Substituted Amides of Quinoline Derivatives: Preparation and Their Photosynthesis-inhibiting Activity

Abstract

The series of nine amides of substituted 8-hydroxyquinolines were prepared. The synthetic procedures of compounds are presented. All the prepared quinoline derivatives were analyzed using RP-HPLC method for the lipophilicity measurement and their lipophilicity were determined. The prepared compounds were tested for the reduction of chlorophyll content in Chlorella vulgaris Beij. Several compounds showed biological activity comparable with or higher than the standard 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well as structure-activity relationships (SAR) between the chemical structure and the biological activities of the evaluated compounds.

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Their Photosynthesis-inhibiting Activity

“…Our study dealing with 8-hydroxyquinoline and styrylquinoline derivatives showed that they could possess also strong antifungal activity [11][12][13]. According to the results reported recently some new hydroxyquinoline derivatives possess interesting herbicidal activities as well [12,[14][15][16][17][18]. Some investigated compounds showed also antineoplastic activity [19].…”

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity

“…Our previous study dealing with 8-hydroxyquinoline and styrylquinoline derivatives showed that they could also possess a strong antifungal activity [ 5 , 6 , 7 ]. According to the results reported recently, some new hydroxyquinoline derivatives also possess interesting herbicidal activities [ 6 , 8 , 9 , 10 , 11 , 12 , 13 ]. Some investigated compounds also showed antineoplastic activity [ 14 ].…”