Substance-P blocks degeneration of retina by stimulating migration and proliferation of retinal pigmented epithelial cells

Hong, Hoon Pyo; Kim, Suna; Kim, Yeong Hoon; Park, Ju Hyeong; Jin, Yinji; Son, Youngsook

doi:10.1007/s13770-014-0088-6

Cited by 8 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, substance P could induce inflammatory response via evoking activation of the NF-κB signaling pathway ( 37 ). On the other hand, substance P promotes proliferation and mobilizes stem cells to the site of injury, leading to facilitation of mucosal healing in colitis ( 38 ). Hong et al ( 39 ) also reported that dextran sulfate sodium-induced intestinal damage was effectively ameliorated by substance P via enrichment of M2 macrophages and regulatory T cells.…”

Section: Discussionmentioning

confidence: 99%

TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal

Yong

Yuan

Cao

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

Ulcerative colitis is a chronic inflammatory disease of the colon where intestinal motility is disturbed. Interstitial cells of Cajal (ICC) are required to maintain normal intestinal motility. In the present study, we assessed the effect of tumor necrosis factor-alpha (TNF-α) on viability and apoptosis of ICC, as well as on the expression of stem cell factor (SCF), ghrelin, and substance P. ICC were derived from the small intestines of Swiss albino mice. Cell viability and apoptosis were measured using CCK-8 assay and flow cytometry, respectively. ELISA was used to measure the concentrations of IL-1β, IL-6, ghrelin, substance P, and endothelin-1. Quantitative RT-PCR was used to measure the expression of SCF. Western blotting was used to measure the expression of apoptosis-related proteins, interleukins, SCF, and NF-κB signaling pathway proteins. TNF-α induced inflammatory injury in ICC by decreasing cell viability and increasing apoptosis and levels of IL-1β and IL-6. TNF-α decreased the levels of SCF, ghrelin, and substance P, but had no effect on endothelin-1. TNF-α down-regulated expressions of SCF, ghrelin, and substance P by activating the NF-κB pathway in ICC. In conclusion, TNF-α down-regulated the expressions of SCF, ghrelin, and substance P via the activation of the NF-κB pathway in ICC.

show abstract

Section: Discussionmentioning

confidence: 99%

TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal

Yong

Yuan

Cao

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…The processing parameters of PCL fibers have been optimized to fabricate macroporous and microfibrous grafts to facilitate cellularization and remodeling, which has been documented by us before. 28 Our group has also previously optimized the electrospinning conditions to fabricate collagen fibers (data not shown), which were used to encapsulate SP and SDF-1α–derived peptides in this study. We envision that collagen nanofibers will degrade in vivo resulting in the release of SP and SDF-1α peptides, which can enhance endogenous stem and progenitor cell mobilization and recruitment.…”

Section: Resultsmentioning

confidence: 99%

“… 24 – 26 Moreover, SP has been shown to enhance the neovascularization, modulate the host’s inflammatory response, and stimulate the production of a variety of cytokines and growth factors. 27 , 28 We and others have previously documented that SP promotes tissue repair in various injury models. 20 , 25 , 26 In view of the multifunctional nature of both angiogenic and chemotactic activities, the use of SP seems of great potential for TE.…”

mentioning

confidence: 93%

In Situ Blood Vessel Regeneration Using SP (Substance P) and SDF (Stromal Cell–Derived Factor)-1α Peptide Eluting Vascular Grafts

Shafiq

Zhang

Zhi

et al. 2018

ATVB

View full text Add to dashboard Cite

show abstract

“…Exogenous SP accelerated wound closure in fullthickness excisional wound healing model of non-diabetic and diabetic mice and the wound healing was delayed NK1R knockout mice (33,34). Proliferation and cell viability of retinal pigment epithelium (RPE) cells were enhanced by SP (35). SP also promoted RPE migration to prevent retinal degeneration in ARPE-19 cell and laser-induced retinal degeneration model (35).…”

Section: Discussionmentioning

confidence: 99%

“…Proliferation and cell viability of retinal pigment epithelium (RPE) cells were enhanced by SP (35). SP also promoted RPE migration to prevent retinal degeneration in ARPE-19 cell and laser-induced retinal degeneration model (35). The generation of ROS and mitochondrial dysfunction under the diabetic environment were weakened by SP and it caused the epithelial wound healing (36).…”

Section: Discussionmentioning

confidence: 99%

Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response

et al. 2020

Self Cite

View full text Add to dashboard Cite

Substance P (SP), an injury-inducible messenger that mobilizes bone marrow stem cells and modulates the immune response, has been suggested as a novel target for therapeutic agents. We evaluated the role of SP as an immune cell modulator during the progression of renal ischemic/reperfusion injury (IRI). Unilateral IRI induced the transient expression of endogenous SP and the infiltration of CCR7 + M1 macrophages in injured kidneys. However, SP altered the intrarenal macrophage polarization from CCR7 + M1 macrophages to CD206 + M2 macrophages in injured kidneys. SP also modulated bone marrow-derived neutrophils and mesenchymal stromal cells after IRI. SP treatment for 4 weeks starting one week after unilateral IRI significantly preserved kidney size and length and normal tubular structures and alleviated necrotic tubules, inflammation, apoptosis, and tubulointerstitial fibrosis. The beneficial effects of SP were accompanied by attenuation of intrarenal recruitment of CD4, CD8, and CD20 cells and abnormal angiogenesis. The immunomodulatory effect of SP suggested that SP could be a promising therapeutic target for preventing the progression of acute kidney injury to chronic kidney disease.

show abstract

Substance-P blocks degeneration of retina by stimulating migration and proliferation of retinal pigmented epithelial cells

Cited by 8 publications

References 16 publications

TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal

TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal

In Situ Blood Vessel Regeneration Using SP (Substance P) and SDF (Stromal Cell–Derived Factor)-1α Peptide Eluting Vascular Grafts

Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response

Contact Info

Product

Resources

About