Substituted imino and amino derivatives of 4-hydroxycoumarins as novel antioxidant, antibacterial and antifungal agents: Synthesis and in vitro assessments

Choline Hydroxide: An Efficient and Biocompatible Basic Catalyst for the Synthesis of Biscoumarins Under Mild Conditions

“…Biscoumarin and its derivatives have received increasing attention due to their wide range of biological activity such as anti-HIV, anti-bacterial, anti-oxidant, anti-cancer, and anti-coagulant activities [1][2][3][4]. Biscoumarins are usually synthesized through the Domino Knoevenagel-Michael reactions of aldehydes with two equivalents of 4-hydroxycoumarin in the presence of catalyst.…”

Crystal structure of 3-amino-8-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C21H16N2O2

“…In recent years, they have attracted considerable attention due to their antimicrobial [2,3], antileishmanial [4][5][6][7][8][9], anticancer [10][11][12][13][14][15], antiproliferative [22], antioxidant [16][17][18], hypertensive [14], antitumor [19][20][21] effects and activities, as well as proving potentially useful in the treatment of Alzheimer's disease [23] and schizophrenia disorder [24].…”

Crystal structure of 3-amino-9-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C21H16N2O2

“…Chromene and benzochromene derivatives have attracted considerable interest owing to their biological and pharmaceutical activities such as antibacterial [1][2][3], antifungal [4][5][6], vascular-disrupting [7], antioxidant [8,9], anticancer [10][11][12][13], estrogenic anticoagulant and antispasmolytic [14], antileishmanial [15], antiproliferative and apoptosis inducing [16][17][18][19].…”