Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Okay, Erdem; Sari, A; Odabaşoğlu, Hülya; Uygun, Kazım; Sarısoy, Tahsin; Gürbüz, Yeşim

doi:10.5152/tjg.2014.3255

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…direct-acting antiviral drugs questioned the impact of those drugs on the occurrence or recurrence of HCC in patients with HCV related cirrhosis. [3,[7][8][9] Such finding was not seen in other cases treated with interferon-based regimens, and this endorsed specialists to propose that those drugs may play a significant role in the development of HCC. [3,8,9] On the other hand, other studies have reported the opposite effect of direct-acting antiviral drugs on HCC occurrence or recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…[3,[7][8][9] Such finding was not seen in other cases treated with interferon-based regimens, and this endorsed specialists to propose that those drugs may play a significant role in the development of HCC. [3,8,9] On the other hand, other studies have reported the opposite effect of direct-acting antiviral drugs on HCC occurrence or recurrence. [10,11] The relationship between direct-acting antiviral agents and HCC occurrence or recurrence and the underlying possible mechanisms remain controversial and there is no enough evidence to prove or disprove this relationship.…”

Section: Introductionmentioning

confidence: 99%

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Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

Wahab¹,

Shehta

Ali³

2018

JST

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Introduction: Direct-acting antiviral drugs have been recently introduced for management of chronic hepatitis C virus (HCV) patients. Those medications have achieved a dramatic improvement of sustained virologic response (SVR) reaching almost 90%. However, reports regarding the increased risk of occurrence or recurrence of hepatocellular carcinoma (HCC) in chronic HCV patients who achieved SVR after direct-acting antiviral drugs are controversial.Methods: We report two cases of giant HCCs complicating chronic HCV infection after direct-acting antiviral drugs-based therapies and were managed by major hepatic resection.Results: Two male patients with chronic HCV infection received several regimens oral direct acting antiviral drugs with a SVR for 3 and 6 months, respectively. They complained of progressive right hypochondrial pain and abdominal enlargement. Two large HCCs were diagnosed (16.2 cm * 17.6 cm * 16.9 cm, and 18 cm * 13 cm * 16.5 cm in dimensions) with markedly elevated serum alpha feto-protein (36,000 and 7,000 ng/ml, respectively). Due to the presence of adequate residual liver volume, the decision was to proceed for surgical resection. Central hepatectomy and extended right hemi-hepatectomy were performed, respectively. Patients had smooth postoperative course and were discharged after 10 and 9 days, respectively.Conclusion: The relationship between direct-acting antiviral drugs and HCC is controversial. Those cases add support to the accumulating literature suggesting the relationship of HCC development in chronic HCV patients receiving direct-acting antiviral drugs. Further prospective studies with adequate long term follow up are needed to prove or disprove this relationship.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

Wahab¹,

Shehta

Ali³

2018

JST

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Hepatocellular Carcinoma with Gastrointestinal Involvement: A Systematic Review

et al. 2022

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In this paper, we aimed to evaluate clinical and imagistic features, and also to provide a diagnostic algorithm for patients presenting with gastrointestinal involvement from hepatocellular carcinoma (HCC). We conducted a systematic search on the PubMed, Scopus and Web of Science databases to identify and collect papers oncases of HCC with gastrointestinal involvement. This search was last updated on 29 April 2022. One hundred and twenty-three articles were included, corresponding to 197 patients. The majority of the patients were male (87.30%), with a mean age of 61.21 years old. The analysis showed large HCCs located mainly in the right hepatic lobe, and highly elevated alfa-fetoprotein (mean = 15,366.18 ng/mL). The most frequent etiological factor was hepatitis B virus (38.57%). Portal vein thrombosis was present in 27.91% of cases. HCC was previously treated in most cases by transarterial chemoembolization (32.99%) and surgical resection (28.93%). Gastrointestinal lesions, developed mainly through direct invasion and hematogenous routes, were predominantly detected in the stomach and duodenum in equal measure—27.91%. Gastrointestinal bleeding was the most common presentation (49.74%). The main diagnostic tools were esophagogastroduodenoscopy (EGD) and computed tomography. The mean survival time was 7.30 months. Gastrointestinal involvement in HCC should be included in the differential diagnosis of patients with underlying HCC and gastrointestinal manifestations or pathological findings in EGD.

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Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Cited by 2 publications

References 9 publications

Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

Hepatocellular Carcinoma with Gastrointestinal Involvement: A Systematic Review

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