Subungual pleomorphic fibroma

Hsieh, Yu‐Ting; Lin, Yu–Chen; Wu, Yu‐Hung; Su, Hsin-Yi; Billings, Steven D.; Hood, Antoinette F.

doi:10.1034/j.1600-0560.2003.00105.x

Cited by 23 publications

(26 citation statements)

References 12 publications

(9 reference statements)

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“…Two cases included in this series, although having the characteristic feature of OM, had, in our opinion, degenerative changes similar to those seen in cutaneous tumors with ancient changes, such as ancient schwannoma or pleomorphic sclerotic fibroma. 17 The patient was advised to follow-up carefully. Two years later, there was no sign of recurrence or spreading of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Onychomatricoma: New Clinical and Histological Features. A Review of 19 Tumors

Perrin¹,

Baran²,

Balaguer³

et al. 2010

The American Journal of Dermatopathology

104

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To further define the clinicopathological spectrum of onychomatricoma (OM). We report the clinical feature, histological, and immunophenotypic characteristics of 19 cases of OM diagnosed between 2002 and 2007. The characteristic histologic appearance of OM is sometimes difficult to grasp because of 3 main factors: the anatomic particularities of the nail apparatus, the often fragmented aspect of the tissue specimen, and the choice of the section planes, which strongly modified the morphologic appearances observed. To prevent these difficulties, we built a tridimensional model using serial, transverse, and longitudinal sections. This reconstitution gives us a better understanding of the apparent diversity of the morphologic aspects observed in linking them to the anatomic site of the tumor. OM of the matrix is characterized by a thick nail plate with porch roof. OM of the ventral aspect of the proximal nail fold (PNF) is characterized by a nail plate without porch roof, exhibiting either a woodworm-like appearance or multiple cavities. In this second category, the fibrous base becomes elongated in shape, taking the shape of the anatomic contour of the PNF. The stroma gives rise to numerous fibroepithelial digitations. This pattern is different from the classical OM visualized in longitudinal sections, which appears as a single and large fibroepithelial tumor, that is, the multiple distal epithelial digitations arranged along a transversal plane are not seen. In the PNF variant, the characteristic clinical signs of OM fail to appear. We individualize 3 misleading clinical variants: tumor with a verrucous surface that is located in the lateral nail fold, as a band pattern suggesting wart or Bowen disease; a total dystrophy of the nail unit mimicking a squamous cell carcinoma; and pseudofibrokeratoma type. In the OM located on the ventral matrix, 3 new specific histologic variants were noted: pleomorphic OM, OM with a predominantly collagenous stroma, and superficial acral fibromyxoma-;like OM. OM is a benign tumor with a broader morphologic spectrum than previously thought. When the nail plate is not available, the immunohistochemistry can aid diagnosis by highlighting the peculiar immunophenotyping of OM, which expresses CD34 but not CD99, epithelial membrane antigen, S-100 protein, actin, and desmin.

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Section: Discussionmentioning

confidence: 99%

Onychomatricoma: New Clinical and Histological Features. A Review of 19 Tumors

Perrin¹,

Baran²,

Balaguer³

et al. 2010

The American Journal of Dermatopathology

104

View full text Add to dashboard Cite

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“…In addition to these mononuclear cells, the atypical nuclear features can also be observed in multinucleated giant cells. [13] Degeneration, ischemia, or the paracrine influence of mast cells may create the cytological atypia in PF. [145] Two variants have been described: Myxoid and sclerotic.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphology of pleomorphic fibroma of skin: A diagnostic enigma

Yadav

Kushwaha

Sharma

et al. 2013

J Cytol

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Pleomorphic fibroma (PF) is a benign, polypoid, or dome-shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells. We describe the cytomorphological features of PF retrospectively with histopathological diagnosis in a 38-year-old male who presented with 3 × 1.5 cm swelling in the soft tissues of the thigh for 6 months. This lesion is benign despite the presence of pleomorphic or bizarre cells. We review the differential diagnosis of PF with other mesenchymal tumors. To the best of our knowledge, cytomorphological features on fine needle aspiration cytology of this tumor are not yet documented in literature.

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“…32 To date, 2 cases of subungual pleomorphic fibromas have been reported. 32,33 Hsieh et al 32 reported a 66-year-old woman who presented with a 40-year history of a nail deformity of …”

Section: Pleomorphic Fibromamentioning

confidence: 98%

“…Pathology revealed a circumscribed, hypocellular tumor in the papillary and reticular dermis with scattered, hyperchromatic, spindled, pleomorphic, multinucleated giant cells within haphazard collagen bundles and a mild lymphohistiocytic perivascular infiltrate. Tumor cells stained positive for vimentin and negative for smooth muscle actin, cytokeratin, factor XIIIa, and CD34 32. …”

mentioning

confidence: 98%