Successful Liver and Kidney Transplantation From Cadaveric Donors With Left-Sided Bacterial Endocarditis

Caballero, Francisco; López-Navidad, A; Perea, Milagrosa; Cabrer, C; Guirado, Lluís; Solá, Ricard

doi:10.1111/j.1600-6143.2005.00773.x

Cited by 33 publications

(26 citation statements)

References 29 publications

(45 reference statements)

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“…Multiple retrospective studies have demonstrated the safety of transplanting livers that were procured from donors with bacterial infections (96). Organs have been successfully transplanted from donors with Gram-positive endocarditis and bacteremia with no effect on 1-year survival (293,294). Liver transplantation has also been successful utilizing grafts from donors with active meningitis (105).…”

Section: Recommendationsmentioning

confidence: 98%

Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

269

150

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This document was developed through the collaborative efforts of the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations. Under the auspices of these societies, a multidisciplinary, multi-institutional task force was convened, incorporating expertise in critical care medicine, organ donor management, and transplantation. Members of the task force were divided into 13 subcommittees, each focused on one of the following general or organ-specific areas: death determination using neurologic criteria, donation after circulatory death determination, authorization process, general contraindications to donation, hemodynamic management, endocrine dysfunction and hormone replacement therapy, pediatric donor management, cardiac donation, lung donation, liver donation, kidney donation, small bowel donation, and pancreas donation. Subcommittees were charged with generating a series of management-related questions related to their topic. For each question, subcommittees provided a summary of relevant literature and specific recommendations. The specific recommendations were approved by all members of the task force and then assembled into a complete document. Because the available literature was overwhelmingly comprised of observational studies and case series, representing low-quality evidence, a decision was made that the document would assume the form of a consensus statement rather than a formally graded guideline. The goal of this document is to provide critical care practitioners with essential information and practical recommendations related to management of the potential organ donor, based on the available literature and expert consensus.

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Section: Recommendationsmentioning

confidence: 98%

Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

269

150

View full text Add to dashboard Cite

show abstract

“…Furthermore, a recent report showed few cases of successful transplantation of donor organs (liver and kidney) retrieved from donors with left-sided bacterial endocarditis [40]. The role of donor related pneumonia especially in lung and heartlung transplantation seems to be less important.…”

Section: Patientmentioning

confidence: 97%

Impact of Bacterial and Fungal Donor Organ Contamination in Lung, Heart–Lung, Heart and Liver Transplantation

et al. 2008

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We investigated to which extent bacterial and fungal donor organ contamination (DOC) caused posttransplant nosocomial infections (NI) in solid organ transplant (Tx) recipients. Between January 2002 to December 2003 (lung and heart Tx) and October 2003 to September 2004 (liver Tx), NIs were determined according to modified CDC criteria for NIs for all transplantations performed at Hannover Medical School. Organisms of the same species cultured from donor organs and infected transplantees were genotyped if available. Out of 282 solid organ recipients (140 lung-Tx, 16 heart-lung-Tx, 51 heart-Tx, 75 liver-Tx), 150 recipients (53.2%) received contaminated donor organs. Incidences of NIs were 33.7% in lung, 68.8% in heart-lung, 21.6% in heart, and 28% in liver recipients. In 11 out of 282 transplantees (3.9%, CI (95%) 2.0-6.9%) organisms of NIs and of contamination of the donor organ were of the same species. Even if assuming five missing pairs of organisms as genetically identical, incidences of DOC-related posttransplant infections were only between 1.3% (CI(95%) 0.0; 7.2) in liver-Tx and 18.8% (CI(95%) 4; 45.6) in heart-lung Tx, and DOC related mortality was 0.4% (CI(95%) 0.0;1.9). Despite high DOC rates, posttransplant infections due to DOC were rare under the condition of adequate preoperative antibiotic prophylaxis and aseptic organ retrievement.

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“…Kidney and liver transplants were made from these donors with cultureguided antibiotic therapy, with no recipient infectionrelated complications (C). (82) Similarly, a donor who died from Naegleria fowleri amoebic meningoencephalitis had kidneys, the pancreas, one lung and the liver transplanted, with no recipient infectious complications (C). (83) Also, Zibari et al published their experience with 599 donors with positive blood cultures (7.5% of the cases) and urine cultures (4.5% of the cases).…”

Section: Infection Aspectsmentioning

confidence: 99%