Subtype-specific binding peptides enhance the therapeutic efficacy of nanomedicine in the treatment of ovarian cancer

Shen, Yao-An; Liu, Changsheng; Chang, Yen-Hou; Chen, Po-Hung; He, Chun-Lin; Wu, Han‐Chung; Chuang, Chi-Mu

doi:10.1016/j.canlet.2015.01.042

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…With longer incubation times (24 h), HUVECs could take up AuNPP-FA-Cy3 and AuNPP-Cy3 independent of tumor targeting (Supporting Information, Figure 6b); this might be a result of the nonselective endocytosis after a relatively long incubation. 22 However, their ability to take up AuNPP-FA-Cy3 remained much lower than that of 4T1 cells. The additional tumor targeting ability of AuNPP-FA-Cy3 led to an increase in fluorescence signal in 4T1 cells.…”

Section: Resultsmentioning

confidence: 93%

“…Accordingly, almost no uptake of AuNPP-FA-Cy3 was observed in HUVECs after incubation for 4 h (Figure c). With longer incubation times (24 h), HUVECs could take up AuNPP-FA-Cy3 and AuNPP-Cy3 independent of tumor targeting (Supporting Information, Figure 6b); this might be a result of the nonselective endocytosis after a relatively long incubation . However, their ability to take up AuNPP-FA-Cy3 remained much lower than that of 4T1 cells.…”

Section: Results and Discussionmentioning

confidence: 98%

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Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling

et al. 2020

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Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery properties and inherent anti-neoplastic activity. Here, we focused on the anti-neoplastic effects of an improved targeting polymer and folic acidmodified gold nanoparticles (AuNPP-FA) without therapeutic drugs. AuNPP-FA inhibited tumor proliferation both in vitro and in vivo, and tumor metastasis was controlled in vivo. We also found that, in addition to inhibiting tumor angiogenesis, AuNPP-FA normalized tumor vasculature by increasing pericyte coverage and strengthening tight junctions by upregulating VE-cadherin (VE-cad) levels on endothelial cells. This decreased vascular permeability, improved vascular perfusion, and alleviated tissue hypoxia. The immunotherapeutic response was enhanced due to the increased infiltration of CD3 + CD8 + T lymphocytes. AuNPP-FA increased the expression and secretion of semaphorin 3A (SEMA3A) in cancer cells to further inhibit Smad2/3 signaling in human umbilical vein endothelial cells (HUVECs). This normalized tumor vasculature and inhibited metastasis. In conclusion, AuNPP-FA normalized tumor vasculature; therefore, AuNPP-FA has great potential for future clinical applications.

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Section: Resultsmentioning

confidence: 93%

Section: Results and Discussionmentioning

confidence: 98%

Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling

et al. 2020

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“…Therefore, we utilized SKOV‐3 cells to develop a new therapeutic mAb for clear cell carcinoma. SKOV‐3 cells are a well characterized cell line that is frequently used for ovarian cancer antigen studies 42‐44 . We injected SKOV‐3 cells into the peritoneal cavity of BALB/cJ mice 3 times at 3‐wk intervals to serve as an immunogen for antibody production.…”

Section: Resultsmentioning

confidence: 99%

Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer

Chen

Lin

et al. 2020

Cancer Science

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“…Peptide-conjugated nanoparticles significantly improved tumor cell uptake and drug delivery internally, compared to non-targeted versions. Moreover, the targeted liposomal doxorubicin formulation achieved superior tumor suppression, indicating that phage display-derived subtype-specific therapies could offer more effective, targeted treatment options for varying epithelial ovarian cancer subtypes ( 98 ).…”

Section: Phage Display Applications In Ovarian Cancer Therapy and Dia...mentioning

confidence: 99%

Advancements in ovarian cancer immunodiagnostics and therapeutics via phage display technology

Li,

Yang

et al. 2024

Front. Immunol.

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Ovarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties in early detection are amplified by the limitations and inefficacies inherent in current screening methodologies, highlighting a pressing need for more efficacious diagnostic and treatment strategies. Phage display technology emerges as a pivotal innovation in this context, utilizing extensive phage-peptide libraries to identify ligands with specificity for cancer cell markers, thus enabling precision-targeted therapeutic strategies. This technology promises a paradigm shift in ovarian cancer management, concentrating on targeted drug delivery systems to improve treatment accuracy and efficacy while minimizing adverse effects. Through a meticulous review, this paper evaluates the revolutionary potential of phage display in enhancing ovarian cancer therapy, representing a significant advancement in combating this challenging disease. Phage display technology is heralded as an essential instrument for developing effective immunodiagnostic and therapeutic approaches in ovarian cancer, facilitating early detection, precision-targeted medication, and the implementation of customized treatment plans.

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Subtype-specific binding peptides enhance the therapeutic efficacy of nanomedicine in the treatment of ovarian cancer

Cited by 5 publications

References 40 publications

Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling

Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling

Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer

Advancements in ovarian cancer immunodiagnostics and therapeutics via phage display technology

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