Success rate and ART outcome of microsurgical sperm extraction in non obstructive azoospermia: A retrospective study

Vahidi, Serajoddin; Horoki, Ali Zare; Talkhooncheh, Mostafa Hashemi; Jambarsang, Sara; Marvast, Laleh Dehghan; Sadeghi, Ali Asghar; Eskandarian, Samane

doi:10.18502/ijrm.v19i9.9710

Cited by 8 publications

(8 citation statements)

References 37 publications

(38 reference statements)

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“…Therefore it could be believed that the NOA patients in the three groups could be compared. This result is consistent with Vahidi's study, except for the different fertilization rate (Vahidi et al, 2021). This suggested that the quality of embryos formed with sperm obtained by micro-TESE surgery from NOA patients of different causes is similar.…”

Section: Discussionsupporting

confidence: 92%

Micro-TESE surgery combined with ICSI regimen in the treatment of non-obstructive azoospermia patients and its effect analysis

Wang

Tang²,

Zhu³

et al. 2022

Zygote

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Summary This study aimed to analyze the clinical effects of microdissection testicular sperm extraction (micro-TESE) surgery combined with an intracytoplasmic sperm injection (ICSI) regimen in the treatment of non-obstructive azoospermia (NOA) patients with different etiologies. In total, 128 NOA patients participated in this study, in which they received infertility treatment by micro-TESE surgery combined with an ICSI regimen, and all patients were divided into three groups [the Klinefelter syndrome (KS), the idiopathic and the secondary NOA groups]. In addition, the sperm retrieval rate (SRR), fertilization rate, embryo development status and clinical treatment effects were analyzed. Among the 128 NOA patients, the SRR of KS NOA patients was 48.65%, those of idiopathic and the secondary patients were 33.82% and 73.91%, respectively. Regardless of etiologies, there was no correlation with age, hormone value or testicular volume. Further analysis showed that the SRR of the KS group was positively related with testosterone (T) values, and the SRR of the secondary group had a positive relationship with follicle-stimulating hormone or luteinizing hormone values. In the subsequent clinical treatment, the retrieved sperm was subjected to ICSI and achieved good treatment effects, especially in the secondary group, and the implantation rate (55.56%) and clinical pregnancy rate (68.42%) were both higher than those of the idiopathic group (28.75% and 40.00%) and KS group (22.05% and 30.77%). Micro-TESE surgery combined with ICSI insemination is the most effective treatment regimen for NOA patients. The SRR of NOA patients with different etiologies are related to certain specific factors, and micro-TESE surgery seems to be the ideal and only way to have biological children.

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Section: Discussionsupporting

confidence: 92%

Micro-TESE surgery combined with ICSI regimen in the treatment of non-obstructive azoospermia patients and its effect analysis

Wang

Tang²,

Zhu³

et al. 2022

Zygote

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“…This has been supported by a recent study as well (Pavan‐Jukic et al., 2020). On the other hand, many studies and meta‐analyses have shown that FSH and LH levels are a predictor of TESE success and as FSH and LH levels increase, the sperm retrieval rates decrease (Boitrelle et al., 2011; Liu et al., 2020; Majzoub et al., 2021; Vahidi et al., 2021; Yang et al., 2015). Also the data about serum testosterone levels in predicting TESE success are indecisive in the literature.…”

Section: Discussionmentioning

confidence: 99%

Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction

et al. 2022

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Infertility is a rising global health issue which has a deep impact on couples' psychosocial life and male factors cover about 50% of all infertility causes (Persily et al., 2021). Azoospermia, defined as the absence of spermatozoa in the ejaculate, is seen ~1% of all male population and this rate is increased up to 10% in men seeking solutions for infertility complaints (Kavoussi et al., 2020). Etiologically, azoospermia can be subdivided into two categories as obstructive and non-obstructive.

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“…12 Vahidi et al conducted research with 130 men who underwent Micro-TESE -ICSI cycle with results of successful fertilization, biochemical pregnancy, and live birth were seen in 111 (85,4%), 29 (22,3%), 29 (22,3%), and 14 men (10,75%), respectively. 13…”

Section: Discussionmentioning

confidence: 99%

Non-Obstructive Azoospermia with Hypergonadotropic Hypogonadism without a Significant Abnormalities in the Physical Examination

Ibrahim

Pakpahan

Narulita

2022

IABJ

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Background: Around 10 % of infertile men and 1 percent of all males have azoospermia. There are two types of azoospermia, which are obstructive and non-obstructive azoospermia. Non-obstructive azoospermia's main mechanism is because the testes fail to produce the sex hormone and induce spermatogenesis (primary testicular failure). Case: A patient is 28 years old and has a job as a car paint worker. He came with the chief complaint of infertility since two and a half years ago. He and his wife were having intercourse 3-4 times a week. Past medical history is unremarkable. His wife’s medical history is also unremarkable. Physical examination and ultrasound of the testes are normal. The semen analysis in this patient was azoospermia for 2 different times in the span of 2 weeks with no abnormalities in the accessory gland. Hormonal profiles results are testosterone level 2,32 ng/mL and FSH 15,03 mIU/mL, which indicatehypergonadotropic hypogonadism. The patient was suggested to evaluate further (complete hormonal profile, karyotyping analysis, and Y-Chromosome microdeletion) and educate about the possibility to conceive with assisted reproductive technology (ART). Discussion: Hypergonadotropic hypogonadism is a challenging case that needs a complete assessment such as complete hormonal profile, karyotyping analysis, Y-chromosome microdeletion analysis, and also, in this case, the paint thinner exposure in the workplace is needed to be considered. The chance of normal conception is very small, and the assisted reproductive procedure is necessary. Conclusion: Some abnormalities are usually present in the physical examination of azoospermia patients. This case convinces us of the importance of thorough history taking and other investigations. Managing this patient will be challenging, with the goal of the therapy is to achieve spermatogenesis to be able to use the spermatozoa available for ICSI.

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Success rate and ART outcome of microsurgical sperm extraction in non obstructive azoospermia: A retrospective study

Cited by 8 publications

References 37 publications

Micro-TESE surgery combined with ICSI regimen in the treatment of non-obstructive azoospermia patients and its effect analysis

Micro-TESE surgery combined with ICSI regimen in the treatment of non-obstructive azoospermia patients and its effect analysis

Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction

Non-Obstructive Azoospermia with Hypergonadotropic Hypogonadism without a Significant Abnormalities in the Physical Examination

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