A variety of novel [1,2,4]triazolo[1,5-c]pyrimidine-13-ones (4a-f) and (5b-d) could be obtained via reaction of 9-amino-7-(4’-chlorophenyl)-8,9-dihydro-8-imino-6H,7H-[1]benzopyrano[3`,4`:5,6]pyrano[2,3-d]pyrimidine-6-one (3) with a variety of reagents. Pyrano[2,3-d]pyrimidine-6-ones 5a, 8a-c and pyrimido[1,6-b][1,2,4]-triazine-3,14-dione (6) were also prepared. The antimicrobial activity of some of the synthesized compounds was tested.
Activities. -A variety of novel fused benzochromene derivatives are synthesized using readily available chromenecarbonitriles (IIId-f) as the key intermediates. The majority of the compounds synthesized show antimicrobial activity. -(KHAFAGY, M. M.; ABD EL-WAHAB, A. H. F.; EID, F. A.; EL-AGRODY*, A. M.; Farmaco 57 (2002) 9, 715-722; Dep. Chem., Fac. Sci., Al-Azhar Univ., Nasr City, Cairo 11884, Egypt; Eng.) -R. Langenstrassen 04-130
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