Successful Emergent Lung Transplantation After Remote Ex Vivo Perfusion Optimization and Transportation of Donor Lungs

Wigfield, C.H.; Cypel, Marcelo; Yeung, Jonathan C.; Waddell, Tom; Alex, Charles G.; Johnson, Colin; Keshavjee, Shaf; Love, Robert B.

doi:10.1111/j.1600-6143.2012.04175.x

Cited by 50 publications

(27 citation statements)

References 16 publications

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“…In the future, we envision that retrieved lungs could be sent to organ evaluation and repair centers for final assessment and treatment for repair before distribution to recipients around the country. A case report describing the retrieval of injured lungs at one center, EVLP repair at a second center, and then transplantation at a third center across multiple political jurisdictions acts as a proof-of-concept for this approach (Wigfield et al 2012).…”

Section: Organ Preservationmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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Since the first successful lung transplant 30 years ago, lung transplantation has rapidly become an established standard of care to treat end-stage lung disease in selected patients. Advances in lung preservation, surgical technique, and immunosuppression regimens have resulted in the routine performance of lung transplantation around the world for an increasing number of patients, with wider indications. Despite this, donor shortages and chronic lung allograft dysfunction continue to prevent lung transplantation from reaching its full potential. With research into the underlying mechanisms of acute and chronic lung graft dysfunction and advances in personalized diagnostic and therapeutic approaches to both the donor lung and the lung transplant recipient, there is increasing confidence that we will improve short-and long-term outcomes in the near future.

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Section: Organ Preservationmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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“…With these and other advancements, vitreous cryopreservation now, for the first time, holds promise to be scalable to whole-organ cryobanking and to help transform transplantation in key ways [1-7, 13, 14, 19-22, 40-42, 156]. …”

Section: Bioengineering Applicationsmentioning

confidence: 99%

“…In addition to their role in helping to address organ shortage, advances in organ banking stand to greatly expand options for donor-recipient matching [1, 3, 6, 7] and equitable allocation; enhance screening for transmissible diseases and malignancies [1, 8-10]; decrease costs and enable flexible scheduling of surgeries [1, 14]; and allow assessment of organ quality before transplantation [3, 11-13]. Advanced organ preservation modalities could even provide the opportunity for cutting-edge pretransplant interventions with the potential to improve transplant outcomes, including immunomodulation [15, 16] or gene therapy [17] and other approaches for functional augmentation [3, 18] in specialized laboratories [1, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

New Approaches to Cryopreservation of Cells, Tissues, and Organs

Taylor¹,

Weegman²,

Baicu³

et al. 2019

Transfus Med Hemother

128

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In this concept article, we outline a variety of new approaches that have been conceived to address some of the remaining challenges for developing improved methods of biopreservation. This recognizes a true renaissance and variety of complimentary, high-potential approaches leveraging inspiration by nature, nanotechnology, the thermodynamics of pressure, and several other key fields. Development of an organ and tissue supply chain that can meet the healthcare demands of the 21st century means overcoming twin challenges of (1) having enough of these lifesaving resources and (2) having the means to store and transport them for a variety of applications. Each has distinct but overlapping logistical limitations affecting transplantation, regenerative medicine, and drug discovery, with challenges shared among major areas of biomedicine including tissue engineering, trauma care, transfusion medicine, and biomedical research. There are several approaches to biopreservation, the optimum choice of which is dictated by the nature and complexity of the tissue and the required length of storage. Short-term hypothermic storage at temperatures a few degrees above the freezing point has provided the basis for nearly all methods of preserving tissues and solid organs that, to date, have proved refractory to cryopreservation techniques successfully developed for single-cell systems. In essence, these short-term techniques have been based on designing solutions for cellular protection against the effects of warm and cold ischemia and basically rely upon the protective effects of reduced temperatures brought about by Arrhenius kinetics of chemical reactions. However, further optimization of such preservation strategies is now seen to be restricted. Long-term preservation calls for much lower temperatures and requires the tissue to withstand the rigors of heat and mass transfer during protocols designed to optimize cooling and warming in the presence of cryoprotective agents. It is now accepted that with current methods of cryopreservation, uncontrolled ice formation in structured tissues and organs at subzero temperatures is the single most critical factor that severely restricts the extent to which tissues can survive procedures involving freezing and thawing. In recent years, this major problem has been effectively circumvented in some tissues by using ice-free cryopreservation techniques based upon vitrification. Nevertheless, despite these promising advances there remain several recognized hurdles to be overcome before deep-subzero cryopreservation, either by classic freezing and thawing or by vitrification, can provide the much-needed means for biobanking complex tissues and organs for extended periods of weeks, months, or even years. In many cases, the approaches outlined here, including new underexplored paradigms of high-subzero preservation, are novel and inspired by mechanisms of freeze tolerance, or freeze avoidance, in nature. Others apply new bioengineering techniques such as nanotechnology, isochoric pressure preserv...

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“…The concept of specialized "organ repair centers", involving the use of remote EVLP, has emerged and could have significant implications for organ utilization and allocation in the future. (13) Finally, the development of ex vivo lung repair strategies for the broad spectrum of donor lung injury is a burgeoning and important area for research. Development of an ex vivo treatment arsenal, ranging in complexity from pharmacologic (antibiotics, thrombolytics, etc.)…”

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confidence: 99%

Uma nova era no transplante pulmonar: medicina personalizada a pulmões doados

Cypel

2012

J. bras. pneumol.

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Successful Emergent Lung Transplantation After Remote Ex Vivo Perfusion Optimization and Transportation of Donor Lungs

Cited by 50 publications

References 16 publications

Overview of Clinical Lung Transplantation

Overview of Clinical Lung Transplantation

New Approaches to Cryopreservation of Cells, Tissues, and Organs

Uma nova era no transplante pulmonar: medicina personalizada a pulmões doados

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