Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus

Sastry, B.R.; Chirwa, S.S.; May, P. B. Y.; Maretić, H.

doi:10.1016/0304-3940(88)90256-x

Cited by 20 publications

(1 citation statement)

References 8 publications

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“…This increase in synaptic strength lasts for many hours and, in the intact animals, even for weeks (Bliss and Lorno, 1973;Bliss and Gardner-Medwin, 1973). It has been suggested that neurite-inducing factors are released during tetanic stimulation and that these substances are involved in LTP (Sastry et a / . , 1988).…”

Section: Introductionmentioning

confidence: 99%

Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice

Terlau

Seifert

1990

Eur J of Neuroscience

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Recently we reported that perfusion of hippocampal slices with epidermal growth factor (EGF) lead to enhancement of potentiated responses after tetanic stimulation. In the present study we report that basic fibroblast growth factor (FGF) can also lead to an enhancement of potentiated responses. FGF is a mitogen for several cell types and exhibits neurotrophic effects on neurons of the central nervous system (CNS). Rat hippocampal slices were perfused with FGF at a concentration of 10-9 M. During extra- and intracellular recordings in the CA1-region, the addition of FGF to the perfusing medium produced no change in evoked responses if single pulse or paired pulse stimulation was used. Furthermore FGF had no influence on the resting membrane potential and input resistance. However, after tetanic stimulation, FGF-treated slices showed an increase in the magnitude of potentiation compared to control slices. Taken together with the EGF data these results support the hypothesis that growth factors like FGF with neurotrophic potential on CNS-neurons can influence synaptic efficacy. Furthermore these results show that factors which are able to modulate developmental plasticity and regenerative plasticity can also modulate synaptic plasticity.

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Section: Introductionmentioning

confidence: 99%

Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice

Terlau

Seifert

1990

Eur J of Neuroscience

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Modulation of the Induction of Long-Term Potentiation in the Hippocampus

Sastry

Maretić

Morishita

et al. 1990

Excitatory Amino Acids and Neuronal Plasticity

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Influence of perfusates of tetanized donor slices on the induction of long-term potentiation in recipient slices

Mokrushin

Karpova²

1995

Neurosci Behav Physiol

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A perfusate collected from donor slices of the olfactory cortex of the brain of rats during tetanization of the lateral olfactory tract (100 imp/sec, 30 sec) induced prolonged changes in the amplitudes of various components of the focal potentials (FP) in recipient slices. When the perfusates are divided in relation to the reactions arising in the donor slices into three types, "potentiated," "depressive," and "nonpotentiated," the reactions of the recipient slices prove to be diverse. The potentiated perfusate induced the development of depression. The depressive induced potentiation. The reactions of the recipient slices to the nonpotentiated perfusate were indeterminate. The data obtained suggest the secretion of active substances during the electrical tetanization of donor slices. These factors are capable of inducing reactions in the recipient slices which the donor slices had "experienced."

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Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus

Cited by 20 publications

References 8 publications

Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice

Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice

Modulation of the Induction of Long-Term Potentiation in the Hippocampus

Influence of perfusates of tetanized donor slices on the induction of long-term potentiation in recipient slices

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