Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

Sfakianoudis, Konstantinos; Simopoulou, Mara; Nitsos, Nikolaos; Lazaros, Leandros; Rapani, Anna; Pantou, Agni; Koutsilieris, Michael; Nikas, Yorgos; Pantos, Konstantinos

doi:10.21873/invivo.11504

Cited by 47 publications

(25 citation statements)

References 46 publications

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“…Concerning the field of reproductive medicine, PRP treatment was clinically performed with an emphasis on improving endometrial growth, and pregnancy outcome following IVF [ 27 , 28 ]. Moreover, endometrial PRP infusion was reported for managing chronic endometritis, resulting in live birth [ 29 ]. The radical concept of autologous intraovarian PRP ovaries infusion was pioneered [ 30 , 31 ], with the intent to revive ovarian function in perimenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Sfakianoudis¹,

Simopoulou

Grigoriadis

et al. 2020

JCM

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Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency.

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Section: Introductionmentioning

confidence: 99%

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Sfakianoudis¹,

Simopoulou

Grigoriadis

et al. 2020

JCM

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“…Pregnancies were also reported (21,28). The impact of PRP in treating human reproductive disorders is also reported in some papers describing its positive effect after intrauterine administration in patients with repeated implantation failure (28) and chronic endometritis (29).…”

Section: Discussionmentioning

confidence: 93%

Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction

Crémonesi

Bonfanti²,

Idda

et al. 2020

Front. Vet. Sci.

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Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in growth factors, chemokines, and cytokines that could stimulate follicular growth and steroidogenesis. Twelve cows with ovarian hypofunction were enrolled in the study and they were randomly allocated in control group (CTR) and treated group (six animal for group). In the treated group, only five animals received the PRP treatment because intraovarian administration was hindered in one by a rectovaginal fistula. Animals of control group were treated by intraovarian administration of physiological solution. In the 4 weeks after PRP injection, a mild to strong increase in progesterone (PRG) concentrations was detected in four of the five cows treated. Artificial insemination (AI) resulted in four pregnancies that are still ongoing (7th month). Intraovarian administration of PRP improved ovarian function after 2 months of treatment. This effect may be due to reduction of follicular atresia or to revitalization of dormant oocytes allowing restoration of fertility.

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“…After a review of the titles and abstracts, 154 studies were identified as potentially eligible for inclusion. After a full review, we excluded 19 systematic reviews or meta-analysis 2,5,22,23,37,[46][47][48][49][50][51][52][53][54][55][56][57][58][59] , 8 case reports [60][61][62][63][64][65][66][67] , 4 letters to the editor [68][69][70][71] and 81 original studies [references and reasons for exclusion are reported in Table 1]. Data on the efficacy of therapies and interventions for RIF were extracted from the remaining 42 articles 8,12,13,18,20,21,24,27,28,31,75, .…”

Section: Resultsmentioning

confidence: 99%

Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis

Busnelli

Somigliana

Cirillo

et al. 2021

Sci Rep

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The aim of the present systematic review and meta-analysis was to assess the effect of the different therapeutic options for repeated embryo implantation failure (RIF) on a subsequent IVF cycle outcome. Twenty-two RCTs and nineteen observational studies were included. Pooling of results showed a beneficial effect of intrauterine PBMC infusion on both CPR (RR 2.18; 95% CI 1.58–3.00; p < 0.00001; OR 2.03; 95% CI 1.22–3.36; p = 0.006) and LBR (RR 2.41; 95% CI 1.40–4.16; p = 0.002; OR 3.73; 95% CI 1.13–12.29; p = 0.03), of subcutaneous G-CSF administration on CPR (RR 2.29; 95% CI 1.58–3.31; p < 0.0001) and of intrauterine PRP infusion on CPR (RR 2.45; 95% CI 1.55–3.86; p = 0.0001). Observational studies also demonstrated a positive effect of IVIG and intrauterine hCG infusion on both CPR and LBR and of atosiban on CPR. Studies investigating intrauterine G-CSF infusion, LMWH, intravenous intralipid, hysteroscopy, blastocyst-stage ET, ZIFT, PGT-A and AH failed to observe an impact on IVF outcome. The quality of the evidence that emerged from RCTs focused on intrauterine PBMC infusion and subcutaneous G-CSF administration was moderate. For all other therapies/interventions it varied from low to very low. In conclusion, intrauterine PBMC infusion and subcutaneous G-CSF administration are the most promising therapeutic options for RIF. However, further well conducted RCTs are necessary before their introduction into clinical practice.

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Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

Cited by 47 publications

References 46 publications

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction

Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis

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