Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption

Yamaguchi, Masaru; Ozawa, Yuichiro; Mishima, Hiroyuki; Aihara, Norihito; Kojima, Tadashi; Kasai, Kazuhiko

doi:10.1016/j.ajodo.2006.03.043

Cited by 28 publications

(21 citation statements)

References 42 publications

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“…BMSC treated with NGF or BDNF without inhibitors had a significant increase in IL-6 protein (p = .001 and p = .002 respectively as determined by a Student's t-test (#)). doi:10.1371/journal.pone.0009690.g007 inflammatory cytokines in fibroblastic cells [63,64] and more recently in a model of increased IL-6, IL-1b, and TNF-a in a model of burn-induced lung injury [65]. These reports raise the possibility that Substance-P may be an intermediate between neurotrophic factor exposure and altered gene expression in BMSC as well which has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway.

Rezaee¹,

Rellick²,

Akers³

et al. 2009

B33. Immunology/Inflammation

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Background: The host's response to infection is characterized by altered levels of neurotrophins and an influx of inflammatory cells to sites of injured tissue. Progenitor cells that give rise to the differentiated cellular mediators of inflammation are derived from bone marrow progenitor cells where their development is regulated, in part, by cues from bone marrow stromal cells (BMSC). As such, alteration of BMSC function in response to elevated systemic mediators has the potential to alter their function in biologically relevant ways, including downstream alteration of cytokine production that influences hematopoietic development.

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Section: Discussionmentioning

confidence: 99%

Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway.

Rezaee¹,

Rellick²,

Akers³

et al. 2009

B33. Immunology/Inflammation

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“…[15][16][17][18][19][20][21] Mechanical stimuli also trigger molecular changes in GCF, but it is not clear whether these changes are linked to those in the PDL. 1,5,6,21 In this study, the entire PDL was collected for molecular analysis for 2 major reasons: (1) because GCF continuously circulates in the PDL, there is no clear-cut difference in the assessment of cytokines in GCF from the pressure or tension areas 21 ; and (2) regardless of the type of tooth movement, 22-25 irregular patterns of stress occur because of uneven strain distribution in the PDL, making it difficult to precisely define the sites of tension and pressure.…”

Section: Discussionmentioning

confidence: 97%

Cytokine measurements in gingival crevicular fluid and periodontal ligament: Are they correlated?

Madureira

Silva

Teixeira

et al. 2015

American Journal of Orthodontics and Dentofacial Orthopedics

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“…This, in turn, prompts arrival of different neurotransmitters bringing about renovation and adjustment of the natural framework to the more up-todate condition. 13,14 Due to this rule, renovating of the periodontal tendon and the alveolar bone around a tooth happens amid orthodontic drive application. Research is continually being done and refreshed consistently on the science of orthodontic tooth development and the tissue-level reaction inside the cell level on utilization of orthodontic constraint.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Myeloperoxidase Enzymatic Activity in Gingival Crevicular Fluid of Subjects having Orthodontic Treatment by Different Aligning Arch Wires

Bhasin¹,

Singh²,

Goutam³

et al. 2017

The Journal of Contemporary Dental Practice

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Introduction: There exist a number of factors that affect the outcome of orthodontic treatment. These factors can be assessed by various gingival markers. One such maker is myeloperoxidase (MPO). Hence, we planned the present study to assess and compare the MPO activity in the gingival crevicular fluid (GCF) of subjects undergoing orthodontic treatment by different aligning arch wires. Materials and methods:The present study included assessment of patients who underwent orthodontic treatment for crowding of anterior teeth. Diagnostic cast models of all the subjects were made for recording the irregularity index. All the subjects were randomly divided into three study groups with 15 patients in each group based on the type of nickel-titanium (NiTi) arch wires used. A collection of GCF samples was done in all the patients at various time intervals and it was sent to the laboratory for assessment of MPO activity. Activity of the MPO enzyme was expressed in terms of number of units per 100 µL. All the results obtained were compiled and analyzed by Statistical Package for the Social Sciences (SPSS) software. Results Conclusion:Both superelastic NiTi and heat-activated NiTi generate optimal forces, which are necessary for higher metabolic response of the periodontal ligament. Clinical significance:In the intimal stages of orthodontic treatment, both superelastic NiTi and heat-activated NiTi wires are superior in leveling and aligning the crowded teeth.

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Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption

Cited by 28 publications

References 42 publications

Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway.

Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway.

Cytokine measurements in gingival crevicular fluid and periodontal ligament: Are they correlated?

Comparative Evaluation of Myeloperoxidase Enzymatic Activity in Gingival Crevicular Fluid of Subjects having Orthodontic Treatment by Different Aligning Arch Wires

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