2014
DOI: 10.1089/lap.2013.0418
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Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System

Abstract: The results of the present report indicate that FGS using a fluorophore-conjugated anti-CEA antibody and portable imaging system improves efficacy of resection for CEA-positive colorectal cancer. These data provide the basis for clinical trials.

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Cited by 123 publications
(93 citation statements)
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“…The cumulative effects of PEGylation were to increase dye-conjugated anti-CEA antibody half-life, favorably alter the biodistribution, and significantly increase tumor to background contrast. PEGylated dyes conjugated to tumor-specific antibodies should have an important impact in the development of fluorescence guided surgery of cancer, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] as these dyes offer the possibility of high fidelity-targeted tumor and metastases labeling.…”
Section: Tissue Biodistributionmentioning
confidence: 99%
“…The cumulative effects of PEGylation were to increase dye-conjugated anti-CEA antibody half-life, favorably alter the biodistribution, and significantly increase tumor to background contrast. PEGylated dyes conjugated to tumor-specific antibodies should have an important impact in the development of fluorescence guided surgery of cancer, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] as these dyes offer the possibility of high fidelity-targeted tumor and metastases labeling.…”
Section: Tissue Biodistributionmentioning
confidence: 99%
“…Toward the goal of precision oncology, our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI), including pancreatic, [1][2][3][4] breast, 5 ovarian, 6 lung, 7 cervical, 8 colon, [9][10][11] and stomach cancer, 12 sarcoma, [13][14][15][16][17] and melanoma. [18][19][20] In a previous study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared with cisplatinum (CDDP) on a lung-metastatic osteosarcoma PDOX mouse model.…”
Section: Introductionmentioning
confidence: 99%
“…PDOX models, which were implanted using intact tumor tissue with the technique of surgical orthotopic implantation (SOI) (25,27), were established from patients with colonic (28)(29)(30), pancreatic (21, 31-41), breast (42), ovarian (43), lung (44), and stomach cancer (45), and mesothelioma (46) in the early 1990s, resulting in primary and metastatic tumor growth very similar to that in the patient.…”
Section: Patient-derived Orthotopic Xenograft (Pdox) Mouse Models Of mentioning
confidence: 99%