Substituted coumarins as potent 5-lipoxygenase inhibitors

Grimm, Erich L.; Brideau, Christine; Chauret, Nathalie; Chen, Chan; Delorme, Daniel; Ducharme, Yves; Ethier, Diane; Falgueyret, Jean‐Pierre; Friesen, Richard W.; Guay, Jocelyne; Hamel, P.; Riendeau, Denis; Soucy-Breau, Chantal; Tagari, Philip; Girard, Yves

doi:10.1016/j.bmcl.2006.01.085

Cited by 48 publications

(16 citation statements)

References 28 publications

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“…The Schiff base ligands of coumarine and their metal complexes found paramount applications, they are well-known as antioxidants [2], pharmaceutical agents [3] and as luminescent materials [4]. They have pronounced medicinal value as anticoagulants [5], free radical scavengers [6] and as lipoxygenase [7] and cyclooxygenase inhibitors [8]. Moreover, many coumarin derivatives exhibit high antibacterial [9], antifungal [10] and cytotoxic activities [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Mahmoud

Linert

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Mahmoud

Linert

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Monitoring of the reaction progress and product purification was carried out by TLC. (15). Yield 60% (1.02 mmol, 375.3 mg); pale yellow oil; IR (cm (22).…”

Section: General Procedures For the Synthesis Of Bromoalkyl Derivativesmentioning

confidence: 99%

“…Coumarins and chromones are important classes of compounds having versatile biological activities [14][15][16][17][18][19][20][21][22]. Both moieties are well known for their antiprotozoal activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

et al. 2014

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Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes. Cytotoxic activity was also evaluated against mammalian U-937 cells. Compounds 7-9 and 17, were active against Leishmania parasites (EC 50 = 9.4; 10.2; 13.5 and 27.5 µg/mL, respectively) and showed no toxicity toward mammalian cells (>200 µg/mL). They are potential candidates for antileishmanial drug development. Compounds 25-27, were active and cytotoxic. Further studies using OPEN ACCESSMolecules 2014, 19 13252 other cell types are needed in order to discriminate whether the toxicity shown by these compounds is against tumor or non-tumor cells. The results indicate that compounds containing small alkyl chains show better selectivity indices. Moreover, Michael acceptor moieties may modify both the leishmanicidal activity and cytotoxicity. Further studies are required to evaluate if the in vitro activity against Leishmania panamensis demonstrated here is also observed in vivo.

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“…1,2,4-Oxadiazole derivatives have been reported as potent anti-inflammatory agents with selectivity for COX-2 [32][33][34] . 3-Phenyl-1,2,4-oxadiazole derivative has been reported to exhibit analgesic activity far superior than aspirin 35 . Compounds containing coumarin moiety have also been reported to possess wide spectrum of biological activity like anti-inflammatory, anticancer, antirheumatic, and so on.…”

Section: Research Articlementioning

confidence: 99%

Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity

Akhter

Alam

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Substituted coumarins as potent 5-lipoxygenase inhibitors

Cited by 48 publications

References 28 publications

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity

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