Substrate-gate coupling in ZnO-FET biosensor for cardiac troponin I detection

Fathil, M. F. M.; Arshad, M. K. Md; Ruslinda, A. Rahim; Gopinath, Subash C. B.; M.N., M. Nuzaihan; Adzhri, R.; Hashim, U.; Lam, Hong Yoong

doi:10.1016/j.snb.2016.09.131

Cited by 68 publications

(36 citation statements)

References 37 publications

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“…-1 with limit of detection (LOD) of 3.24 pg/ml [22]. The specificity of the biosensor was also confirmed with 10 µg/ml of cTnT biomarker as non-specific protein (control), and 10 µg/ml of cTnI target biomarker.…”

Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 66%

“…Fathil et al [22] demonstrated various substrate-gate voltage (VSG) biases effect on the electron concentration of the ZnO-FET-based biosensor. Fig.…”

Section: Integration With Substrate-gate Biasingmentioning

confidence: 99%

“…BOX/Si substrate interface; (b) near the surface of the source, gate and drain region for different VSG bias [22].…”

Section: Fig 4 Electron Concentration On the Fet Biosensor At (A)mentioning

confidence: 99%

“…Fathil et al [22] demonstrated a FET-based biosensor's example for the detection of cTnI biomarker by using zinc oxide (ZnO)-FET biosensor. The device exhibited a significant decrease in measured ID as the concentrations of cTnI biomarker were increased from 1 ng/ml, 10 ng/ml, 100 ng/ml, 1 µg/ ml to 10 µg/ml as shown in Fig.…”

Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 99%

“…In comparison, a huge change in ID (~17%) was displayed by 10 µg/ml of cTnI biomarker compared to 10 µg/ml cTnT noncomplementary biomarker (~1%). Only cTnI biomarker, which exhibited a specific binding to the MAb-cTnI as bio-receptor allows the relative changes in measured ID [22].…”

Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 99%

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FET-biosensor for cardiac troponin biomarker

2017

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Abstract. Acute myocardial infarction or myocardial infarction (MI) is a major health problem, due to diminished flow of blood to the heart, leads to higher rates of mortality and morbidity. The most specific markers for cardiac injury are cardiac troponin I (cTnI) and cardiac troponin T (cTnT) which have been considered as 'gold standard'. Due to higher specificity, determination of the level of cardiac troponins became a predominant indicator for MI. Currently, field-effect transistor (FET)-based biosensors have been main interest to be implemented in portable sensors with the ultimate application in point-of-care testing (POCT). In this paper, we review on the FET-based biosensor based on its principle of operation, integration with nanomaterial, surface functionalization as well as immobilization, and the introduction of additional gate (for ambipolar conduction) on the device architecture for the detection of cardiac troponin I (cTnI) biomarker.

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Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 66%

“…Fathil et al [22] demonstrated various substrate-gate voltage (VSG) biases effect on the electron concentration of the ZnO-FET-based biosensor. Fig.…”

Section: Integration With Substrate-gate Biasingmentioning

confidence: 99%

“…BOX/Si substrate interface; (b) near the surface of the source, gate and drain region for different VSG bias [22].…”

Section: Fig 4 Electron Concentration On the Fet Biosensor At (A)mentioning

confidence: 99%

Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 99%

Section: Detection Of Ctni Cardiac Biomarkermentioning

confidence: 99%

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FET-biosensor for cardiac troponin biomarker

2017

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Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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Electrochemical detection of the cardiac biomarker cardiac troponin I

Qin,

Li,

Qin

et al. 2024

VIEW

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Acute myocardial infarction (AMI) is a major cause of cardiovascular disease‐related death. It is essential for patients with cardiovascular disease to receive an early diagnosis of AMI. The most popular technique for the early detection of AMI is the use of biosensors to monitor the concentration of pertinent biomarkers, such as cardiac troponin I (cTnI), in the blood. The electrochemical detection methods hold great promise because of their simplicity, miniaturization, ease of integration, high sensitivity, and rapid response. The prime motive of this review is to present a comprehensive understanding of the pros and cons of methodologies employed for the electrochemical approaches toward the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on various affinity elements. We enumerate the modified electrode materials for electrochemical sensors as well as popular detection techniques. Furthermore, this paper reviews some recent significant advances in point‐of‐care assays for rapid, accurate detection of cTnI as a smart integrated device for home monitoring. The accumulation of knowledge about these functions will lead to new insights into and concepts for the design of portable miniature sensors for cardiovascular patients at risk of AMI. It is anticipated that the interdisciplinary collaboration can bring more enlightenment to the progress of cardiac biomarkers sensor in the future.

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Substrate-gate coupling in ZnO-FET biosensor for cardiac troponin I detection

Cited by 68 publications

References 37 publications

FET-biosensor for cardiac troponin biomarker

FET-biosensor for cardiac troponin biomarker

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Electrochemical detection of the cardiac biomarker cardiac troponin I

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