Successful doxycycline treatment of lymphatic fistulas: report of five cases and review of the literature

Hackert, Thilo; Werner, J. A.; Loos, Martin; Büchler, Markus W.; Weitz, Jürgen

doi:10.1007/s00423-006-0050-8

Cited by 26 publications

(16 citation statements)

References 16 publications

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“…They include drainage of the operative wound [6], external compression dressing [9], diathermy performed during surgery, ultrasound, argon, laser, harmonic scalpel [10], endoscopic procedures [11, 12], various techniques of axillary space closure [3, 13], fibrin glue [14–20], sclerotherapy using tetracyclines [21] and tranexamic acid application [7, 9]. However, no standard resulting in effective diminution of SF incidence following axillary dissection has yet been established.…”

Section: Introductionmentioning

confidence: 99%

Analysis of selected factors influencing seroma formation in breast cancer patients undergoing mastectomy

Zieliński¹,

Jaworski²,

Irga³

et al. 2013

aoms

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IntroductionThe aim of the work was to analyze the impact of selected factors on the incidence of seroma formation in breast cancer patients undergoing mastectomy.Material and methodsOne hundred and fifty breast cancer patients were prospectively enrolled in the study. All patients had mastectomy performed using the same operative technique with electrocoagulation. The amount of seroma formed after surgery and its duration were correlated with selected demographic, clinical and pathological parameters.ResultsThe cumulative total seroma volume collected by the end of treatment was higher and the overall time of seroma treatment was longer in patients over the age of 60 years (p = 0.001 and p = 0.001 respectively). Duration of seroma was significantly longer in obese patients (p = 0.036). The cumulative total seroma volume collected by the end of treatment was higher and the overall time of seroma treatment was longer in patients who had over 130 ml of lymph drained during the first 24 postoperative hours (p < 0.001 and p = 0.001 respectively). Additionally, longer duration of seroma was observed in patients with pathological stage I and II according to TNM-UICC (p = 0.042) and in patients with ≥ 1200 g weight resected of mammary gland (p = 0.05).ConclusionsAge and obesity are important prognostic factors influencing seroma formation in breast cancer patients undergoing mastectomy. The amount of lymph formed during first postoperative day may have predictive value in assessing cumulative total seroma volume collected during treatment and its overall duration.

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Section: Introductionmentioning

confidence: 99%

Analysis of selected factors influencing seroma formation in breast cancer patients undergoing mastectomy

Zieliński¹,

Jaworski²,

Irga³

et al. 2013

aoms

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“…Topical PA‐MSHA injection therapy in our study was successful to cease the leakage of chylous fluid, and completely cured the chyle fistula. Similar to other sclerosing agents such as tetracycline, doxycycline, and OK‐432 (sapylin), the mechanism of PA‐MSHA to treat chyle fistula is thought that it initiates a strong local inflammatory response, which results in fibrotic adhesion between tissue surfaces and spontaneous fistula closure. Chyle drainage in all patients showed a marked decrease within 24 to 48 hours after the use of PA‐MSHA.…”

Section: Discussionmentioning

confidence: 99%

Pseudomonas aeruginosa‐mannose sensitive hemagglutinin injection therapy for the treatment of chyle fistula following neck dissection

Chen

Zou

et al. 2019

Head & Neck

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Background The efficacy of Pseudomonas aeruginosa‐mannose sensitive hemagglutinin (PA‐MSHA) injection therapy in the treatment of chyle fistula following neck dissection is unclear. Methods This prospective study enrolled 26 patients who developed chyle fistula after neck dissection. Patients were divided into high‐output (>500 mL) and low‐output groups (≤500 mL) and were initially treated conservatively for 5 days in the high‐output group or 7 days in the low‐output group. When conservative treatment failed, topical PA‐MSHA therapy was applied. Results Twelve of 26 patients were cured with conservative treatment, and the remaining 14 patients were all successfully resolved by PA‐MSHA therapy. Chyle fistula got resolved in the low‐output and high‐output groups after the initiation of therapy were at a median 1 days and 6 days, respectively. Among them, 12 (85.7%) patients experienced fever and 11 (78.6%) patients experienced neck pain. Conclusions Topical PA‐MSHA injection therapy could effectively manage chyle fistula following neck dissection.

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“…Cnotliwy et al [13] reported a complete fistula closure following administration of doxycyclin in 11 patients (median 3 days). Hackert et al [14] confirmed the successful use of doxycyclin in 4 out of 5 patients with fistulas at various locations. In dehiscent wounds complicated by persisting lymphocutaneous fistulas, Greer et al [15] reported the successful use of vacuum-assisted wound closure (V.A.C) which is currently widely used in surgical and, in particular, chronic wounds.…”

mentioning

confidence: 89%

Etiology, Diagnosis and Treatment of Lymphocutaneous Fistulas, Chylascites and Chylothorax as Infrequent but Serious Complications Following Surgical Procedures*

Benedix

Lippert²,

Meyer³

2011

Zentralbl Chir

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Successful doxycycline treatment of lymphatic fistulas: report of five cases and review of the literature

Abstract: Doxycycline can be used for treatment of persistent postoperative lymphatic fistulas in different locations. In further studies, this therapeutic concept should be evaluated with larger numbers of patients with regard to the ideal point of time, frequency, and mode of application.

Cited by 26 publications

References 16 publications

Analysis of selected factors influencing seroma formation in breast cancer patients undergoing mastectomy

Analysis of selected factors influencing seroma formation in breast cancer patients undergoing mastectomy

Pseudomonas aeruginosa‐mannose sensitive hemagglutinin injection therapy for the treatment of chyle fistula following neck dissection

Etiology, Diagnosis and Treatment of Lymphocutaneous Fistulas, Chylascites and Chylothorax as Infrequent but Serious Complications Following Surgical Procedures*

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