Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Their Photosynthesis-inhibiting Activity

Abstract

The series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The synthetic procedures of the compounds are presented. All the prepared quinoline derivatives were analyzed using RP-HPLC method for the lipophilicity measurement and their lipophilicity was determined. The prepared compounds were tested for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.). The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well as the structure-activity relationships (SAR) between the chemical structure and the biological activities of the evaluated compounds.

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity

“…Our previous study dealing with 8-hydroxyquinoline and styrylquinoline derivatives showed that they could also possess a strong antifungal activity [ 5 , 6 , 7 ]. According to the results reported recently, some new hydroxyquinoline derivatives also possess interesting herbicidal activities [ 6 , 8 , 9 , 10 , 11 , 12 , 13 ]. Some investigated compounds also showed antineoplastic activity [ 14 ].…”