Subwavelength light focusing using random nanoparticles

Park, Jung Hoon; Park, Chunghyun; Yu, Hyeonseung; Park, Jimin; Han, Seungyong; Shin, Jonghwa; Ko, Seung Hwan; Nam, Ki Tae; Cho, Yong-Hoon; Park, YongKeun

doi:10.1038/nphoton.2013.95

Cited by 172 publications

(140 citation statements)

References 30 publications

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“…We expect immediate and diverse applications of the present method including focusing and imaging inside biological tissues [25,[35][36][37], near-field control [38,39], nonlinear optics [40], optical fiber communications [41], stable laser resonators [42], and the delivery of high-power laser beams through a turbulent atmosphere [43]. In principle, the technique is also applicable for any form of waves including infrared, ultraviolet, seismic waves, and even x rays.…”

Section: Prl 115 153902 (2015) P H Y S I C a L R E V I E W L E T T Ementioning

confidence: 99%

One-Wave Optical Phase Conjugation Mirror by Actively Coupling Arbitrary Light Fields into a Single-Mode Reflector

Lee

Park

et al. 2015

Phys. Rev. Lett.

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Rewinding the arrow of time via phase conjugation is an intriguing phenomenon made possible by the wave property of light. Here, we demonstrate the realization of a one-wave optical phase conjugation mirror using a spatial light modulator. An adaptable single-mode filter is created, and a phase-conjugate beam is then prepared by reverse propagation through this filter. Our method is simple, alignment free, and fast while allowing high power throughput in the time-reversed wave, which has not been simultaneously demonstrated before. Using our method, we demonstrate high throughput full-field light delivery through highly scattering biological tissue and multimode fibers, even for quantum dot fluorescence.

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Section: Prl 115 153902 (2015) P H Y S I C a L R E V I E W L E T T Ementioning

confidence: 99%

One-Wave Optical Phase Conjugation Mirror by Actively Coupling Arbitrary Light Fields into a Single-Mode Reflector

Lee

Park

et al. 2015

Phys. Rev. Lett.

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“…However, a measurement of the high-resolution speckle pattern is required as a priori information. A high-NA scattering lens could only be used in above-mentioned method with a very challenging precalibration using NSOM [43]. In cases where a very high resolution speckle pattern is desired, a high-NA scattering lens is inevitable [16].…”

Section: Resultsmentioning

confidence: 99%

Speckle correlation resolution enhancement of wide-field fluorescence imaging

Yılmaz

Putten

Bertolotti

et al. 2015

Optica

117

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High-resolution fluorescence imaging is essential in nanoscience and biological sciences. Due to the diffraction limit, conventional imaging systems can only resolve structures larger than 200 nm. Here, we introduce a new fluorescence imaging method that enhances the resolution by using a high-index scattering medium as an imaging lens. Simultaneously, we achieve a wide field of view. We develop a new image reconstruction algorithm that converges even for complex object structures. We collect two-dimensional fluorescence images of a collection of 100 nm diameter dye-doped nanospheres, and demonstrate a deconvolved Abbe resolution of 116 nm with a field of view of 10 μm × 10 μm. Our method is robust against optical aberrations and stage drifts, and therefore is well suited to image nanostructures with high resolution under ambient conditions.

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“…To overcome the limitations of conventional AO, sophisticated wavefront control has recently emerged as a technique to compensate high-order wavefront distortions (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). This has been made possible by the development of wavefront modulators with a large number of pixels and can be considered as the extreme case of AO.…”

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confidence: 99%

High-resolution in vivo imaging of mouse brain through the intact skull

Park

Sun

Cui

2015

Proc. Natl. Acad. Sci. U.S.A.

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146

121

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Multiphoton microscopy is the current method of choice for in vivo deep-tissue imaging. The long laser wavelength suffers less scattering, and the 3D-confined excitation permits the use of scattered signal light. However, the imaging depth is still limited because of the complex refractive index distribution of biological tissue, which scrambles the incident light and destroys the optical focus needed for high resolution imaging. Here, we demonstrate a wavefrontshaping scheme that allows clear imaging through extremely turbid biological tissue, such as the skull, over an extended corrected field of view (FOV). The complex wavefront correction is obtained and directly conjugated to the turbid layer in a noninvasive manner. Using this technique, we demonstrate in vivo submicron-resolution imaging of neural dendrites and microglia dynamics through the intact skulls of adult mice. This is the first observation, to our knowledge, of dynamic morphological changes of microglia through the intact skull, allowing truly noninvasive studies of microglial immune activities free from external perturbations.neuroimaging | nonlinear microscopy | wavefront shaping | immunology | adaptive optics B reakthroughs in imaging technologies have been one of the major driving forces of new discoveries in biology (1). In the past two decades, we have witnessed that the advances of superresolution microscopy revolutionized our understanding of the complex dynamics in single cells (2). However, the techniques that work well on cultured cells often fail when being used to observe the cells in their native environment inside a living organism, the most ideal condition for biological studies. These difficulties result from the optical wavefront distortions induced by the inhomogeneous refractive index distribution in biological tissue.Because of this limitation, imaging inside deep tissue has been a challenging task, and the common goal of state of the art deep tissue-imaging methods is to recover the diffraction-limited resolution. These efforts can be categorized largely into two groups: the first capitalizes the use of longer wavelengths (3, 4) that undergo less scattering, whereas the second controls the optical wavefront, so that the wavefront distortions induced by the sample can be compensated (5-30). Longer wavelength excitation has demonstrated impressive penetration depths in the exposed brain (3) and imaging of the brain vascular structures beneath the skull (4). However, at the current state, using longer wavelengths is not a simple option because it requires special illumination sources [e.g., low repetition rate, high energy pulses (3)] or fluorescent probes (4), and provides only moderate spatial resolutions. In comparison, wavefront shaping allows the use of conventional light sources as well as the wide selection of wellestablished labels and functional indicators (31).Previous exciting works in adaptive optics (AO) have exploited these advantages and demonstrated aberration correction for a large field of view (FOV) by avera...

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Subwavelength light focusing using random nanoparticles

Cited by 172 publications

References 30 publications

One-Wave Optical Phase Conjugation Mirror by Actively Coupling Arbitrary Light Fields into a Single-Mode Reflector

One-Wave Optical Phase Conjugation Mirror by Actively Coupling Arbitrary Light Fields into a Single-Mode Reflector

Speckle correlation resolution enhancement of wide-field fluorescence imaging

High-resolution in vivo imaging of mouse brain through the intact skull

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