Successful en bloc resection of primary hepatocellular carcinoma directly invading the stomach and pancreas

Korkolis, Dimitris P.; Aggeli, Chrysanthi; Plataniotis, George D.; Gontikakis, Emmanuel; Zerbinis, Helen; Papantoniou, Nikitas; Xinopoulos, Dimitrios; Apostolikas, N.; Vassilopoulos, P.

doi:10.3748/wjg.15.1134

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…Hepatectomy with gastrectomy or duodenectomy was not frequent, supporting previous reports (8,28,29). Many patients showed direct invasion of liver malignancy to the adjacent stomach or duodenum, so limited resection of these organs was selected.…”

Section: Casesupporting

confidence: 52%

“…Many patients showed direct invasion of liver malignancy to the adjacent stomach or duodenum, so limited resection of these organs was selected. En bloc resection might be significant use according to a previous study (8). In cases of gastric carcinoma, simultaneous hepatectomy for liver metastasis must not be selected because of poor prognosis (30).…”

Section: Casementioning

confidence: 99%

“…In case of hepatectomy for patients with malignancy or concomitant diseases, hepatectomy combined with resection of other organs is often necessary, including tissues such as diaphragm, lung, adrenal gland, and spleen (3)(4)(5)(6)(7)(8)(9). Surgeons may carefully decide the operative indications for simultaneous multi-organ resections and may select patients with better functional organ reserve, including liver functions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Safety of Hepatectomy Accompanying Combined Resection of Other Organs

Nanashima¹,

Abo²,

Takeshita³

et al. 2011

HGE

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Section: Casesupporting

confidence: 52%

Section: Casementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety of Hepatectomy Accompanying Combined Resection of Other Organs

Nanashima¹,

Abo²,

Takeshita³

et al. 2011

HGE

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show abstract

“…Up to 65% of HCC patients also present extrahepatic metastasis at autopsy[ 7 - 9 ]. HCC can also metastasize to stomach via direct invasion[ 10 ]. Detachment from the tumor mass and invasion of the extracellular matrix and the basement membrane are important steps in tumor cell invasion and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1

Gui

Khan

Bobbala

et al. 2017

WJG

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AIMTo investigate the role of suppressor of cytokine signaling 1 (SOCS1) in regulating MET-mediated invasive potential of hepatocellular carcinoma (HCC) cells.METHODSStable derivatives of mouse (Hepa1-6) and human (hep3B, HepG2) HCC cell lines expressing SOCS1 or control vector were evaluated for their ability to migrate towards hepatocyte growth factor (HGF) in the transwell migration assay, invade extracellular matrix in response to HGF stimulation in a 3-D invasion assay by confocal microscopy, and to undergo anchorage-independent proliferation in semisolid agar. Following intravenous and intrasplenic inoculation into NOD.scid.gamma mice, the ability of Hepa cells to form othotopic tumors was evaluated. Following HGF stimulation of Hepa and Hep3B cells, expression of proteins implicated in epithelial-to-mesenchymal transition was evaluated by western blot and qRT-PCR.RESULTSSOCS1 expression in mouse and human HCC cells inhibited HGF-induced migration through matrigel. In the 3-D invasion assay, HGF stimulation induced invasion of HCC cells across type-I collagen matrix, and SOCS1 expression significantly reduced the depth of invasion. SOCS1 expression also reduced the number and size of colonies formed by anchorage-independent growth in semisolid agar. Following intravenous inoculation, control Hepa cell formed large tumor nodules that obliterated the liver whereas the SOCS1-expressing Hepa cells formed significantly smaller nodules. Tumors formed by SOCS1-expressing cells showed reduced phosphorylation of STAT3 and ERK that was accompanied by reduced levels of MET protein expression. HGF stimulated Hepa cells expressing SOCS1 showed increased expression of E-cadherin and decreased expression of EGR1, SNAI1 and ZEB1. Comparable results were obtained with Hep3B cells. SOCS1 expressing HCC cells also showed reduced levels of EGR1 and SNAI1 transcripts.CONCLUSIONOur findings indicate that loss of SOCS1-dependent control over epithelial-to-mesenchymal transition may contribute to MET-mediated migration, invasion and metastatic growth of HCC.

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“…HCCs that are very large in size and mass develop mostly in non-cirrhotic livers (1). HCC characteristically has a soft consistency in nature and has an extensive growth pattern, but it rarely infiltrates the gastrointestinal (GI) tract directly (2).…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Okay

Sari²,

Odabaşoğlu³

et al. 2014

Turk J Gastroenterol

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Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is generally associated with hepatitis B or C virus-related cirrhosis. A giant intra-abdominal HCC mass that fills nearly the whole abdomen is not often reported in the literature. In this report, we present a case in which a patient with hepatitis B developed a giant intra-abdominal mass that originated from segment three of the liver and infiltrated the stomach and transverse colon. We were able to resect the tumor without leaving any tumor tissue behind. Although HCC presenting as a huge mass with invasion of the gastrointestinal tract is uncommon, this pathology should be considered in the differential diagnosis of giant intra-abdominal masses. The case presented here also indicates that surgical resection is possible in selected patients.

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Successful en bloc resection of primary hepatocellular carcinoma directly invading the stomach and pancreas

Cited by 15 publications

References 14 publications

Safety of Hepatectomy Accompanying Combined Resection of Other Organs

Safety of Hepatectomy Accompanying Combined Resection of Other Organs

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1

Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

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