcome of the tissue utilized from these donors is satisfactory.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of corneal tissue harvested from organophosphorous deceased patients

Sarangi

Sahu

Priyadarshini

et al. 2021

Indian Journal of Ophthalmology

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“…Data regarding organ donation after pesticide poisoning are scant [3,4]. Successful liver, kidney, and even heart donation has been reported after carbamate poisoning [3,4]. Carbamate compounds are reversible cholinesterase inhibitors undergoing rapid urinary excretion.…”

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confidence: 99%

Organ donation following fatal organophosphate poisoning

Mariage

Gallinat

Hantson

2012

Transplant International

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Poisoned donors are often overlooked as organ donors because of the perceived risks of toxins transmission or organ dysfunction [1,2]. We describe a case of successful liver and kidneys donation after fatal organophosphate (OP) poisoning.A 49-year-old man was admitted to the hospital after the suicidal ingestion of an unknown amount of the OP compound parathion (E-605 from Bayer Ò , Leverkusen, Germany), a pesticide that has been officially banned for many years. He had a medical history of chronic ethanol abuse and grade I chronic obstructive pulmonary disease. He had been found in cardiac arrest with no bystander rescue. After cardiac massage (10 min), intubation for mechanical ventilation, and 10 mg of i.v. atropine, there was a rapid return of spontaneous ventilation before arrival at the hospital.The patient was hemodynamically stable, but remained comatose with pinpoint pupils and myoclonus. Laboratory results revealed an ethanol blood concentration of 3.39 g/l, with a marked decrease of serum cholinesterase (386 IU/l, normal values 5860-13 060) consistent with the diagnosis of severe OP poisoning. The patient received a total dose of 27 500 mg of pralidoxime and 410 mg of atropine during the first 6 days. The treatment was pursued for persisting miosis, fasciculation, and decreased serum cholinesterase level (240 IU/l on day 7). The neurological condition never improved. The brain computed tomodensitometry (CT) was normal and the electroencephalogram showed diffuse slowing with theta waves. The patient suffered numerous lung complications, with atelectasis and pneumonia.On day 21, he abruptly developed hypotension and diabetes insipidus. The clinical diagnosis of brain death was confirmed by an isoelectric EEG and by the absence of intracerebral perfusion at brain angio-CT. The cause of brain death was very likely the progression of postanoxic encephalopathy, with a long initial delay between asystole and resuscitation. Organ donation was accepted by the relatives and the kidneys and the liver were recovered. The last laboratory values were: serum creatinine 0.53 mg/dl (nl < 1.69), ASAT 79 IU/l (nl < 30), ALAT 89 IU/l (nl < 35). The electrocardiogram (EKG) showed sinus rhythm with a QTc interval at 459 ms and diffuse repolarization changes.

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Poisoning Fatalities

Hantson¹

2017

Critical Care Toxicology

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Successful Organ Transplantation from Donors Poisoned with a Carbamate Insecticide

Cited by 10 publications

References 7 publications

Safety and efficacy of corneal tissue harvested from organophosphorous deceased patients

Safety and efficacy of corneal tissue harvested from organophosphorous deceased patients

Organ donation following fatal organophosphate poisoning

Poisoning Fatalities

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