Successful Live Kidney Transplantation After Chikungunya Disease in the Donor

Moura-Neto, José A.; Moura, Ana Flávia; Souza, Edison; Henriques, Jodélia L. M.; Arruda, Mónica; Pessôa, Luciana Fontes; Boullosa, Lídia Theodoro; Ferreira, Orlando da Costa; Suassuna, José Hermógenes Rocco

doi:10.1016/j.ekir.2017.06.003

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…77 On the other hand, transplantation appears to be safe to the receiver from donors with recent infection in which the symptoms have been resolved and a negative serology achieved. 66 CHIKV infection does not seem to be related to a poor renal outcome or a higher prevalence of chronic manifestations in solid organ transplant recipients. Eventually these patients may experience transient renal dysfunction, but without apparent graft damage.…”

Section: Discussionmentioning

confidence: 85%

The relationship between chikungunya virus and the kidneys: A scoping review

Costa

Gouveia

Silva

et al. 2022

Reviews in Medical Virology

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Several atypical forms of chikungunya fever (CHIK) have been described, including neurological, cardiac and renal involvement. These forms may be related to high morbidity and mortality rates. This scoping review based on the PubMed, Scopus, and WOS databases aims to identify and summarise all the available evidence regarding the clinical and histopathological presentations and risk factors associated with kidney injury related to CHIK, as well as the clinical impact. Thus, a total of 54 papers were selected from 1606 initial references after applying the defined inclusion criteria. Data on the association between kidney injury and CHIK are scarce, with studies only conducted in the acute phase of the disease, lacking further characterisation. Kidney injury incidence in hospitalised patients using the Kidney Disease Improving Global Outcomes criteria varies from 21% to 45%, being higher among patients with atypical and severe manifestations. Although acute kidney injury does not seem to be related to viraemia, it may be related to higher mortality.Few studies have described the renal histopathological changes in the acute phase of CHIK, with prevalent findings of acute interstitial nephritis with mononuclear infiltrate, glomerular congestion and nephrosclerosis. Only one study assessed the kidney function of patients in the subacute and chronic phases of CHIK. Additionally, individuals with comorbidities, including chronic kidney disease, may be among those with a greater risk of presenting worse outcomes when affected by CHIK. The results described herein may contribute to better understand the relationship between the kidneys and chikungunya virus.

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Section: Discussionmentioning

confidence: 85%

The relationship between chikungunya virus and the kidneys: A scoping review

Costa

Gouveia

Silva

et al. 2022

Reviews in Medical Virology

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“…The kidneys are one of the most common organs to be transplanted, which presents an interesting concern for CHIKV infection [103]. In addition to acquiring CHIKV via a mosquito bite after transplantation, it is possible for an organ recipient to become infected from a CHIKV-positive donor [104,105]. Transplantation can be deferred until the donor has cleared the infection [105].…”

Section: Potential Renal Complications and Concerns For Organ Transpl...mentioning

confidence: 99%

Chikungunya Immunopathology as It Presents in Different Organ Systems

Traverse

Millsapps

Underwood

et al. 2022

Viruses

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Chikungunya virus (CHIKV) is currently an urgent public health problem as high morbidity from the virus leaves populations with negative physical, social, and economic impacts. CHIKV has the potential to affect every organ of an individual, leaving patients with lifelong impairments which negatively affect their quality of life. In this review, we show the importance of CHIKV in research and public health by demonstrating the immunopathology of CHIKV as it presents in different organ systems. Papers used in this review were found on PubMed, using “chikungunya and [relevant organ system]”. There is a significant inflammatory response during CHIKV infection which affects several organ systems, such as the brain, heart, lungs, kidneys, skin, and joints, and the immune response to CHIKV in each organ system is unique. Whilst there is clinical evidence to suggest that serious complications can occur, there is ultimately a lack of understanding of how CHIKV can affect different organ systems. It is important for clinicians to understand the risks to their patients.

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“…75 It is recommended not to accept donors until 30 days after the symptoms end. 76 YF is considered one of the most severe arboviral infections and is associated with high mortality rates, independent of the baseline patient characteristics. There are two epidemiological cycles of YF disease: wild and urban.…”

Section: Peculiarities Of the Most Frequent Tropical Infections In Kidney Transplant Patientsmentioning

confidence: 99%

Tropical Infections in the Context of Kidney Transplantation in Latin America

Requião-Moura

Daher

Albino

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Reports on tropical infections among kidney transplant (KT) recipients have increased in recent years, mainly because of the growing number of KT programs located in tropical and subtropical areas, and greater mobility or migration between different areas of the world. Endemic in emerging and developing regions, like most countries in Latin America, tropical infections are an important cause of morbidity and mortality in this population. Tropical infections in KT recipients may exhibit different pathways for acquisition compared with those in nonrecipients, such as transmission through a graft and reactivation of a latent infection triggered by immunosuppression. Clinical presentation may differ compared with that in immunocompetent patients, and there are also particularities in diagnostic aspects, treatment, and prognosis. KT patients must be screened for latent infections and immunized properly. Last, drug–drug interactions between immunosuppressive agents and drugs used to treat tropical infections are an additional challenge in KT patients. In this review, we summarize the management of tropical infections in KT patients.

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Successful Live Kidney Transplantation After Chikungunya Disease in the Donor

Cited by 7 publications

References 19 publications

The relationship between chikungunya virus and the kidneys: A scoping review

The relationship between chikungunya virus and the kidneys: A scoping review

Chikungunya Immunopathology as It Presents in Different Organ Systems

Tropical Infections in the Context of Kidney Transplantation in Latin America

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