Substance P in keratosis follicularis spinulosa decalvans

Doche, Isabella; Hordinsky, Maria; Wilcox, George L.; Valente, Neusa Yuriko Sakai; Romiti, Ricardo

doi:10.1016/j.jdcr.2015.08.001

Cited by 3 publications

(1 citation statement)

References 7 publications

(9 reference statements)

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“…Furthermore, KFSD has been described in association with various conditions, including cutis laxa, “big pinnae,” clinodactyly, arachnodactyly, Noonan’s syndrome, Down’s syndrome, hepatomegaly, and bilateral inguinal hernia [17, 22, 23]; a greater propensity to recurrent systemic bacterial infections has also been reported [18]. Severe pruritus could be present, and it could be related to increased levels of substance P, which have been reported in many inflammatory skin conditions, including alopecia areata, atopic dermatitis, and psoriasis [24].…”

Section: Discussionmentioning

confidence: 99%

The Role of Trichoscopy in Keratosis Follicularis Spinulosa Decalvans: Case Report and Review of the Literature

Alessandrini¹,

Brattoli²,

Piraccini³

et al. 2020

Skin Appendage Disord

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Introduction: Keratosis follicularis spinulosa decalvans (KFSD) is a rare, X-linked, hereditary disorder of keratinization, characterized by skin involvement and progressive scarring alopecia of scalp, eyebrows, and eyelashes. The diagnosis is helped by the particular clinical features, but pathology is mandatory. Case Presentation: We described a case of a female patient referred to the outpatient’s hair consultation of our department, in which we performed trichoscopy as a very useful tool for the diagnosis, followed by pathology that confirmed KFSD. Conclusion: In our article, we underlined the importance of trichoscopy for the diagnosis of this hair disease, with also a review of the literature on diagnosis and treatment.

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